Age-Dependent Prognostic Effects of Genetic Alterations in Glioblastoma

Tracy T. Batchelor, Rebecca Betensky, J. Matthew Esposito, Loc Duyen D. Pham, Molly V. Dorfman, Nicole Piscatelli, Sarah Jhung, David Rhee, David N. Louis

Research output: Contribution to journalArticle

Abstract

Purpose: Although the genetic alterations in glioblastoma have been well characterized, reports regarding their prognostic effects have been inconsistent. Experimental Design: In this series of 140 consecutive cases of glioblastoma treated at a single center, we analyzed the frequency, age dependency and prognostic effects of TP53 mutation, CDKN2A/p16 deletion, EGFR amplification, as well as loss of chromosome 1p, chromosome 10q, and chromosome 19q. The complete set of genetic alterations was available on 60 of 140 patients. Results: In this cohort of glioblastoma cases, TP53 mutation was significantly associated with patient age. The prognostic effects of TP53 mutation, EGFR amplification, CDKN2A/p16 alterations, and loss of chromosome 1p were dependent on the age of the patient. Conclusions: This is the first observation that the prognostic effects of TP53, 1p, and CDKN2A/p16 alterations are dependent on patient age. These observations concerning the interactions of age and genetic changes in glioblastoma suggest that tumorigenic pathways to glioblastoma vary with the age of the patient and that future molecular marker studies should carefully evaluate the potential age-dependent prognostic effects of these biological variables. The inconsistent or negative prognostic effects of molecular markers reported in prior studies of glioblastoma may be because different effects at different ages may have resulted in a cancellation of an overall effect in the entire cohort.

Original languageEnglish (US)
Pages (from-to)228-233
Number of pages6
JournalClinical Cancer Research
Volume10
Issue number1 I
DOIs
StatePublished - Jan 1 2004

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Glioblastoma
Chromosomes
Mutation
Research Design
Observation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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Batchelor, T. T., Betensky, R., Esposito, J. M., Pham, L. D. D., Dorfman, M. V., Piscatelli, N., ... Louis, D. N. (2004). Age-Dependent Prognostic Effects of Genetic Alterations in Glioblastoma. Clinical Cancer Research, 10(1 I), 228-233. https://doi.org/10.1158/1078-0432.CCR-0841-3

Age-Dependent Prognostic Effects of Genetic Alterations in Glioblastoma. / Batchelor, Tracy T.; Betensky, Rebecca; Esposito, J. Matthew; Pham, Loc Duyen D.; Dorfman, Molly V.; Piscatelli, Nicole; Jhung, Sarah; Rhee, David; Louis, David N.

In: Clinical Cancer Research, Vol. 10, No. 1 I, 01.01.2004, p. 228-233.

Research output: Contribution to journalArticle

Batchelor, TT, Betensky, R, Esposito, JM, Pham, LDD, Dorfman, MV, Piscatelli, N, Jhung, S, Rhee, D & Louis, DN 2004, 'Age-Dependent Prognostic Effects of Genetic Alterations in Glioblastoma', Clinical Cancer Research, vol. 10, no. 1 I, pp. 228-233. https://doi.org/10.1158/1078-0432.CCR-0841-3
Batchelor TT, Betensky R, Esposito JM, Pham LDD, Dorfman MV, Piscatelli N et al. Age-Dependent Prognostic Effects of Genetic Alterations in Glioblastoma. Clinical Cancer Research. 2004 Jan 1;10(1 I):228-233. https://doi.org/10.1158/1078-0432.CCR-0841-3
Batchelor, Tracy T. ; Betensky, Rebecca ; Esposito, J. Matthew ; Pham, Loc Duyen D. ; Dorfman, Molly V. ; Piscatelli, Nicole ; Jhung, Sarah ; Rhee, David ; Louis, David N. / Age-Dependent Prognostic Effects of Genetic Alterations in Glioblastoma. In: Clinical Cancer Research. 2004 ; Vol. 10, No. 1 I. pp. 228-233.
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