A quantitative analysis of the development of the central nervous system in juvenile Aplysia californica.

D. Cash, Thomas Carew

Research output: Contribution to journalArticle

Abstract

The marine mollusc Aplysia californica has proved to be a useful preparation for analyzing the development of learning and memory on both behavioral and cellular levels. An important issue in this analysis concerns the anatomical substrate upon which learning is superimposed during development. As a first step in examining this question, in the present study we have determined the number of neurons in all the major central ganglia at each stage during juvenile development, a time when several forms of learning first emerge in Aplysia. We found that a large and highly nonlinear proliferation of neurons occurs during juvenile development, with the greatest increase in cell number occurring during a specific juvenile stage: Stage 12. The neuronal proliferation is system-wide, occurring in each of the central ganglia simultaneously, suggesting the action of a general developmental signal or trigger (perhaps a hormone). Accompanying the increase in neuron number in Stage 12 there is a large increase in neuropilar volume (150-fold), which significantly increases the opportunity for synaptic interactions late in juvenile development.

Original languageEnglish (US)
Pages (from-to)25-47
Number of pages23
JournalJournal of Neurobiology
Volume20
Issue number1
StatePublished - Jan 1989

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Aplysia
Central Nervous System
Learning
Neurons
Ganglia
Mollusca
Cell Count
Hormones

ASJC Scopus subject areas

  • Neuroscience(all)

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A quantitative analysis of the development of the central nervous system in juvenile Aplysia californica. / Cash, D.; Carew, Thomas.

In: Journal of Neurobiology, Vol. 20, No. 1, 01.1989, p. 25-47.

Research output: Contribution to journalArticle

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