A solid-state NMR method to determine domain sizes in multi-component polymer formulations

Judith Schlagnitweit, Mingxue Tang, Maria Baias, Sara Richardson, Staffan Schantz, Lyndon Emsley

Research output: Contribution to journalArticle

Abstract

Polymer domain sizes are related to many of the physical properties of polymers. Here we present a solid-state NMR experiment that is capable of measuring domain sizes in multi-component mixtures. The method combines selective excitation of carbon magnetization to isolate a specific component with proton spin diffusion to report on domain size. We demonstrate the method in the context of controlled release formulations, which represents one of today's challenges in pharmaceutical science. We show that we can measure domain sizes of interest in the different components of industrial pharmaceutical formulations at natural isotopic abundance containing various (modified) cellulose derivatives, such as microcrystalline cellulose matrixes that are film-coated with a mixture of ethyl cellulose (EC) and hydroxypropyl cellulose (HPC).

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalJournal of Magnetic Resonance
Volume261
DOIs
StatePublished - Dec 1 2015

Fingerprint

cellulose
Polymers
Nuclear magnetic resonance
Cellulose derivatives
solid state
formulations
Drug Compounding
nuclear magnetic resonance
polymers
Cellulose
Pharmaceutical Preparations
Protons
Magnetization
Carbon
Physical properties
physical properties
Experiments
magnetization
protons
carbon

Keywords

  • Cellulose
  • Domain sizes
  • Solid-state NMR
  • Spin diffusion

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

Cite this

A solid-state NMR method to determine domain sizes in multi-component polymer formulations. / Schlagnitweit, Judith; Tang, Mingxue; Baias, Maria; Richardson, Sara; Schantz, Staffan; Emsley, Lyndon.

In: Journal of Magnetic Resonance, Vol. 261, 01.12.2015, p. 43-48.

Research output: Contribution to journalArticle

Schlagnitweit, Judith ; Tang, Mingxue ; Baias, Maria ; Richardson, Sara ; Schantz, Staffan ; Emsley, Lyndon. / A solid-state NMR method to determine domain sizes in multi-component polymer formulations. In: Journal of Magnetic Resonance. 2015 ; Vol. 261. pp. 43-48.
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