A Philosophical Perspective on Evolutionary Systems Biology

M. A. O'Malley, O. S. Soyer, M. L. Siegal

Research output: Contribution to journalArticle

Abstract

Evolutionary systems biology (ESB) is an emerging hybrid approach that integrates methods, models, and data from evolutionary and systems biology. Drawing on themes that arose at a cross-disciplinary meeting on ESB in 2013, we discuss in detail some of the explanatory friction that arises in the interaction between evolutionary and systems biology. These tensions appear because of different modeling approaches, diverse explanatory aims and strategies, and divergent views about the scope of the evolutionary synthesis. We locate these discussions in the context of long-running philosophical deliberations on explanation, modeling, and theoretical synthesis. We show how many of the issues central to ESB's progress can be understood as general philosophical problems. The benefits of addressing these philosophical issues feed back into philosophy too, because ESB provides excellent examples of scientific practice for the development of philosophy of science and philosophy of biology.
Original languageUndefined
Pages (from-to)6-17
Number of pages12
Journal Biological Theory
Volume10
DOIs
StatePublished - 2015

Cite this

A Philosophical Perspective on Evolutionary Systems Biology. / O'Malley, M. A.; Soyer, O. S.; Siegal, M. L.

In: Biological Theory, Vol. 10, 2015, p. 6-17.

Research output: Contribution to journalArticle

O'Malley, M. A. ; Soyer, O. S. ; Siegal, M. L. / A Philosophical Perspective on Evolutionary Systems Biology. In: Biological Theory. 2015 ; Vol. 10. pp. 6-17.
@article{5615ba2036104e83acdef04113530a62,
title = "A Philosophical Perspective on Evolutionary Systems Biology",
abstract = "Evolutionary systems biology (ESB) is an emerging hybrid approach that integrates methods, models, and data from evolutionary and systems biology. Drawing on themes that arose at a cross-disciplinary meeting on ESB in 2013, we discuss in detail some of the explanatory friction that arises in the interaction between evolutionary and systems biology. These tensions appear because of different modeling approaches, diverse explanatory aims and strategies, and divergent views about the scope of the evolutionary synthesis. We locate these discussions in the context of long-running philosophical deliberations on explanation, modeling, and theoretical synthesis. We show how many of the issues central to ESB's progress can be understood as general philosophical problems. The benefits of addressing these philosophical issues feed back into philosophy too, because ESB provides excellent examples of scientific practice for the development of philosophy of science and philosophy of biology.",
author = "O'Malley, {M. A.} and Soyer, {O. S.} and Siegal, {M. L.}",
note = "O'Malley, Maureen A Soyer, Orkun S Siegal, Mark L R01 GM086673/GM/NIGMS NIH HHS/United States R01 GM097415/GM/NIGMS NIH HHS/United States Journal article Biol Theory. 2015 Mar 1;10:6-17.",
year = "2015",
doi = "10.1007/s13752-015-0202-6",
language = "Undefined",
volume = "10",
pages = "6--17",
journal = "Biological Theory",
issn = "1555-5542",

}

TY - JOUR

T1 - A Philosophical Perspective on Evolutionary Systems Biology

AU - O'Malley, M. A.

AU - Soyer, O. S.

AU - Siegal, M. L.

N1 - O'Malley, Maureen A Soyer, Orkun S Siegal, Mark L R01 GM086673/GM/NIGMS NIH HHS/United States R01 GM097415/GM/NIGMS NIH HHS/United States Journal article Biol Theory. 2015 Mar 1;10:6-17.

PY - 2015

Y1 - 2015

N2 - Evolutionary systems biology (ESB) is an emerging hybrid approach that integrates methods, models, and data from evolutionary and systems biology. Drawing on themes that arose at a cross-disciplinary meeting on ESB in 2013, we discuss in detail some of the explanatory friction that arises in the interaction between evolutionary and systems biology. These tensions appear because of different modeling approaches, diverse explanatory aims and strategies, and divergent views about the scope of the evolutionary synthesis. We locate these discussions in the context of long-running philosophical deliberations on explanation, modeling, and theoretical synthesis. We show how many of the issues central to ESB's progress can be understood as general philosophical problems. The benefits of addressing these philosophical issues feed back into philosophy too, because ESB provides excellent examples of scientific practice for the development of philosophy of science and philosophy of biology.

AB - Evolutionary systems biology (ESB) is an emerging hybrid approach that integrates methods, models, and data from evolutionary and systems biology. Drawing on themes that arose at a cross-disciplinary meeting on ESB in 2013, we discuss in detail some of the explanatory friction that arises in the interaction between evolutionary and systems biology. These tensions appear because of different modeling approaches, diverse explanatory aims and strategies, and divergent views about the scope of the evolutionary synthesis. We locate these discussions in the context of long-running philosophical deliberations on explanation, modeling, and theoretical synthesis. We show how many of the issues central to ESB's progress can be understood as general philosophical problems. The benefits of addressing these philosophical issues feed back into philosophy too, because ESB provides excellent examples of scientific practice for the development of philosophy of science and philosophy of biology.

U2 - 10.1007/s13752-015-0202-6

DO - 10.1007/s13752-015-0202-6

M3 - Article

VL - 10

SP - 6

EP - 17

JO - Biological Theory

JF - Biological Theory

SN - 1555-5542

ER -