Actual versus ideal weight in the calculation of surface area: Effects on dose of 11 chemotherapy agents

R. S. Gelman, D. C. Tormey, Rebecca Betensky, E. G. Mansour, H. C. Falkson, G. Falkson, R. H. Creech, D. G. Haller

Research output: Contribution to journalArticle

Abstract

This study of 2382 breast, 182 rectal, 817 colon, and 351 lung cancer patients treated with combination chemotherapy on eight phase III Eastern Cooperative Oncology Group protocols indicates that 69% would receive a higher dose of at least one drug if surface area were calculated from actual weight rather than from the minimum of actual and ideal weight. Forty-eight percent of the patients would have at least a 10% increase in drug dose based on actual weight and only 8% would have at least a 25% increase in drug dose based on actual weight. Only on the premenopausal adjuvant breast cancer protocol and among women on the rectal adjuvant study do the differences in dose based on actual rather than ideal weight increase significantly with age. On the postmenopausal adjuvant breast study and on the lung cancer study, the differences in dose decrease significantly with age. For all age decades and both sexes within each protocol, the mean differences between dose based on actual and dose based on ideal weights were on the same order as the rounding factors for the 11 drugs studied. From the literature on the effects of doses of common chemotherapies on leukopenia, it appears that the percent of hematologic toxicity would not be raised to unacceptable levels by using actual weight to set doses.

Original languageEnglish (US)
Pages (from-to)907-911
Number of pages5
JournalCancer Treatment Reports
Volume71
Issue number10
StatePublished - Jan 1 1987

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Weights and Measures
Drug Therapy
Pharmaceutical Preparations
Lung Neoplasms
Breast
Leukopenia
Combination Drug Therapy
Colon
Breast Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Gelman, R. S., Tormey, D. C., Betensky, R., Mansour, E. G., Falkson, H. C., Falkson, G., ... Haller, D. G. (1987). Actual versus ideal weight in the calculation of surface area: Effects on dose of 11 chemotherapy agents. Cancer Treatment Reports, 71(10), 907-911.

Actual versus ideal weight in the calculation of surface area : Effects on dose of 11 chemotherapy agents. / Gelman, R. S.; Tormey, D. C.; Betensky, Rebecca; Mansour, E. G.; Falkson, H. C.; Falkson, G.; Creech, R. H.; Haller, D. G.

In: Cancer Treatment Reports, Vol. 71, No. 10, 01.01.1987, p. 907-911.

Research output: Contribution to journalArticle

Gelman, RS, Tormey, DC, Betensky, R, Mansour, EG, Falkson, HC, Falkson, G, Creech, RH & Haller, DG 1987, 'Actual versus ideal weight in the calculation of surface area: Effects on dose of 11 chemotherapy agents', Cancer Treatment Reports, vol. 71, no. 10, pp. 907-911.
Gelman, R. S. ; Tormey, D. C. ; Betensky, Rebecca ; Mansour, E. G. ; Falkson, H. C. ; Falkson, G. ; Creech, R. H. ; Haller, D. G. / Actual versus ideal weight in the calculation of surface area : Effects on dose of 11 chemotherapy agents. In: Cancer Treatment Reports. 1987 ; Vol. 71, No. 10. pp. 907-911.
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