A neuromuscular platform to extract electrophysiological signals from lesioned nerves

A technical note

Michael R. Wells, Urmi Vaidya, John Ricci, Carl Christie

Research output: Contribution to journalArticle

Abstract

The volitional control of prosthetic devices could be greatly enhanced if the information formerly supplied by peripheral nerves to the amputated limb could be utilized. So that practical access to this information could be gained, a method was established to form a stable biological interface with fascicles of lesioned nerves. A small strip of an intact muscle was isolated in rats with the use of a silicone tube cuff electrode and innervated by the lesioned peroneal branch of the sciatic nerve. After 4 weeks survival, stimulation of the nerve fascicle produced reliable signals from the neuromuscular platform in the range of 0.5 to 2.0 mV. Histologically, myotubes remained intact and axons could be identified growing in and over the surfaces of the isolated muscle strips. These or similar interface techniques may supply electrophysiological signals of sufficient amplitude and reliability to provide peripheral nerve-based guidance information for prosthetic devices.

Original languageEnglish (US)
Pages (from-to)385-390
Number of pages6
JournalJournal of Rehabilitation Research and Development
Volume38
Issue number4
StatePublished - 2001

Fingerprint

Prosthetics
Peripheral Nerves
Muscle
Equipment and Supplies
Muscles
Access to Information
Skeletal Muscle Fibers
Silicones
Sciatic Nerve
Axons
Rats
Electrodes
Extremities

Keywords

  • Electrodes
  • Lesioned nerves
  • Motor signals
  • Prosthetic
  • Volitional guidance

ASJC Scopus subject areas

  • Engineering(all)
  • Rehabilitation
  • Health Professions(all)

Cite this

A neuromuscular platform to extract electrophysiological signals from lesioned nerves : A technical note. / Wells, Michael R.; Vaidya, Urmi; Ricci, John; Christie, Carl.

In: Journal of Rehabilitation Research and Development, Vol. 38, No. 4, 2001, p. 385-390.

Research output: Contribution to journalArticle

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