Acetaminophen analgesia in neonatal circumcision

The effect on pain

C. R. Howard, F. M. Howard, Michael Weitzman

    Research output: Contribution to journalArticle

    Abstract

    Objective. Recognizing the concerns about the use of local anesthesia in neonatal circumcision, a painful procedure usually performed without analgesia or anesthesia, we undertook a study of acetaminophen for pain management of this procedure. Design. A prospective, randomized, double- blind, placebo-controlled, clinical trial of acetaminophen analgesia in 44 healthy full-term neonates undergoing circumcision was conducted. Beginning 2 hours before Gomco circumcision, neonates received either acetaminophen (15 mg/kg per dose, 0.15 mL/kg per dose) or placebo (0.15 mL/kg per dose) every 6 hours for 24 hours. Neonates were monitored intraoperatively for changes in heart rate, respiratory rate, and crying time. Postoperative pain was assessed at 30, 60, 90, 120, 360 minutes, and 24 hours using a standardized postoperative comfort scoring system. Feeding behavior was also assessed before and after circumcision by nursing observation. Results. Neonates in both groups showed significant increases in heart rate, respiratory rate, and crying during circumcision with no clinically significant differences observed between the groups. Postoperative comfort scores showed no significant differences between the groups until the 360-minute postoperative assessment, at which time the acetaminophen group had significantly improved scores (P < .05). Feeding behavior deteriorated in breast- and bottle-fed neonates in both groups, and acetaminophen did not seem to influence this deterioration. Conclusions. This study confirms that circumcision of the newborn causes severe and persistent pain. Acetaminophen was not found to ameliorate either the intraoperative or the immediate postoperative pain of circumcision, although it seems that it may provide some benefit after the immediate postoperative period.

    Original languageEnglish (US)
    Pages (from-to)641-646
    Number of pages6
    JournalPediatrics
    Volume93
    Issue number4
    StatePublished - Apr 15 1994

    Fingerprint

    Acetaminophen
    Analgesia
    Pain
    Crying
    Feeding Behavior
    Respiratory Rate
    Postoperative Pain
    Heart Rate
    Placebos
    Anesthesia and Analgesia
    Controlled Clinical Trials
    Local Anesthesia
    Pain Management
    Postoperative Period
    Breast
    Nursing
    Observation

    Keywords

    • acetaminophen
    • neonatal circumcision

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health

    Cite this

    Howard, C. R., Howard, F. M., & Weitzman, M. (1994). Acetaminophen analgesia in neonatal circumcision: The effect on pain. Pediatrics, 93(4), 641-646.

    Acetaminophen analgesia in neonatal circumcision : The effect on pain. / Howard, C. R.; Howard, F. M.; Weitzman, Michael.

    In: Pediatrics, Vol. 93, No. 4, 15.04.1994, p. 641-646.

    Research output: Contribution to journalArticle

    Howard, CR, Howard, FM & Weitzman, M 1994, 'Acetaminophen analgesia in neonatal circumcision: The effect on pain', Pediatrics, vol. 93, no. 4, pp. 641-646.
    Howard CR, Howard FM, Weitzman M. Acetaminophen analgesia in neonatal circumcision: The effect on pain. Pediatrics. 1994 Apr 15;93(4):641-646.
    Howard, C. R. ; Howard, F. M. ; Weitzman, Michael. / Acetaminophen analgesia in neonatal circumcision : The effect on pain. In: Pediatrics. 1994 ; Vol. 93, No. 4. pp. 641-646.
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