A Neural Signature of Divisive Normalization at the Level of Multisensory Integration in Primate Cortex

Tomokazu Ohshiro, Dora Angelaki, Gregory C. DeAngelis

Research output: Contribution to journalArticle

Abstract

Studies of multisensory integration by single neurons have traditionally emphasized empirical principles that describe nonlinear interactions between inputs from two sensory modalities. We previously proposed that many of these empirical principles could be explained by a divisive normalization mechanism operating in brain regions where multisensory integration occurs. This normalization model makes a critical diagnostic prediction: a non-preferred sensory input from one modality, which activates the neuron on its own, should suppress the response to a preferred input from another modality. We tested this prediction by recording from neurons in macaque area MSTd that integrate visual and vestibular cues regarding self-motion. We show that many MSTd neurons exhibit the diagnostic form of cross-modal suppression, whereas unisensory neurons in area MT do not. The normalization model also fits population responses better than a model based on subtractive inhibition. These findings provide strong support for a divisive normalization mechanism in multisensory integration.

Original languageEnglish (US)
Pages (from-to)399-411.e8
JournalNeuron
Volume95
Issue number2
DOIs
StatePublished - Jul 19 2017

Fingerprint

Primates
Neurons
Macaca
Cues
Brain
Population

Keywords

  • electrophysiology
  • extra-striate cortex
  • heading
  • macaque
  • multisensory integration
  • normalization
  • optic flow
  • self-motion
  • vestibular

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A Neural Signature of Divisive Normalization at the Level of Multisensory Integration in Primate Cortex. / Ohshiro, Tomokazu; Angelaki, Dora; DeAngelis, Gregory C.

In: Neuron, Vol. 95, No. 2, 19.07.2017, p. 399-411.e8.

Research output: Contribution to journalArticle

Ohshiro, Tomokazu ; Angelaki, Dora ; DeAngelis, Gregory C. / A Neural Signature of Divisive Normalization at the Level of Multisensory Integration in Primate Cortex. In: Neuron. 2017 ; Vol. 95, No. 2. pp. 399-411.e8.
@article{980a14f6588543fbb121cf88cbd9e56b,
title = "A Neural Signature of Divisive Normalization at the Level of Multisensory Integration in Primate Cortex",
abstract = "Studies of multisensory integration by single neurons have traditionally emphasized empirical principles that describe nonlinear interactions between inputs from two sensory modalities. We previously proposed that many of these empirical principles could be explained by a divisive normalization mechanism operating in brain regions where multisensory integration occurs. This normalization model makes a critical diagnostic prediction: a non-preferred sensory input from one modality, which activates the neuron on its own, should suppress the response to a preferred input from another modality. We tested this prediction by recording from neurons in macaque area MSTd that integrate visual and vestibular cues regarding self-motion. We show that many MSTd neurons exhibit the diagnostic form of cross-modal suppression, whereas unisensory neurons in area MT do not. The normalization model also fits population responses better than a model based on subtractive inhibition. These findings provide strong support for a divisive normalization mechanism in multisensory integration.",
keywords = "electrophysiology, extra-striate cortex, heading, macaque, multisensory integration, normalization, optic flow, self-motion, vestibular",
author = "Tomokazu Ohshiro and Dora Angelaki and DeAngelis, {Gregory C.}",
year = "2017",
month = "7",
day = "19",
doi = "10.1016/j.neuron.2017.06.043",
language = "English (US)",
volume = "95",
pages = "399--411.e8",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",

}

TY - JOUR

T1 - A Neural Signature of Divisive Normalization at the Level of Multisensory Integration in Primate Cortex

AU - Ohshiro, Tomokazu

AU - Angelaki, Dora

AU - DeAngelis, Gregory C.

PY - 2017/7/19

Y1 - 2017/7/19

N2 - Studies of multisensory integration by single neurons have traditionally emphasized empirical principles that describe nonlinear interactions between inputs from two sensory modalities. We previously proposed that many of these empirical principles could be explained by a divisive normalization mechanism operating in brain regions where multisensory integration occurs. This normalization model makes a critical diagnostic prediction: a non-preferred sensory input from one modality, which activates the neuron on its own, should suppress the response to a preferred input from another modality. We tested this prediction by recording from neurons in macaque area MSTd that integrate visual and vestibular cues regarding self-motion. We show that many MSTd neurons exhibit the diagnostic form of cross-modal suppression, whereas unisensory neurons in area MT do not. The normalization model also fits population responses better than a model based on subtractive inhibition. These findings provide strong support for a divisive normalization mechanism in multisensory integration.

AB - Studies of multisensory integration by single neurons have traditionally emphasized empirical principles that describe nonlinear interactions between inputs from two sensory modalities. We previously proposed that many of these empirical principles could be explained by a divisive normalization mechanism operating in brain regions where multisensory integration occurs. This normalization model makes a critical diagnostic prediction: a non-preferred sensory input from one modality, which activates the neuron on its own, should suppress the response to a preferred input from another modality. We tested this prediction by recording from neurons in macaque area MSTd that integrate visual and vestibular cues regarding self-motion. We show that many MSTd neurons exhibit the diagnostic form of cross-modal suppression, whereas unisensory neurons in area MT do not. The normalization model also fits population responses better than a model based on subtractive inhibition. These findings provide strong support for a divisive normalization mechanism in multisensory integration.

KW - electrophysiology

KW - extra-striate cortex

KW - heading

KW - macaque

KW - multisensory integration

KW - normalization

KW - optic flow

KW - self-motion

KW - vestibular

UR - http://www.scopus.com/inward/record.url?scp=85023742642&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85023742642&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2017.06.043

DO - 10.1016/j.neuron.2017.06.043

M3 - Article

VL - 95

SP - 399-411.e8

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 2

ER -