Activation of a tyrosine kinase-MAPK cascade enhances the induction of long-term synaptic facilitation and long-term memory in Aplysia

Angela L. Purcell, Shiv K. Sharma, Martha W. Bagnall, Michael A. Sutton, Thomas Carew

Research output: Contribution to journalArticle

Abstract

Tyrosine kinases have been implicated in cellular processes thought to underlie learning and memory. Here we show that tyrosine kinases play a direct role in long-term synaptic facilitation (LTF) and long-term memory (LTM) for sensitization in Aplysia. Tyrosine kinase activity is required for serotonin-induced LTF of sensorimotor (SN-MN) synapses, and enhancement of endogenous tyrosine kinase activity facilitates the induction of LTF. These effects are mediated, at least in part, through mitogen-activated protein kinase (MAPK) activation and are blocked by transcriptional and translational inhibitors. Moreover, brain-derived neurotrophic factor (BDNF) also enhances the induction of LTF in a MAPK-dependent fashion. Finally, activation of endogenous tyrosine kinases enhances the induction of long-term memory for sensitization, and this enhancement also requires MAPK activation. Thus, tyrosine kinases, acting through MAPK, play a pivotal role in LTF and LTM formation.

Original languageEnglish (US)
Pages (from-to)473-484
Number of pages12
JournalNeuron
Volume37
Issue number3
DOIs
StatePublished - Feb 6 2003

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Aplysia
Long-Term Memory
Mitogen-Activated Protein Kinases
Protein-Tyrosine Kinases
Brain-Derived Neurotrophic Factor
Synapses
Transcriptional Activation
Serotonin
Learning

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Activation of a tyrosine kinase-MAPK cascade enhances the induction of long-term synaptic facilitation and long-term memory in Aplysia. / Purcell, Angela L.; Sharma, Shiv K.; Bagnall, Martha W.; Sutton, Michael A.; Carew, Thomas.

In: Neuron, Vol. 37, No. 3, 06.02.2003, p. 473-484.

Research output: Contribution to journalArticle

Purcell, Angela L. ; Sharma, Shiv K. ; Bagnall, Martha W. ; Sutton, Michael A. ; Carew, Thomas. / Activation of a tyrosine kinase-MAPK cascade enhances the induction of long-term synaptic facilitation and long-term memory in Aplysia. In: Neuron. 2003 ; Vol. 37, No. 3. pp. 473-484.
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