Activity-based anorexia has differential effects on apical dendritic branching in dorsal and ventral hippocampal CA1

Tara G. Chowdhury, Nicole C. Barbarich-Marsteller, Thomas E. Chan, Chiye Aoki

Research output: Contribution to journalArticle

Abstract

Anorexia nervosa (AN) is an eating disorder to which adolescent females are particularly vulnerable. Like AN, activity-based anorexia (ABA), a rodent model of AN, results in elevation of stress hormones and has genetic links to anxiety disorders. The hippocampus plays a key role in the regulation of anxiety and responds with structural changes to hormones and stress, suggesting that it may play a role in AN. The hippocampus of ABA animals exhibits increased brain-derived neurotrophic factor and increased GABA receptor expression, but the structural effects of ABA have not been studied. We used Golgi staining of neurons to determine whether ABA in female rats during adolescence results in structural changes to the apical dendrites in hippocampal CA1 and contrasted to the effects of food restriction (FR) and exercise (EX), the environmental factors used to induce ABA. In the dorsal hippocampus, which preferentially mediates spatial learning and cognition, cells of ABA animals had less total dendritic length and fewer dendritic branches in stratum radiatum (SR) than in control (CON). In the ventral hippocampus, which preferentially mediates anxiety, ABA evoked more branching in SR than CON. In both dorsal and ventral regions, the main effect of exercise was localized to the SR while the main effect of food restriction occurred in the stratum lacunosum-moleculare. Taken together with data on spine density, these results indicate that ABA elicits pathway-specific changes in the hippocampus that may underlie the increased anxiety and reduced behavioral flexibility observed in ABA.

Original languageEnglish (US)
Pages (from-to)1935-1945
Number of pages11
JournalBrain Structure and Function
Volume219
Issue number6
DOIs
StatePublished - Nov 1 2014

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Anorexia
Anorexia Nervosa
Hippocampus
Anxiety
Hormones
Exercise
Food
GABA Receptors
Brain-Derived Neurotrophic Factor
Dendrites
Anxiety Disorders
Cognition
Rodentia
Spine
Staining and Labeling
Neurons

ASJC Scopus subject areas

  • Medicine(all)

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Activity-based anorexia has differential effects on apical dendritic branching in dorsal and ventral hippocampal CA1. / Chowdhury, Tara G.; Barbarich-Marsteller, Nicole C.; Chan, Thomas E.; Aoki, Chiye.

In: Brain Structure and Function, Vol. 219, No. 6, 01.11.2014, p. 1935-1945.

Research output: Contribution to journalArticle

Chowdhury, Tara G. ; Barbarich-Marsteller, Nicole C. ; Chan, Thomas E. ; Aoki, Chiye. / Activity-based anorexia has differential effects on apical dendritic branching in dorsal and ventral hippocampal CA1. In: Brain Structure and Function. 2014 ; Vol. 219, No. 6. pp. 1935-1945.
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