A new heart for a new head in vertebrate cardiopharyngeal evolution

Rui Diogo, Robert G. Kelly, Lionel Christiaen, Michael Levine, Janine M. Ziermann, Julia L. Molnar, Drew M. Noden, Eldad Tzahor

Research output: Contribution to journalArticle

Abstract

It has been more than 30 years since the publication of the new head hypothesis, which proposed that the vertebrate head is an evolutionary novelty resulting from the emergence of neural crest and cranial placodes. Neural crest generates the skull and associated connective tissues, whereas placodes produce sensory organs. However, neither crest nor placodes produce head muscles, which are a crucial component of the complex vertebrate head. We discuss emerging evidence for a surprising link between the evolution of head muscles and chambered hearts-both systems arise from a common pool of mesoderm progenitor cells within the cardiopharyngeal field of vertebrate embryos. We consider the origin of this field in non-vertebrate chordates and its evolution in vertebrates.

Original languageEnglish (US)
Pages (from-to)466-473
Number of pages8
JournalNature
Volume520
Issue number7548
DOIs
StatePublished - Apr 23 2015

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Vertebrates
Head
Neural Crest
Chordata
Mesoderm
Skull
Connective Tissue
Publications
Myocardium
Stem Cells
Embryonic Structures
Muscles

ASJC Scopus subject areas

  • General

Cite this

Diogo, R., Kelly, R. G., Christiaen, L., Levine, M., Ziermann, J. M., Molnar, J. L., ... Tzahor, E. (2015). A new heart for a new head in vertebrate cardiopharyngeal evolution. Nature, 520(7548), 466-473. https://doi.org/10.1038/nature14435

A new heart for a new head in vertebrate cardiopharyngeal evolution. / Diogo, Rui; Kelly, Robert G.; Christiaen, Lionel; Levine, Michael; Ziermann, Janine M.; Molnar, Julia L.; Noden, Drew M.; Tzahor, Eldad.

In: Nature, Vol. 520, No. 7548, 23.04.2015, p. 466-473.

Research output: Contribution to journalArticle

Diogo, R, Kelly, RG, Christiaen, L, Levine, M, Ziermann, JM, Molnar, JL, Noden, DM & Tzahor, E 2015, 'A new heart for a new head in vertebrate cardiopharyngeal evolution', Nature, vol. 520, no. 7548, pp. 466-473. https://doi.org/10.1038/nature14435
Diogo R, Kelly RG, Christiaen L, Levine M, Ziermann JM, Molnar JL et al. A new heart for a new head in vertebrate cardiopharyngeal evolution. Nature. 2015 Apr 23;520(7548):466-473. https://doi.org/10.1038/nature14435
Diogo, Rui ; Kelly, Robert G. ; Christiaen, Lionel ; Levine, Michael ; Ziermann, Janine M. ; Molnar, Julia L. ; Noden, Drew M. ; Tzahor, Eldad. / A new heart for a new head in vertebrate cardiopharyngeal evolution. In: Nature. 2015 ; Vol. 520, No. 7548. pp. 466-473.
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