Advances in vector-mediated gene transfer

Bruce J. Baum, Corinne M. Goldsmith, Marc R. Kok, Beatrijs M. Lodde, Norah M. Van Mello, Antonis Voutetakis, Jianghua Wang, Seiichi Yamano, Changyu Zheng

Research output: Contribution to journalArticle

Abstract

Clinical applications of gene transfer technology initially targeted the treatment of inherited monogenetic disorders and cancers refractory to conventional therapies. Today, gene transfer approaches are being developed for most tissues and for multiple disorders including those affecting quality of life. The focus herein is eventual application of gene transfer technology for the management of organ-directed autoimmunity. A specific example is presented: Sjögren's syndrome and localized salivary gland gene transfer. The status of relevant pre-clinical gene transfer studies is reviewed, with an emphasis on use of adenoviral and adeno-associated viral vectors. Current limitations of effective organ-directed gene transfer are also discussed.

Original languageEnglish (US)
Pages (from-to)145-149
Number of pages5
JournalImmunology Letters
Volume90
Issue number2-3
DOIs
StatePublished - Dec 15 2003

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Genes
Technology Transfer
Salivary Glands
Autoimmunity
Quality of Life
Therapeutics
Neoplasms

Keywords

  • Adeno-associated virus
  • Adenovirus
  • Autoimmune diseases
  • Viral vectors

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Baum, B. J., Goldsmith, C. M., Kok, M. R., Lodde, B. M., Van Mello, N. M., Voutetakis, A., ... Zheng, C. (2003). Advances in vector-mediated gene transfer. Immunology Letters, 90(2-3), 145-149. https://doi.org/10.1016/j.imlet.2003.08.006

Advances in vector-mediated gene transfer. / Baum, Bruce J.; Goldsmith, Corinne M.; Kok, Marc R.; Lodde, Beatrijs M.; Van Mello, Norah M.; Voutetakis, Antonis; Wang, Jianghua; Yamano, Seiichi; Zheng, Changyu.

In: Immunology Letters, Vol. 90, No. 2-3, 15.12.2003, p. 145-149.

Research output: Contribution to journalArticle

Baum, BJ, Goldsmith, CM, Kok, MR, Lodde, BM, Van Mello, NM, Voutetakis, A, Wang, J, Yamano, S & Zheng, C 2003, 'Advances in vector-mediated gene transfer', Immunology Letters, vol. 90, no. 2-3, pp. 145-149. https://doi.org/10.1016/j.imlet.2003.08.006
Baum BJ, Goldsmith CM, Kok MR, Lodde BM, Van Mello NM, Voutetakis A et al. Advances in vector-mediated gene transfer. Immunology Letters. 2003 Dec 15;90(2-3):145-149. https://doi.org/10.1016/j.imlet.2003.08.006
Baum, Bruce J. ; Goldsmith, Corinne M. ; Kok, Marc R. ; Lodde, Beatrijs M. ; Van Mello, Norah M. ; Voutetakis, Antonis ; Wang, Jianghua ; Yamano, Seiichi ; Zheng, Changyu. / Advances in vector-mediated gene transfer. In: Immunology Letters. 2003 ; Vol. 90, No. 2-3. pp. 145-149.
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