Aggregation-disaggregation transition of DNA-coated colloids: Experiments and theory

Rémi Dreyfus, Mirjam E. Leunissen, Roujie Sha, Alexei Tkachenko, Nadrian C. Seeman, David J. Pine, Paul M. Chaikin

Research output: Contribution to journalArticle

Abstract

Colloids coated with complementary single-stranded DNA "sticky ends" associate and dissociate upon heating. Recently, microscopy experiments have been carried out where this association-dissociation transition has been investigated for different types of DNA and different DNA coverages. It has been shown that this transition can be described by a simple quantitative model which takes into account the features of the tethered DNA on the particles and unravels the importance of an entropy cost due to DNA confinement between the surfaces. In this paper, we first present an extensive description of the experiments that were carried out. A step-by-step model is then developed starting from the level of statistical mechanics of tethered DNA to that of colloidal aggregates. This model is shown to describe the experiments with excellent agreement for the temperature and width of the transition, which are both essential properties for complex self-assembly processes.

Original languageEnglish (US)
Article number041404
JournalPhysical Review E
Volume81
Issue number4
DOIs
StatePublished - Apr 23 2010

Fingerprint

Disaggregation
Colloids
colloids
Aggregation
deoxyribonucleic acid
Experiment
Self-assembly
Statistical Mechanics
Microscopy
Heating
Coverage
Entropy
Model
Costs
statistical mechanics
self assembly
dissociation
entropy
microscopy
costs

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Statistical and Nonlinear Physics
  • Statistics and Probability

Cite this

Aggregation-disaggregation transition of DNA-coated colloids : Experiments and theory. / Dreyfus, Rémi; Leunissen, Mirjam E.; Sha, Roujie; Tkachenko, Alexei; Seeman, Nadrian C.; Pine, David J.; Chaikin, Paul M.

In: Physical Review E, Vol. 81, No. 4, 041404, 23.04.2010.

Research output: Contribution to journalArticle

Dreyfus, Rémi ; Leunissen, Mirjam E. ; Sha, Roujie ; Tkachenko, Alexei ; Seeman, Nadrian C. ; Pine, David J. ; Chaikin, Paul M. / Aggregation-disaggregation transition of DNA-coated colloids : Experiments and theory. In: Physical Review E. 2010 ; Vol. 81, No. 4.
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