A solid-state NMR method to determine domain sizes in multi-component polymer formulations

Judith Schlagnitweit, Mingxue Tang, Maria Baias, Sara Richardson, Staffan Schantz, Lyndon Emsley

    Research output: Contribution to journalArticle

    Abstract

    Polymer domain sizes are related to many of the physical properties of polymers. Here we present a solid-state NMR experiment that is capable of measuring domain sizes in multi-component mixtures. The method combines selective excitation of carbon magnetization to isolate a specific component with proton spin diffusion to report on domain size. We demonstrate the method in the context of controlled release formulations, which represents one of today's challenges in pharmaceutical science. We show that we can measure domain sizes of interest in the different components of industrial pharmaceutical formulations at natural isotopic abundance containing various (modified) cellulose derivatives, such as microcrystalline cellulose matrixes that are film-coated with a mixture of ethyl cellulose (EC) and hydroxypropyl cellulose (HPC).

    Original languageEnglish (US)
    Pages (from-to)43-48
    Number of pages6
    JournalJournal of Magnetic Resonance
    Volume261
    DOIs
    StatePublished - Dec 1 2015

    Fingerprint

    cellulose
    Polymers
    Nuclear magnetic resonance
    Cellulose derivatives
    solid state
    formulations
    Drug Compounding
    nuclear magnetic resonance
    polymers
    Cellulose
    Pharmaceutical Preparations
    Protons
    Magnetization
    Carbon
    Physical properties
    physical properties
    Experiments
    magnetization
    protons
    carbon

    Keywords

    • Cellulose
    • Domain sizes
    • Solid-state NMR
    • Spin diffusion

    ASJC Scopus subject areas

    • Biophysics
    • Biochemistry
    • Nuclear and High Energy Physics
    • Condensed Matter Physics

    Cite this

    A solid-state NMR method to determine domain sizes in multi-component polymer formulations. / Schlagnitweit, Judith; Tang, Mingxue; Baias, Maria; Richardson, Sara; Schantz, Staffan; Emsley, Lyndon.

    In: Journal of Magnetic Resonance, Vol. 261, 01.12.2015, p. 43-48.

    Research output: Contribution to journalArticle

    Schlagnitweit, J, Tang, M, Baias, M, Richardson, S, Schantz, S & Emsley, L 2015, 'A solid-state NMR method to determine domain sizes in multi-component polymer formulations', Journal of Magnetic Resonance, vol. 261, pp. 43-48. https://doi.org/10.1016/j.jmr.2015.09.014
    Schlagnitweit, Judith ; Tang, Mingxue ; Baias, Maria ; Richardson, Sara ; Schantz, Staffan ; Emsley, Lyndon. / A solid-state NMR method to determine domain sizes in multi-component polymer formulations. In: Journal of Magnetic Resonance. 2015 ; Vol. 261. pp. 43-48.
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    AU - Emsley, Lyndon

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