A Systematic Review of DNA Methylation and Preterm Birth in African American Women

Veronica Barcelona de Mendoza, Michelle L. Wright, Comfort Agaba, Laura Prescott, Alexandra Desir, Cindy A. Crusto, Yan V. Sun, Jacquelyn Taylor

Research output: Contribution to journalReview article

Abstract

Background: The causes of many cases of preterm birth (PTB) remain enigmatic. Increased understanding of how epigenetic factors are associated with health outcomes has resulted in studies examining DNA methylation (DNAm) as a contributing factor to PTB. However, few studies on PTB and DNAm have included African American women, the group with the highest rate of PTB. Methods: The objective of this review was to systematically analyze the existing studies on DNAm and PTB among African American women. Results: Studies (N = 10) were limited by small sample size, cross-sectional study designs, inconsistent methodologies for epigenomic analysis, and evaluation of different tissue types across studies. African Americans comprised less than half of the sample in 50% of the studies reviewed. Despite these limitations, there is evidence for an association between DNAm patterns and PTB. Conclusions: Future research on DNAm patterns and PTB should use longitudinal study designs, repeated DNAm testing, and a clinically relevant definition of PTB and should include large samples of high-risk African American women to better understand the mechanisms for PTB in this population.

Original languageEnglish (US)
Pages (from-to)308-317
Number of pages10
JournalBiological Research for Nursing
Volume19
Issue number3
DOIs
StatePublished - May 1 2017

Fingerprint

Premature Birth
DNA Methylation
African Americans
Epigenomics
Sample Size
Longitudinal Studies
Cross-Sectional Studies
Health

Keywords

  • African Americans
  • DNA methylation
  • gestational age
  • pregnancy
  • preterm birth
  • race

ASJC Scopus subject areas

  • Research and Theory

Cite this

Barcelona de Mendoza, V., Wright, M. L., Agaba, C., Prescott, L., Desir, A., Crusto, C. A., ... Taylor, J. (2017). A Systematic Review of DNA Methylation and Preterm Birth in African American Women. Biological Research for Nursing, 19(3), 308-317. https://doi.org/10.1177/1099800416669049

A Systematic Review of DNA Methylation and Preterm Birth in African American Women. / Barcelona de Mendoza, Veronica; Wright, Michelle L.; Agaba, Comfort; Prescott, Laura; Desir, Alexandra; Crusto, Cindy A.; Sun, Yan V.; Taylor, Jacquelyn.

In: Biological Research for Nursing, Vol. 19, No. 3, 01.05.2017, p. 308-317.

Research output: Contribution to journalReview article

Barcelona de Mendoza, V, Wright, ML, Agaba, C, Prescott, L, Desir, A, Crusto, CA, Sun, YV & Taylor, J 2017, 'A Systematic Review of DNA Methylation and Preterm Birth in African American Women', Biological Research for Nursing, vol. 19, no. 3, pp. 308-317. https://doi.org/10.1177/1099800416669049
Barcelona de Mendoza V, Wright ML, Agaba C, Prescott L, Desir A, Crusto CA et al. A Systematic Review of DNA Methylation and Preterm Birth in African American Women. Biological Research for Nursing. 2017 May 1;19(3):308-317. https://doi.org/10.1177/1099800416669049
Barcelona de Mendoza, Veronica ; Wright, Michelle L. ; Agaba, Comfort ; Prescott, Laura ; Desir, Alexandra ; Crusto, Cindy A. ; Sun, Yan V. ; Taylor, Jacquelyn. / A Systematic Review of DNA Methylation and Preterm Birth in African American Women. In: Biological Research for Nursing. 2017 ; Vol. 19, No. 3. pp. 308-317.
@article{038e61f986eb4976858956808e11e643,
title = "A Systematic Review of DNA Methylation and Preterm Birth in African American Women",
abstract = "Background: The causes of many cases of preterm birth (PTB) remain enigmatic. Increased understanding of how epigenetic factors are associated with health outcomes has resulted in studies examining DNA methylation (DNAm) as a contributing factor to PTB. However, few studies on PTB and DNAm have included African American women, the group with the highest rate of PTB. Methods: The objective of this review was to systematically analyze the existing studies on DNAm and PTB among African American women. Results: Studies (N = 10) were limited by small sample size, cross-sectional study designs, inconsistent methodologies for epigenomic analysis, and evaluation of different tissue types across studies. African Americans comprised less than half of the sample in 50{\%} of the studies reviewed. Despite these limitations, there is evidence for an association between DNAm patterns and PTB. Conclusions: Future research on DNAm patterns and PTB should use longitudinal study designs, repeated DNAm testing, and a clinically relevant definition of PTB and should include large samples of high-risk African American women to better understand the mechanisms for PTB in this population.",
keywords = "African Americans, DNA methylation, gestational age, pregnancy, preterm birth, race",
author = "{Barcelona de Mendoza}, Veronica and Wright, {Michelle L.} and Comfort Agaba and Laura Prescott and Alexandra Desir and Crusto, {Cindy A.} and Sun, {Yan V.} and Jacquelyn Taylor",
year = "2017",
month = "5",
day = "1",
doi = "10.1177/1099800416669049",
language = "English (US)",
volume = "19",
pages = "308--317",
journal = "Biological Research for Nursing",
issn = "1099-8004",
publisher = "SAGE Publications Inc.",
number = "3",

}

TY - JOUR

T1 - A Systematic Review of DNA Methylation and Preterm Birth in African American Women

AU - Barcelona de Mendoza, Veronica

AU - Wright, Michelle L.

AU - Agaba, Comfort

AU - Prescott, Laura

AU - Desir, Alexandra

AU - Crusto, Cindy A.

AU - Sun, Yan V.

AU - Taylor, Jacquelyn

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Background: The causes of many cases of preterm birth (PTB) remain enigmatic. Increased understanding of how epigenetic factors are associated with health outcomes has resulted in studies examining DNA methylation (DNAm) as a contributing factor to PTB. However, few studies on PTB and DNAm have included African American women, the group with the highest rate of PTB. Methods: The objective of this review was to systematically analyze the existing studies on DNAm and PTB among African American women. Results: Studies (N = 10) were limited by small sample size, cross-sectional study designs, inconsistent methodologies for epigenomic analysis, and evaluation of different tissue types across studies. African Americans comprised less than half of the sample in 50% of the studies reviewed. Despite these limitations, there is evidence for an association between DNAm patterns and PTB. Conclusions: Future research on DNAm patterns and PTB should use longitudinal study designs, repeated DNAm testing, and a clinically relevant definition of PTB and should include large samples of high-risk African American women to better understand the mechanisms for PTB in this population.

AB - Background: The causes of many cases of preterm birth (PTB) remain enigmatic. Increased understanding of how epigenetic factors are associated with health outcomes has resulted in studies examining DNA methylation (DNAm) as a contributing factor to PTB. However, few studies on PTB and DNAm have included African American women, the group with the highest rate of PTB. Methods: The objective of this review was to systematically analyze the existing studies on DNAm and PTB among African American women. Results: Studies (N = 10) were limited by small sample size, cross-sectional study designs, inconsistent methodologies for epigenomic analysis, and evaluation of different tissue types across studies. African Americans comprised less than half of the sample in 50% of the studies reviewed. Despite these limitations, there is evidence for an association between DNAm patterns and PTB. Conclusions: Future research on DNAm patterns and PTB should use longitudinal study designs, repeated DNAm testing, and a clinically relevant definition of PTB and should include large samples of high-risk African American women to better understand the mechanisms for PTB in this population.

KW - African Americans

KW - DNA methylation

KW - gestational age

KW - pregnancy

KW - preterm birth

KW - race

UR - http://www.scopus.com/inward/record.url?scp=85018773814&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018773814&partnerID=8YFLogxK

U2 - 10.1177/1099800416669049

DO - 10.1177/1099800416669049

M3 - Review article

C2 - 27646016

AN - SCOPUS:85018773814

VL - 19

SP - 308

EP - 317

JO - Biological Research for Nursing

JF - Biological Research for Nursing

SN - 1099-8004

IS - 3

ER -