A structural MRI study of human brain development from birth to 2 years

Rebecca C. Knickmeyer, Sylvain Gouttard, Chaeryon Kang, Dianne Evans, Kathy Wilber, J. Keith Smith, Robert M. Hamer, Weili Lin, Guido Gerig, John H. Gilmore

    Research output: Contribution to journalArticle

    Abstract

    Brain development in the first 2 years after birth is extremely dynamic and likely plays an important role in neurodevelopmental disorders, including autism and schizophrenia. Knowledge regarding this period is currently quite limited. We studied structural brain development in healthy subjects from birth to 2. Ninety-eight children received structural MRI scans on a Siemens head-only 3T scanner with magnetization prepared rapid gradient echo T1-weighted, and turbo spin echo, dual-echo (proton density and T2 weighted) sequences: 84 children at 2-4 weeks, 35 at 1 year and 26 at 2 years of age. Tissue segmentation was accomplished using a novel automated approach. Lateral ventricle, caudate, and hippocampal volumes were also determined. Total brain volume increased 101% in the first year, with a 15% increase in the second. The majority of hemispheric growth was accounted for by gray matter, which increased 149% in the first year; hemispheric white matter volume increased by only 11%. Cerebellum volume increased 240% in the first year. Lateral ventricle volume increased 280% in the first year, with a small decrease in the second. The caudate increased 19% and the hippocampus 13% from age 1 to age 2. There was robust growth of the human brain in the first two years of life, driven mainly by gray matter growth. In contrast, white matter growth was much slower. Cerebellum volume also increased substantially in the first year of life. These results suggest the structural underpinnings of cognitive and motor development in early childhood, as well as the potential pathogenesis of neurodevelopmental disorders.

    Original languageEnglish (US)
    Pages (from-to)12176-12182
    Number of pages7
    JournalJournal of Neuroscience
    Volume28
    Issue number47
    DOIs
    StatePublished - Nov 19 2008

    Fingerprint

    Human Development
    Parturition
    Lateral Ventricles
    Brain
    Growth
    Cerebellum
    Autistic Disorder
    Protons
    Hippocampus
    Schizophrenia
    Healthy Volunteers
    Head
    Magnetic Resonance Imaging
    White Matter
    Neurodevelopmental Disorders
    Gray Matter

    Keywords

    • Brain development
    • Caudate
    • Children
    • Cortex
    • Hippocampus
    • Magnetic resonance imaging

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Knickmeyer, R. C., Gouttard, S., Kang, C., Evans, D., Wilber, K., Smith, J. K., ... Gilmore, J. H. (2008). A structural MRI study of human brain development from birth to 2 years. Journal of Neuroscience, 28(47), 12176-12182. https://doi.org/10.1523/JNEUROSCI.3479-08.2008

    A structural MRI study of human brain development from birth to 2 years. / Knickmeyer, Rebecca C.; Gouttard, Sylvain; Kang, Chaeryon; Evans, Dianne; Wilber, Kathy; Smith, J. Keith; Hamer, Robert M.; Lin, Weili; Gerig, Guido; Gilmore, John H.

    In: Journal of Neuroscience, Vol. 28, No. 47, 19.11.2008, p. 12176-12182.

    Research output: Contribution to journalArticle

    Knickmeyer, RC, Gouttard, S, Kang, C, Evans, D, Wilber, K, Smith, JK, Hamer, RM, Lin, W, Gerig, G & Gilmore, JH 2008, 'A structural MRI study of human brain development from birth to 2 years', Journal of Neuroscience, vol. 28, no. 47, pp. 12176-12182. https://doi.org/10.1523/JNEUROSCI.3479-08.2008
    Knickmeyer RC, Gouttard S, Kang C, Evans D, Wilber K, Smith JK et al. A structural MRI study of human brain development from birth to 2 years. Journal of Neuroscience. 2008 Nov 19;28(47):12176-12182. https://doi.org/10.1523/JNEUROSCI.3479-08.2008
    Knickmeyer, Rebecca C. ; Gouttard, Sylvain ; Kang, Chaeryon ; Evans, Dianne ; Wilber, Kathy ; Smith, J. Keith ; Hamer, Robert M. ; Lin, Weili ; Gerig, Guido ; Gilmore, John H. / A structural MRI study of human brain development from birth to 2 years. In: Journal of Neuroscience. 2008 ; Vol. 28, No. 47. pp. 12176-12182.
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