Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus

Jennifer N. Gelinas, Jessica L. Banko, Melinda M. Peters, Eric Klann, Edwin J. Weeber, Peter V. Nguyen

Research output: Contribution to journalArticle

Abstract

cAMP is a critical second messenger implicated in synaptic plasticity and memory in the mammalian brain. Substantial evidence links increases in intracellular cAMP to activation of cAMP-dependent protein kinase (PKA) and subsequent phosphorylation of downstream effectors (transcription factors, receptors, protein kinases) necessary for long-term potentiation (LTP) of synaptic strength. However, cAMP may also initiate signaling via a guanine nucleotide exchange protein directly activated by cAMP (Epac). The role of Epac in hippocampal synaptic plasticity is unknown. We found that in area CA1 of mouse hippocampal slices, activation of Epac enhances maintenance of LTP without affecting basal synaptic transmission. The persistence of this form of LTP requires extracellular signal-regulated protein kinase (ERK) and new protein synthesis, but not transcription. Because ERK is involved in translational control of long-lasting plasticity and memory, our data suggest that Epac is a crucial link between cAMP and ERK during some forms of protein synthesis-dependent LTP. Activation of Epac represents a novel signaling pathway for rapid regulation of the stability of enduring forms of LTP and, perhaps, of hippocampus-dependent long-term memories.

Original languageEnglish (US)
Pages (from-to)403-411
Number of pages9
JournalLearning and Memory
Volume15
Issue number6
DOIs
StatePublished - Jun 2008

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Cyclic AMP
Hippocampus
Long-Term Potentiation
Proteins
Neuronal Plasticity
Protein Kinases
Guanine Nucleotides
Long-Term Memory
Extracellular Signal-Regulated MAP Kinases
Second Messenger Systems
Cyclic AMP-Dependent Protein Kinases
Synaptic Transmission
Transcription Factors
Maintenance
Phosphorylation
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

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Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus. / Gelinas, Jennifer N.; Banko, Jessica L.; Peters, Melinda M.; Klann, Eric; Weeber, Edwin J.; Nguyen, Peter V.

In: Learning and Memory, Vol. 15, No. 6, 06.2008, p. 403-411.

Research output: Contribution to journalArticle

Gelinas, Jennifer N. ; Banko, Jessica L. ; Peters, Melinda M. ; Klann, Eric ; Weeber, Edwin J. ; Nguyen, Peter V. / Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus. In: Learning and Memory. 2008 ; Vol. 15, No. 6. pp. 403-411.
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