A population-based prospective study of energy-providing nutrients in relation to all-cause cancer mortality and cancers of digestive organs mortality

Maria Argos, Stephanie Melkonian, Faruque Parvez, Muhammad Rakibuz-Zaman, Alauddin Ahmed, Yu Chen, Habibul Ahsan

Research output: Contribution to journalArticle

Abstract

The effect of dietary composition on mortality in low-income countries is largely unknown. We evaluated whether percentages of dietary energy derived from protein, fat and carbohydrates were associated with all-cause and cancer mortalities in a Bangladeshi population. Data from a prospective population-based cohort study of 17,244 men and women were used. Percentages of dietary energy derived from protein, fat and carbohydrates, assessed using a validated food-frequency questionnaire at baseline, were analyzed in relation to mortality over an average of 9 years (155,126 person-years) of follow-up. Cox proportional hazards regression models were used to estimate hazard ratios for all cause, all cancer and cancers of the digestive organs mortalities. Percentage of dietary energy from protein appeared to be significantly associated with cancer mortality. Fully adjusted hazard ratios for cancer mortality in increasing tertiles of percentage of dietary energy from protein were 1.0 (reference), 1.21 (0.73, 2.00) and 1.84 (1.08, 3.15) (p for trend = 0.023). These associations were much stronger for deaths from cancers of the digestive organs with fully adjusted hazard ratios in increasing tertiles of percentage of dietary energy from protein being 1.0 (reference), 2.25 (0.91, 5.59) and 4.85 (1.88, 12.51) (p for trend = 0.001). No significant associations in relation to cancer-related mortality were observed for percentage of dietary energy from fat. Novel findings from this prospective study show protein is an important risk factor or proxy to an important risk factor for cancer mortality especially from digestive organ cancers in Bangladesh.

Original languageEnglish (US)
Pages (from-to)2422-2428
Number of pages7
JournalInternational Journal of Cancer
Volume133
Issue number10
DOIs
StatePublished - Nov 15 2013

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Prospective Studies
Food
Mortality
Population
Neoplasms
Dietary Proteins
Fats
Carbohydrates
Proteins
Bangladesh
Dietary Fats
Proxy
Proportional Hazards Models
Cohort Studies

Keywords

  • Bangladesh
  • cancer mortality
  • diet
  • prospective study

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

A population-based prospective study of energy-providing nutrients in relation to all-cause cancer mortality and cancers of digestive organs mortality. / Argos, Maria; Melkonian, Stephanie; Parvez, Faruque; Rakibuz-Zaman, Muhammad; Ahmed, Alauddin; Chen, Yu; Ahsan, Habibul.

In: International Journal of Cancer, Vol. 133, No. 10, 15.11.2013, p. 2422-2428.

Research output: Contribution to journalArticle

Argos, Maria ; Melkonian, Stephanie ; Parvez, Faruque ; Rakibuz-Zaman, Muhammad ; Ahmed, Alauddin ; Chen, Yu ; Ahsan, Habibul. / A population-based prospective study of energy-providing nutrients in relation to all-cause cancer mortality and cancers of digestive organs mortality. In: International Journal of Cancer. 2013 ; Vol. 133, No. 10. pp. 2422-2428.
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