Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus

Victor M. Luna, Christoph Anacker, Nesha S. Burghardt, Hameda Khandaker, Valentine Andreu, Amira Millette, Paige Leary, Rebecca Ravenelle, Jessica C. Jimenez, Alessia Mastrodonato, Christine A. Denny, Andre Fenton, Helen E. Scharfman, Rene Hen

Research output: Contribution to journalArticle

Abstract

Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing.We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs through N-methyl-D-aspartate receptors. Thus, a critical function of abGCs may be to regulate the relative synaptic strengths of LEC-driven contextual information versus MEC-driven spatial information to shape distinct neural representations in the DG.

Original languageEnglish (US)
Pages (from-to)578-583
Number of pages6
JournalScience
Volume364
Issue number6440
DOIs
StatePublished - Jan 1 2019

Fingerprint

Dentate Gyrus
Neurons
Entorhinal Cortex
Metabotropic Glutamate Receptors
N-Methyl-D-Aspartate Receptors
Automatic Data Processing
Cognition
Young Adult

ASJC Scopus subject areas

  • General

Cite this

Luna, V. M., Anacker, C., Burghardt, N. S., Khandaker, H., Andreu, V., Millette, A., ... Hen, R. (2019). Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus. Science, 364(6440), 578-583. https://doi.org/10.1126/science.aat8789

Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus. / Luna, Victor M.; Anacker, Christoph; Burghardt, Nesha S.; Khandaker, Hameda; Andreu, Valentine; Millette, Amira; Leary, Paige; Ravenelle, Rebecca; Jimenez, Jessica C.; Mastrodonato, Alessia; Denny, Christine A.; Fenton, Andre; Scharfman, Helen E.; Hen, Rene.

In: Science, Vol. 364, No. 6440, 01.01.2019, p. 578-583.

Research output: Contribution to journalArticle

Luna, VM, Anacker, C, Burghardt, NS, Khandaker, H, Andreu, V, Millette, A, Leary, P, Ravenelle, R, Jimenez, JC, Mastrodonato, A, Denny, CA, Fenton, A, Scharfman, HE & Hen, R 2019, 'Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus', Science, vol. 364, no. 6440, pp. 578-583. https://doi.org/10.1126/science.aat8789
Luna VM, Anacker C, Burghardt NS, Khandaker H, Andreu V, Millette A et al. Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus. Science. 2019 Jan 1;364(6440):578-583. https://doi.org/10.1126/science.aat8789
Luna, Victor M. ; Anacker, Christoph ; Burghardt, Nesha S. ; Khandaker, Hameda ; Andreu, Valentine ; Millette, Amira ; Leary, Paige ; Ravenelle, Rebecca ; Jimenez, Jessica C. ; Mastrodonato, Alessia ; Denny, Christine A. ; Fenton, Andre ; Scharfman, Helen E. ; Hen, Rene. / Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus. In: Science. 2019 ; Vol. 364, No. 6440. pp. 578-583.
@article{93fd4f24514842eca574a3f9dba1b64a,
title = "Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus",
abstract = "Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing.We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs through N-methyl-D-aspartate receptors. Thus, a critical function of abGCs may be to regulate the relative synaptic strengths of LEC-driven contextual information versus MEC-driven spatial information to shape distinct neural representations in the DG.",
author = "Luna, {Victor M.} and Christoph Anacker and Burghardt, {Nesha S.} and Hameda Khandaker and Valentine Andreu and Amira Millette and Paige Leary and Rebecca Ravenelle and Jimenez, {Jessica C.} and Alessia Mastrodonato and Denny, {Christine A.} and Andre Fenton and Scharfman, {Helen E.} and Rene Hen",
year = "2019",
month = "1",
day = "1",
doi = "10.1126/science.aat8789",
language = "English (US)",
volume = "364",
pages = "578--583",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6440",

}

TY - JOUR

T1 - Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus

AU - Luna, Victor M.

AU - Anacker, Christoph

AU - Burghardt, Nesha S.

AU - Khandaker, Hameda

AU - Andreu, Valentine

AU - Millette, Amira

AU - Leary, Paige

AU - Ravenelle, Rebecca

AU - Jimenez, Jessica C.

AU - Mastrodonato, Alessia

AU - Denny, Christine A.

AU - Fenton, Andre

AU - Scharfman, Helen E.

AU - Hen, Rene

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing.We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs through N-methyl-D-aspartate receptors. Thus, a critical function of abGCs may be to regulate the relative synaptic strengths of LEC-driven contextual information versus MEC-driven spatial information to shape distinct neural representations in the DG.

AB - Young adult-born granule cells (abGCs) in the dentate gyrus (DG) have a profound impact on cognition and mood. However, it remains unclear how abGCs distinctively contribute to local DG information processing.We found that the actions of abGCs in the DG depend on the origin of incoming afferents. In response to lateral entorhinal cortex (LEC) inputs, abGCs exert monosynaptic inhibition of mature granule cells (mGCs) through group II metabotropic glutamate receptors. By contrast, in response to medial entorhinal cortex (MEC) inputs, abGCs directly excite mGCs through N-methyl-D-aspartate receptors. Thus, a critical function of abGCs may be to regulate the relative synaptic strengths of LEC-driven contextual information versus MEC-driven spatial information to shape distinct neural representations in the DG.

UR - http://www.scopus.com/inward/record.url?scp=85065861281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065861281&partnerID=8YFLogxK

U2 - 10.1126/science.aat8789

DO - 10.1126/science.aat8789

M3 - Article

VL - 364

SP - 578

EP - 583

JO - Science

JF - Science

SN - 0036-8075

IS - 6440

ER -