A thermodynamic model of the lamellar to inverse hexagonal phase transition of lipid membrane-water systems

Gregory L. Kirk, Sol M. Gruner, D. L. Stein

    Research output: Contribution to journalArticle

    Abstract

    A theoretical model of the lamellar (Lα) to inverted hexagonal (HII) phase transition is developed for mixtures of water and biological lipids. A free energy per lipid molecule is calculated for each phase as the sum of four lattice-specific terms: a local elastic term and global terms involving the packing of hydrocarbon chains, Debye-shielded electrostatics, and hydration effects. A critical lipid concentration for the transition is indicated by the concentration where the net lamellar and hexagonal free energies are equal. The relevance of the model to membrane interactions in biological systems is discussed. Suggestions are made for introducing temperature dependence into the model, and experiments are proposed to investigate the principal opposing forces in the model.

    Original languageEnglish (US)
    Pages (from-to)1093-1102
    Number of pages10
    JournalBiochemistry
    Volume23
    Issue number6
    StatePublished - 1984

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    Phase Transition
    Membrane Lipids
    Thermodynamics
    Phase transitions
    Lipids
    Water
    Free energy
    Hydrocarbons
    Static Electricity
    Theoretical Models
    Biological systems
    Hydration
    Electrostatics
    Temperature
    Membranes
    Molecules
    Experiments

    ASJC Scopus subject areas

    • Biochemistry

    Cite this

    A thermodynamic model of the lamellar to inverse hexagonal phase transition of lipid membrane-water systems. / Kirk, Gregory L.; Gruner, Sol M.; Stein, D. L.

    In: Biochemistry, Vol. 23, No. 6, 1984, p. 1093-1102.

    Research output: Contribution to journalArticle

    Kirk, Gregory L. ; Gruner, Sol M. ; Stein, D. L. / A thermodynamic model of the lamellar to inverse hexagonal phase transition of lipid membrane-water systems. In: Biochemistry. 1984 ; Vol. 23, No. 6. pp. 1093-1102.
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