A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function

J. Broichhagen, J. A. Frank, N. R. Johnston, R. K. Mitchell, K. Šmid, P. Marchetti, M. Bugliani, G. A. Rutter, Dirk Trauner, D. J. Hodson

Research output: Contribution to journalArticle

Abstract

Azobenzene photoresponsive elements can be installed on sulfonylureas, yielding optical control over pancreatic beta cell function and insulin release. An obstacle to such photopharmacological approaches remains the use of ultraviolet-blue illumination. Herein, we synthesize and test a novel yellow light-activated sulfonylurea based on a heterocyclic azobenzene bearing a push-pull system.

Original languageEnglish (US)
Pages (from-to)6018-6021
Number of pages4
JournalChemical Communications
Volume51
Issue number27
DOIs
StatePublished - Apr 7 2015

Fingerprint

Azobenzene
Remote control
Bearings (structural)
Insulin
Lighting
azobenzene

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Broichhagen, J., Frank, J. A., Johnston, N. R., Mitchell, R. K., Šmid, K., Marchetti, P., ... Hodson, D. J. (2015). A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function. Chemical Communications, 51(27), 6018-6021. https://doi.org/10.1039/c5cc01224d

A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function. / Broichhagen, J.; Frank, J. A.; Johnston, N. R.; Mitchell, R. K.; Šmid, K.; Marchetti, P.; Bugliani, M.; Rutter, G. A.; Trauner, Dirk; Hodson, D. J.

In: Chemical Communications, Vol. 51, No. 27, 07.04.2015, p. 6018-6021.

Research output: Contribution to journalArticle

Broichhagen, J, Frank, JA, Johnston, NR, Mitchell, RK, Šmid, K, Marchetti, P, Bugliani, M, Rutter, GA, Trauner, D & Hodson, DJ 2015, 'A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function', Chemical Communications, vol. 51, no. 27, pp. 6018-6021. https://doi.org/10.1039/c5cc01224d
Broichhagen J, Frank JA, Johnston NR, Mitchell RK, Šmid K, Marchetti P et al. A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function. Chemical Communications. 2015 Apr 7;51(27):6018-6021. https://doi.org/10.1039/c5cc01224d
Broichhagen, J. ; Frank, J. A. ; Johnston, N. R. ; Mitchell, R. K. ; Šmid, K. ; Marchetti, P. ; Bugliani, M. ; Rutter, G. A. ; Trauner, Dirk ; Hodson, D. J. / A red-shifted photochromic sulfonylurea for the remote control of pancreatic beta cell function. In: Chemical Communications. 2015 ; Vol. 51, No. 27. pp. 6018-6021.
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