A synaptic explanation of suppression in visual cortex

Matteo Carandini, David J. Heeger, Walter Senn

Research output: Contribution to journalArticle

Abstract

The responses of neurons in the primary visual cortex (V1) are suppressed by mask stimuli that do not elicit responses if presented alone. This suppression is widely believed to be mediated by intracortical inhibition. As an alternative, we propose that it can be explained by thalamocortical synaptic depression. This explanation correctly predicts that suppression is monocular, immune to cortical adaptation, and occurs for mask stimuli that elicit responses in the thalamus but not in the cortex. Depression also explains other phenomena previously ascribed to intracortical inhibition. It explains why responses saturate at high stimulus contrast, whereas selectivity for orientation and spatial frequency is invariant with contrast. It explains why transient responses to flashed stimuli are nonlinear, whereas spatial summation is primarily linear. These results suggest that the very first synapses into the cortex, and not the cortical network, may account for important response properties of V1 neurons.

Original languageEnglish (US)
Pages (from-to)10053-10065
Number of pages13
JournalJournal of Neuroscience
Volume22
Issue number22
StatePublished - Nov 15 2002

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Visual Cortex
Masks
Neurons
Thalamus
Synapses

Keywords

  • Contrast
  • Cortex
  • Depression
  • Inhibition
  • Masking
  • Orientation
  • Suppression
  • Thalamus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A synaptic explanation of suppression in visual cortex. / Carandini, Matteo; Heeger, David J.; Senn, Walter.

In: Journal of Neuroscience, Vol. 22, No. 22, 15.11.2002, p. 10053-10065.

Research output: Contribution to journalArticle

Carandini, M, Heeger, DJ & Senn, W 2002, 'A synaptic explanation of suppression in visual cortex', Journal of Neuroscience, vol. 22, no. 22, pp. 10053-10065.
Carandini, Matteo ; Heeger, David J. ; Senn, Walter. / A synaptic explanation of suppression in visual cortex. In: Journal of Neuroscience. 2002 ; Vol. 22, No. 22. pp. 10053-10065.
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