A photoswitchable neurotransmitter analogue bound to its receptor

Alwin Reiter, Arne Skerra, Dirk Trauner, André Schiefner

Research output: Contribution to journalArticle

Abstract

Incorporation of the azobenzene derivative gluazo, a synthetic photochromic ligand, into a kainate receptor allows for the optical control of neuronal activity. The crystal structure of gluazo bound to a dimeric GluK2 ligand-binding domain reveals one monomer in a closed conformation, occupied by gluazo, and the other in an open conformation, with a bound buffer molecule. The glutamate group of gluazo interacts like the natural glutamate ligand, while its trans-azobenzene moiety protrudes into a tunnel. This elongated cavity presumably cannot accommodate a cis-azobenzene, which explains the reversible activation of the receptor upon photoisomerization.

Original languageEnglish (US)
Pages (from-to)8972-8974
Number of pages3
JournalBiochemistry
Volume52
Issue number50
DOIs
StatePublished - Dec 17 2013

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Neurotransmitter Agents
Ligands
Conformations
Glutamic Acid
Kainic Acid Receptors
Photoisomerization
Tunnels
Buffers
Monomers
Crystal structure
Chemical activation
Derivatives
Molecules
azobenzene

ASJC Scopus subject areas

  • Biochemistry

Cite this

Reiter, A., Skerra, A., Trauner, D., & Schiefner, A. (2013). A photoswitchable neurotransmitter analogue bound to its receptor. Biochemistry, 52(50), 8972-8974. https://doi.org/10.1021/bi4014402

A photoswitchable neurotransmitter analogue bound to its receptor. / Reiter, Alwin; Skerra, Arne; Trauner, Dirk; Schiefner, André.

In: Biochemistry, Vol. 52, No. 50, 17.12.2013, p. 8972-8974.

Research output: Contribution to journalArticle

Reiter, A, Skerra, A, Trauner, D & Schiefner, A 2013, 'A photoswitchable neurotransmitter analogue bound to its receptor', Biochemistry, vol. 52, no. 50, pp. 8972-8974. https://doi.org/10.1021/bi4014402
Reiter A, Skerra A, Trauner D, Schiefner A. A photoswitchable neurotransmitter analogue bound to its receptor. Biochemistry. 2013 Dec 17;52(50):8972-8974. https://doi.org/10.1021/bi4014402
Reiter, Alwin ; Skerra, Arne ; Trauner, Dirk ; Schiefner, André. / A photoswitchable neurotransmitter analogue bound to its receptor. In: Biochemistry. 2013 ; Vol. 52, No. 50. pp. 8972-8974.
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