About the use of molecular workbenches and platforms in organic synthesis

Johann Mulzer, Karin Schein, Ingo Böhm, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

The concept of molecular workbenches is introduced. These workbenches are rigid templates onto which the substrate is fixed covalently and is thus arranged in a conformationally defined way. The workbench may be disconnectible (i.e. after the functionalization of the substrate it is removed by bond cleavage) or non-disconnectible. In this case the workbench is irreversibly incorporated into the target structure. This concept is illustrated by additions to (E) olefins (disconnectible workbench) and a synthesis of dihydrocodeinone (non-disconnectible workbench).

Original languageEnglish (US)
Pages (from-to)1487-1493
Number of pages7
JournalPure and Applied Chemistry
Volume70
Issue number8
StatePublished - Aug 1998

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Hydrocodone
Alkenes
Substrates
Olefins

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Mulzer, J., Schein, K., Böhm, I., & Trauner, D. (1998). About the use of molecular workbenches and platforms in organic synthesis. Pure and Applied Chemistry, 70(8), 1487-1493.

About the use of molecular workbenches and platforms in organic synthesis. / Mulzer, Johann; Schein, Karin; Böhm, Ingo; Trauner, Dirk.

In: Pure and Applied Chemistry, Vol. 70, No. 8, 08.1998, p. 1487-1493.

Research output: Contribution to journalArticle

Mulzer, J, Schein, K, Böhm, I & Trauner, D 1998, 'About the use of molecular workbenches and platforms in organic synthesis', Pure and Applied Chemistry, vol. 70, no. 8, pp. 1487-1493.
Mulzer J, Schein K, Böhm I, Trauner D. About the use of molecular workbenches and platforms in organic synthesis. Pure and Applied Chemistry. 1998 Aug;70(8):1487-1493.
Mulzer, Johann ; Schein, Karin ; Böhm, Ingo ; Trauner, Dirk. / About the use of molecular workbenches and platforms in organic synthesis. In: Pure and Applied Chemistry. 1998 ; Vol. 70, No. 8. pp. 1487-1493.
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