Acute stress time-dependently modulates multiple memory systems

Elizabeth V. Goldfarb, Yeva Mendelevich, Elizabeth Phelps

Research output: Contribution to journalArticle

Abstract

Acute stress has been shown to modulate the engagement of different memory systems, leading to preferential expression of stimulus-response (SR) rather than episodic context memory when both types of memory can be used. However, questions remain regarding the cognitive mechanism that underlies this bias in humans-specifically, how each form of memory is individually influenced by stress in order for SR memory to be dominant. Here we separately measured context and SR memory and investigated how each was influenced by acute stress after learning (Experiment 1) and before retrieval (Experiment 2). We found that postlearning stress, in tandem with increased adrenergic activity during learning, impaired consolidation of context memory and led to preferential expression of SR rather than context memory. Preretrieval stress also impaired context memory, albeit transiently. Neither postlearning nor preretrieval stress changed the expression of SR memory. However, individual differences in cortisol reactivity immediately after learning were associated with variability in initial SR learning. These results reveal novel cognitive mechanisms by which stress can modulate multiple memory systems.

Original languageEnglish (US)
Pages (from-to)1877-1894
Number of pages18
JournalJournal of Cognitive Neuroscience
Volume29
Issue number11
DOIs
StatePublished - Nov 1 2017

Fingerprint

Learning
Episodic Memory
Individuality
Adrenergic Agents
Hydrocortisone
Memory Consolidation

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Acute stress time-dependently modulates multiple memory systems. / Goldfarb, Elizabeth V.; Mendelevich, Yeva; Phelps, Elizabeth.

In: Journal of Cognitive Neuroscience, Vol. 29, No. 11, 01.11.2017, p. 1877-1894.

Research output: Contribution to journalArticle

Goldfarb, Elizabeth V. ; Mendelevich, Yeva ; Phelps, Elizabeth. / Acute stress time-dependently modulates multiple memory systems. In: Journal of Cognitive Neuroscience. 2017 ; Vol. 29, No. 11. pp. 1877-1894.
@article{b55a59f1990c4f18821325030e9ce238,
title = "Acute stress time-dependently modulates multiple memory systems",
abstract = "Acute stress has been shown to modulate the engagement of different memory systems, leading to preferential expression of stimulus-response (SR) rather than episodic context memory when both types of memory can be used. However, questions remain regarding the cognitive mechanism that underlies this bias in humans-specifically, how each form of memory is individually influenced by stress in order for SR memory to be dominant. Here we separately measured context and SR memory and investigated how each was influenced by acute stress after learning (Experiment 1) and before retrieval (Experiment 2). We found that postlearning stress, in tandem with increased adrenergic activity during learning, impaired consolidation of context memory and led to preferential expression of SR rather than context memory. Preretrieval stress also impaired context memory, albeit transiently. Neither postlearning nor preretrieval stress changed the expression of SR memory. However, individual differences in cortisol reactivity immediately after learning were associated with variability in initial SR learning. These results reveal novel cognitive mechanisms by which stress can modulate multiple memory systems.",
author = "Goldfarb, {Elizabeth V.} and Yeva Mendelevich and Elizabeth Phelps",
year = "2017",
month = "11",
day = "1",
doi = "10.1162/jocn_a_01167",
language = "English (US)",
volume = "29",
pages = "1877--1894",
journal = "Journal of Cognitive Neuroscience",
issn = "0898-929X",
publisher = "MIT Press Journals",
number = "11",

}

TY - JOUR

T1 - Acute stress time-dependently modulates multiple memory systems

AU - Goldfarb, Elizabeth V.

AU - Mendelevich, Yeva

AU - Phelps, Elizabeth

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Acute stress has been shown to modulate the engagement of different memory systems, leading to preferential expression of stimulus-response (SR) rather than episodic context memory when both types of memory can be used. However, questions remain regarding the cognitive mechanism that underlies this bias in humans-specifically, how each form of memory is individually influenced by stress in order for SR memory to be dominant. Here we separately measured context and SR memory and investigated how each was influenced by acute stress after learning (Experiment 1) and before retrieval (Experiment 2). We found that postlearning stress, in tandem with increased adrenergic activity during learning, impaired consolidation of context memory and led to preferential expression of SR rather than context memory. Preretrieval stress also impaired context memory, albeit transiently. Neither postlearning nor preretrieval stress changed the expression of SR memory. However, individual differences in cortisol reactivity immediately after learning were associated with variability in initial SR learning. These results reveal novel cognitive mechanisms by which stress can modulate multiple memory systems.

AB - Acute stress has been shown to modulate the engagement of different memory systems, leading to preferential expression of stimulus-response (SR) rather than episodic context memory when both types of memory can be used. However, questions remain regarding the cognitive mechanism that underlies this bias in humans-specifically, how each form of memory is individually influenced by stress in order for SR memory to be dominant. Here we separately measured context and SR memory and investigated how each was influenced by acute stress after learning (Experiment 1) and before retrieval (Experiment 2). We found that postlearning stress, in tandem with increased adrenergic activity during learning, impaired consolidation of context memory and led to preferential expression of SR rather than context memory. Preretrieval stress also impaired context memory, albeit transiently. Neither postlearning nor preretrieval stress changed the expression of SR memory. However, individual differences in cortisol reactivity immediately after learning were associated with variability in initial SR learning. These results reveal novel cognitive mechanisms by which stress can modulate multiple memory systems.

UR - http://www.scopus.com/inward/record.url?scp=85030328284&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030328284&partnerID=8YFLogxK

U2 - 10.1162/jocn_a_01167

DO - 10.1162/jocn_a_01167

M3 - Article

C2 - 28699809

AN - SCOPUS:85030328284

VL - 29

SP - 1877

EP - 1894

JO - Journal of Cognitive Neuroscience

JF - Journal of Cognitive Neuroscience

SN - 0898-929X

IS - 11

ER -