A Penetrating Look at Stochasticity in Development

Robert J. Johnston, Claude Desplan

Research output: Contribution to journalArticle

Abstract

In recent work published in Nature, Raj et al. (2010) use single mRNA molecule quantification to show that variation in gene expression in Caenorhabditis elegans increases in mutants displaying incomplete penetrance. They find that a bimodal response is triggered when noisy expression of an upstream regulator crosses a critical threshold.

Original languageEnglish (US)
Pages (from-to)610-612
Number of pages3
JournalCell
Volume140
Issue number5
DOIs
StatePublished - Mar 5 2010

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Penetrance
Caenorhabditis elegans
Gene expression
Gene Expression
Messenger RNA
Molecules

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

A Penetrating Look at Stochasticity in Development. / Johnston, Robert J.; Desplan, Claude.

In: Cell, Vol. 140, No. 5, 05.03.2010, p. 610-612.

Research output: Contribution to journalArticle

Johnston, Robert J. ; Desplan, Claude. / A Penetrating Look at Stochasticity in Development. In: Cell. 2010 ; Vol. 140, No. 5. pp. 610-612.
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