A testable prognostic model of nicotine dependence

Rachel Badovinac Ramoni, Nancy L. Saccone, Dorothy K. Hatsukami, Laura J. Bierut, Marco F. Ramoni

Research output: Contribution to journalArticle

Abstract

Individuals' dependence on nicotine, primarily through cigarette smoking, is a major source of morbidity and mortality worldwide. Many smokers attempt but fail to quit smoking, motivating researchers to identify the origins of this dependence. Because of the known heritability of nicotine-dependence phenotypes, considerable interest has been focused on discovering the genetic factors underpinning the trait. This goal, however, is not easily attained: no single factor is likely to explain any great proportion of dependence because nicotine dependence is thought to be a complex trait (i.e., the result of many interacting factors). Genomewide association studies are powerful tools in the search for the genomic bases of complex traits, and in this context, novel candidate genes have been identified through single nucleotide polymorphism (SNP) association analyses. Beyond association, however, genetic data can be used to generate predictive models of nicotine dependence. As expected in the context of a complex trait, individual SNPs fail to accurately predict nicotine dependence, demanding the use of multivariate models. Standard approaches, such as logistic regression, are unable to consider large numbers of SNPs given existing sample sizes. However, using Bayesian networks, one can overcome these limitations to generate a multivariate predictive model, which has markedly enhanced predictive accuracy on fitted values relative to that of individual SNPs. This approach, combined with the data being generated by genomewide association studies, promises to shed new light on the common, complex trait nicotine dependence.

Original languageEnglish (US)
Pages (from-to)283-292
Number of pages10
JournalJournal of Neurogenetics
Volume23
Issue number3
DOIs
StatePublished - Jan 2009

Fingerprint

Tobacco Use Disorder
Single Nucleotide Polymorphism
Smoking
Sample Size
Logistic Models
Research Personnel
Morbidity
Phenotype
Mortality
Genes

Keywords

  • Addiction
  • Genetics
  • Nicotine
  • Prediction

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Genetics

Cite this

Ramoni, R. B., Saccone, N. L., Hatsukami, D. K., Bierut, L. J., & Ramoni, M. F. (2009). A testable prognostic model of nicotine dependence. Journal of Neurogenetics, 23(3), 283-292. https://doi.org/10.1080/01677060802572911

A testable prognostic model of nicotine dependence. / Ramoni, Rachel Badovinac; Saccone, Nancy L.; Hatsukami, Dorothy K.; Bierut, Laura J.; Ramoni, Marco F.

In: Journal of Neurogenetics, Vol. 23, No. 3, 01.2009, p. 283-292.

Research output: Contribution to journalArticle

Ramoni, RB, Saccone, NL, Hatsukami, DK, Bierut, LJ & Ramoni, MF 2009, 'A testable prognostic model of nicotine dependence', Journal of Neurogenetics, vol. 23, no. 3, pp. 283-292. https://doi.org/10.1080/01677060802572911
Ramoni RB, Saccone NL, Hatsukami DK, Bierut LJ, Ramoni MF. A testable prognostic model of nicotine dependence. Journal of Neurogenetics. 2009 Jan;23(3):283-292. https://doi.org/10.1080/01677060802572911
Ramoni, Rachel Badovinac ; Saccone, Nancy L. ; Hatsukami, Dorothy K. ; Bierut, Laura J. ; Ramoni, Marco F. / A testable prognostic model of nicotine dependence. In: Journal of Neurogenetics. 2009 ; Vol. 23, No. 3. pp. 283-292.
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