Adverse effects of citrate/gold nanoparticles on human dermal fibroblasts

Nadine Pernodet, Xiaohua Fang, Yuan Sun, Asya Bakhtina, Aditi Ramakrishnan, Jonathan Sokolov, Abraham Ulman, Miriam Rafailovich

Research output: Contribution to journalArticle

Abstract

Nanoscale engineering is one of the most dynamically growing areas at the interface between electronics, physics, biology, and medicine. As there are no safety regulations yet, concerns about future health problems are rising. We investigated the effects of citrate/gold nanoparticles at different concentrations and exposure times on human dermal fibroblasts. We found that, as a result of intracellular nanoparticle presence, actin stress fibers disappeared, thereby inducing major adverse effects on cell viability. Thus, properties such as cell spreading and adhesion, cell growth, and protein synthesis to form the extracellular matrix were altered dramatically. These results suggest that the internal cell activities have been damaged.

Original languageEnglish (US)
Pages (from-to)766-773
Number of pages8
JournalSmall
Volume2
Issue number6
DOIs
StatePublished - Jun 2006

Fingerprint

Fibroblasts
Citric Acid
Gold
Nanoparticles
Stress Fibers
Skin
Physics
Cell growth
Medical problems
Cell Adhesion
Medicine
Extracellular Matrix
Actins
Cell Survival
Electronic equipment
Adhesion
Cells
Proteins
Safety
Fibers

Keywords

  • Actin
  • Cell adhesion
  • Cell growth
  • Gold, nanoparticles

ASJC Scopus subject areas

  • Biomaterials
  • Engineering (miscellaneous)
  • Biotechnology
  • Medicine(all)

Cite this

Pernodet, N., Fang, X., Sun, Y., Bakhtina, A., Ramakrishnan, A., Sokolov, J., ... Rafailovich, M. (2006). Adverse effects of citrate/gold nanoparticles on human dermal fibroblasts. Small, 2(6), 766-773. https://doi.org/10.1002/smll.200500492

Adverse effects of citrate/gold nanoparticles on human dermal fibroblasts. / Pernodet, Nadine; Fang, Xiaohua; Sun, Yuan; Bakhtina, Asya; Ramakrishnan, Aditi; Sokolov, Jonathan; Ulman, Abraham; Rafailovich, Miriam.

In: Small, Vol. 2, No. 6, 06.2006, p. 766-773.

Research output: Contribution to journalArticle

Pernodet, N, Fang, X, Sun, Y, Bakhtina, A, Ramakrishnan, A, Sokolov, J, Ulman, A & Rafailovich, M 2006, 'Adverse effects of citrate/gold nanoparticles on human dermal fibroblasts', Small, vol. 2, no. 6, pp. 766-773. https://doi.org/10.1002/smll.200500492
Pernodet N, Fang X, Sun Y, Bakhtina A, Ramakrishnan A, Sokolov J et al. Adverse effects of citrate/gold nanoparticles on human dermal fibroblasts. Small. 2006 Jun;2(6):766-773. https://doi.org/10.1002/smll.200500492
Pernodet, Nadine ; Fang, Xiaohua ; Sun, Yuan ; Bakhtina, Asya ; Ramakrishnan, Aditi ; Sokolov, Jonathan ; Ulman, Abraham ; Rafailovich, Miriam. / Adverse effects of citrate/gold nanoparticles on human dermal fibroblasts. In: Small. 2006 ; Vol. 2, No. 6. pp. 766-773.
@article{fdadc609a37b412187b87658a0c1158e,
title = "Adverse effects of citrate/gold nanoparticles on human dermal fibroblasts",
abstract = "Nanoscale engineering is one of the most dynamically growing areas at the interface between electronics, physics, biology, and medicine. As there are no safety regulations yet, concerns about future health problems are rising. We investigated the effects of citrate/gold nanoparticles at different concentrations and exposure times on human dermal fibroblasts. We found that, as a result of intracellular nanoparticle presence, actin stress fibers disappeared, thereby inducing major adverse effects on cell viability. Thus, properties such as cell spreading and adhesion, cell growth, and protein synthesis to form the extracellular matrix were altered dramatically. These results suggest that the internal cell activities have been damaged.",
keywords = "Actin, Cell adhesion, Cell growth, Gold, nanoparticles",
author = "Nadine Pernodet and Xiaohua Fang and Yuan Sun and Asya Bakhtina and Aditi Ramakrishnan and Jonathan Sokolov and Abraham Ulman and Miriam Rafailovich",
year = "2006",
month = "6",
doi = "10.1002/smll.200500492",
language = "English (US)",
volume = "2",
pages = "766--773",
journal = "Small",
issn = "1613-6810",
publisher = "Wiley-VCH Verlag",
number = "6",

}

TY - JOUR

T1 - Adverse effects of citrate/gold nanoparticles on human dermal fibroblasts

AU - Pernodet, Nadine

AU - Fang, Xiaohua

AU - Sun, Yuan

AU - Bakhtina, Asya

AU - Ramakrishnan, Aditi

AU - Sokolov, Jonathan

AU - Ulman, Abraham

AU - Rafailovich, Miriam

PY - 2006/6

Y1 - 2006/6

N2 - Nanoscale engineering is one of the most dynamically growing areas at the interface between electronics, physics, biology, and medicine. As there are no safety regulations yet, concerns about future health problems are rising. We investigated the effects of citrate/gold nanoparticles at different concentrations and exposure times on human dermal fibroblasts. We found that, as a result of intracellular nanoparticle presence, actin stress fibers disappeared, thereby inducing major adverse effects on cell viability. Thus, properties such as cell spreading and adhesion, cell growth, and protein synthesis to form the extracellular matrix were altered dramatically. These results suggest that the internal cell activities have been damaged.

AB - Nanoscale engineering is one of the most dynamically growing areas at the interface between electronics, physics, biology, and medicine. As there are no safety regulations yet, concerns about future health problems are rising. We investigated the effects of citrate/gold nanoparticles at different concentrations and exposure times on human dermal fibroblasts. We found that, as a result of intracellular nanoparticle presence, actin stress fibers disappeared, thereby inducing major adverse effects on cell viability. Thus, properties such as cell spreading and adhesion, cell growth, and protein synthesis to form the extracellular matrix were altered dramatically. These results suggest that the internal cell activities have been damaged.

KW - Actin

KW - Cell adhesion

KW - Cell growth

KW - Gold, nanoparticles

UR - http://www.scopus.com/inward/record.url?scp=33646727853&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646727853&partnerID=8YFLogxK

U2 - 10.1002/smll.200500492

DO - 10.1002/smll.200500492

M3 - Article

VL - 2

SP - 766

EP - 773

JO - Small

JF - Small

SN - 1613-6810

IS - 6

ER -