A randomized trial of a hepatitis care coordination model in methadone maintenance treatment

Carmen L. Masson, Kevin L. Delucchi, Courtney Mcknight, Jennifer Hettema, Mandana Khalili, Albert Min, Ashly E. Jordan, Nicole Pepper, Jessica Hall, Nicholas S. Hengl, Christopher Young, Michael S. Shopshire, Jennifer K. Manuel, Lara Coffin, Hali Hammer, Bradley Shapiro, Randy M. Seewald, Henry C. Bodenheimer, James L. Sorensen, Don Des Jarlais & 1 others David C. Perlman

Research output: Contribution to journalArticle

Abstract

Objectives. We evaluated the efficacy of a hepatitis care coordination intervention to improve linkage to hepatitis A virus (HAV) and hepatitis B virus (HBV) vaccination and clinical evaluation of hepatitis C virus (HCV) infection among methadone maintenance patients. Methods. We conducted a randomized controlled trial of 489 participants from methadone maintenance treatment programs in San Francisco, California, and New York City from February 2008 through June 2011. We randomized participants to a control arm (n = 245) and an intervention arm (n = 244), which included on-site screening, motivational-enhanced education and counseling, on-site vaccination, and case management services. Results. Compared with the control group, intervention group participants were significantly more likely (odds ratio [OR] = 41.8; 95% confidence interval [CI] = 19.4, 90.0) to receive their first vaccine dose within 30 days and to receive an HCV evaluation within 6 months (OR = 4.10; 95% CI = 2.35, 7.17). A combined intervention adherence outcome that measured adherence to HAV-HBV vaccination, HCV evaluation, or both strongly favored the intervention group (OR = 8.70; 95% CI = 5.56, 13.61). Conclusions. Hepatitis care coordination was efficacious in increasing adherence to HAV-HBV vaccination and HCV clinical evaluation among methadone patients.

Original languageEnglish (US)
JournalAmerican Journal of Public Health
Volume103
Issue number10
DOIs
StatePublished - Oct 1 2013

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Methadone
Hepatitis A virus
Hepacivirus
Hepatitis
Vaccination
Hepatitis B virus
Odds Ratio
Confidence Intervals
San Francisco
Case Management
Virus Diseases
Therapeutics
Counseling
Vaccines
Randomized Controlled Trials
Education
Control Groups

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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A randomized trial of a hepatitis care coordination model in methadone maintenance treatment. / Masson, Carmen L.; Delucchi, Kevin L.; Mcknight, Courtney; Hettema, Jennifer; Khalili, Mandana; Min, Albert; Jordan, Ashly E.; Pepper, Nicole; Hall, Jessica; Hengl, Nicholas S.; Young, Christopher; Shopshire, Michael S.; Manuel, Jennifer K.; Coffin, Lara; Hammer, Hali; Shapiro, Bradley; Seewald, Randy M.; Bodenheimer, Henry C.; Sorensen, James L.; Des Jarlais, Don; Perlman, David C.

In: American Journal of Public Health, Vol. 103, No. 10, 01.10.2013.

Research output: Contribution to journalArticle

Masson, CL, Delucchi, KL, Mcknight, C, Hettema, J, Khalili, M, Min, A, Jordan, AE, Pepper, N, Hall, J, Hengl, NS, Young, C, Shopshire, MS, Manuel, JK, Coffin, L, Hammer, H, Shapiro, B, Seewald, RM, Bodenheimer, HC, Sorensen, JL, Des Jarlais, D & Perlman, DC 2013, 'A randomized trial of a hepatitis care coordination model in methadone maintenance treatment', American Journal of Public Health, vol. 103, no. 10. https://doi.org/10.2105/AJPH.2013.301458
Masson, Carmen L. ; Delucchi, Kevin L. ; Mcknight, Courtney ; Hettema, Jennifer ; Khalili, Mandana ; Min, Albert ; Jordan, Ashly E. ; Pepper, Nicole ; Hall, Jessica ; Hengl, Nicholas S. ; Young, Christopher ; Shopshire, Michael S. ; Manuel, Jennifer K. ; Coffin, Lara ; Hammer, Hali ; Shapiro, Bradley ; Seewald, Randy M. ; Bodenheimer, Henry C. ; Sorensen, James L. ; Des Jarlais, Don ; Perlman, David C. / A randomized trial of a hepatitis care coordination model in methadone maintenance treatment. In: American Journal of Public Health. 2013 ; Vol. 103, No. 10.
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abstract = "Objectives. We evaluated the efficacy of a hepatitis care coordination intervention to improve linkage to hepatitis A virus (HAV) and hepatitis B virus (HBV) vaccination and clinical evaluation of hepatitis C virus (HCV) infection among methadone maintenance patients. Methods. We conducted a randomized controlled trial of 489 participants from methadone maintenance treatment programs in San Francisco, California, and New York City from February 2008 through June 2011. We randomized participants to a control arm (n = 245) and an intervention arm (n = 244), which included on-site screening, motivational-enhanced education and counseling, on-site vaccination, and case management services. Results. Compared with the control group, intervention group participants were significantly more likely (odds ratio [OR] = 41.8; 95{\%} confidence interval [CI] = 19.4, 90.0) to receive their first vaccine dose within 30 days and to receive an HCV evaluation within 6 months (OR = 4.10; 95{\%} CI = 2.35, 7.17). A combined intervention adherence outcome that measured adherence to HAV-HBV vaccination, HCV evaluation, or both strongly favored the intervention group (OR = 8.70; 95{\%} CI = 5.56, 13.61). Conclusions. Hepatitis care coordination was efficacious in increasing adherence to HAV-HBV vaccination and HCV clinical evaluation among methadone patients.",
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AU - Khalili, Mandana

AU - Min, Albert

AU - Jordan, Ashly E.

AU - Pepper, Nicole

AU - Hall, Jessica

AU - Hengl, Nicholas S.

AU - Young, Christopher

AU - Shopshire, Michael S.

AU - Manuel, Jennifer K.

AU - Coffin, Lara

AU - Hammer, Hali

AU - Shapiro, Bradley

AU - Seewald, Randy M.

AU - Bodenheimer, Henry C.

AU - Sorensen, James L.

AU - Des Jarlais, Don

AU - Perlman, David C.

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N2 - Objectives. We evaluated the efficacy of a hepatitis care coordination intervention to improve linkage to hepatitis A virus (HAV) and hepatitis B virus (HBV) vaccination and clinical evaluation of hepatitis C virus (HCV) infection among methadone maintenance patients. Methods. We conducted a randomized controlled trial of 489 participants from methadone maintenance treatment programs in San Francisco, California, and New York City from February 2008 through June 2011. We randomized participants to a control arm (n = 245) and an intervention arm (n = 244), which included on-site screening, motivational-enhanced education and counseling, on-site vaccination, and case management services. Results. Compared with the control group, intervention group participants were significantly more likely (odds ratio [OR] = 41.8; 95% confidence interval [CI] = 19.4, 90.0) to receive their first vaccine dose within 30 days and to receive an HCV evaluation within 6 months (OR = 4.10; 95% CI = 2.35, 7.17). A combined intervention adherence outcome that measured adherence to HAV-HBV vaccination, HCV evaluation, or both strongly favored the intervention group (OR = 8.70; 95% CI = 5.56, 13.61). Conclusions. Hepatitis care coordination was efficacious in increasing adherence to HAV-HBV vaccination and HCV clinical evaluation among methadone patients.

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