About the use of molecular workbenches and platforms in organic synthesis

Johann Mulzer, Karin Schein, Ingo Böhm, Dirk Trauner

Research output: Contribution to journalArticle

Abstract

The concept of molecular workbenches is introduced. These workbenches are rigid templates onto which the substrate is fixed covalently and is thus arranged in a conformationally defined way. The workbench may be disconnectible (i.e. after the functionalization of the substrate it is removed by bond cleavage) or non-disconnectible. In this case the workbench is irreversibly incorporated into the target structure. This concept is illustrated by additions to (E) olefins (disconnectible workbench) and a synthesis of dihydrocodeinone (non-disconnectible workbench).

Original languageEnglish (US)
Pages (from-to)1487-1493
Number of pages7
JournalPure and Applied Chemistry
Volume70
Issue number8
Publication statusPublished - Aug 1998

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ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Mulzer, J., Schein, K., Böhm, I., & Trauner, D. (1998). About the use of molecular workbenches and platforms in organic synthesis. Pure and Applied Chemistry, 70(8), 1487-1493.