A principled method to identify individual differences and behavioral shifts in signaled active avoidance

Angelos Miltiadis Krypotos, Justin M. Moscarello, Robert M. Sears, Joseph Ledoux, Isaac Galatzer-Levy

Research output: Contribution to journalArticle

Abstract

Signaled active avoidance (SigAA) is the key experimental procedure for studying the acquisition of instrumental responses toward conditioned threat cues. Traditional analytic approaches (e.g., general linear model) often obfuscate important individual differences, although individual differences in learned responses characterize both animal and human learning data. However, individual differences models (e.g., latent growth curve modeling) typically require large samples and onerous computational methods. Here, we present an analytic methodology that enables the detection of individual differences in SigAA performance at a high accuracy, even when a single animal is included in the data set (i.e., n = 1 level). We further show an online software that enables the easy application of our method to any SigAA data set.

Original languageEnglish (US)
Pages (from-to)564-568
Number of pages5
JournalLearning & memory (Cold Spring Harbor, N.Y.)
Volume25
Issue number11
DOIs
StatePublished - Nov 1 2018

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Individuality
Cues
Linear Models
Software
Learning
Growth
Datasets

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

A principled method to identify individual differences and behavioral shifts in signaled active avoidance. / Krypotos, Angelos Miltiadis; Moscarello, Justin M.; Sears, Robert M.; Ledoux, Joseph; Galatzer-Levy, Isaac.

In: Learning & memory (Cold Spring Harbor, N.Y.), Vol. 25, No. 11, 01.11.2018, p. 564-568.

Research output: Contribution to journalArticle

Krypotos, Angelos Miltiadis ; Moscarello, Justin M. ; Sears, Robert M. ; Ledoux, Joseph ; Galatzer-Levy, Isaac. / A principled method to identify individual differences and behavioral shifts in signaled active avoidance. In: Learning & memory (Cold Spring Harbor, N.Y.). 2018 ; Vol. 25, No. 11. pp. 564-568.
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