A 1H NMR study on the interaction of aminoxyl paramagnetic probes with unfolded peptides

Gennaro Esposito, Henriette Molinari, Monica Pegna, Neri Niccolai, Lucia Zetta

Research output: Contribution to journalArticle


The use of soluble spin labels to filter out the cross peaks of outer proton nuclei in 2D NMR spectra has been proposed as a general method to obtain structural information for complex molecules. Here the paramagnetic effects observed on backbone protons of an unfolded 27 amino acid peptide are discussed. The lack of any differential intensity change of the NH-Hα cross-peaks in TOCSY spectra is suggested as an additional general criterion for the identification of unfolded structures.

Original languageEnglish (US)
Pages (from-to)1531-1534
Number of pages4
JournalJournal of the Chemical Society, Perkin Transactions 2
Issue number8
StatePublished - Dec 1 1993


ASJC Scopus subject areas

  • Chemistry(all)

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