A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain

Jessica E. Kleinbart, Amy L. Orsborn, John S. Choi, Charles Wang, Shaoyu Qiao, Jonathan Viventi, Bijan Pesaran

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Neural circuitry can be investigated and manipulated using a variety of techniques, including electrical and optical recording and stimulation. At present, most neural interfaces are designed to accommodate a single mode of neural recording and/or manipulation, which limits the amount of data that can be extracted from a single population of neurons. To overcome these technical limitations, we developed a chronic, multi-scale, multi-modal chamber-based neural implant for use in non-human primates that accommodates electrophysiological recording and stimulation, optical manipulation, and wide-field imaging. We present key design features of the system and mechanical validation. We also present sample data from two non-human primate subjects to validate the efficacy of the design in vivo.

Original languageEnglish (US)
Title of host publication40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages3362-3365
Number of pages4
Volume2018-July
ISBN (Electronic)9781538636466
DOIs
StatePublished - Oct 26 2018
Event40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 - Honolulu, United States
Duration: Jul 18 2018Jul 21 2018

Other

Other40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018
CountryUnited States
CityHonolulu
Period7/18/187/21/18

Fingerprint

Primates
Brain
Optical recording
Neurons
Imaging techniques
Population

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Kleinbart, J. E., Orsborn, A. L., Choi, J. S., Wang, C., Qiao, S., Viventi, J., & Pesaran, B. (2018). A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018 (Vol. 2018-July, pp. 3362-3365). [8512993] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2018.8512993

A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain. / Kleinbart, Jessica E.; Orsborn, Amy L.; Choi, John S.; Wang, Charles; Qiao, Shaoyu; Viventi, Jonathan; Pesaran, Bijan.

40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Vol. 2018-July Institute of Electrical and Electronics Engineers Inc., 2018. p. 3362-3365 8512993.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Kleinbart, JE, Orsborn, AL, Choi, JS, Wang, C, Qiao, S, Viventi, J & Pesaran, B 2018, A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain. in 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. vol. 2018-July, 8512993, Institute of Electrical and Electronics Engineers Inc., pp. 3362-3365, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018, Honolulu, United States, 7/18/18. https://doi.org/10.1109/EMBC.2018.8512993
Kleinbart JE, Orsborn AL, Choi JS, Wang C, Qiao S, Viventi J et al. A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain. In 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Vol. 2018-July. Institute of Electrical and Electronics Engineers Inc. 2018. p. 3362-3365. 8512993 https://doi.org/10.1109/EMBC.2018.8512993
Kleinbart, Jessica E. ; Orsborn, Amy L. ; Choi, John S. ; Wang, Charles ; Qiao, Shaoyu ; Viventi, Jonathan ; Pesaran, Bijan. / A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain. 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Vol. 2018-July Institute of Electrical and Electronics Engineers Inc., 2018. pp. 3362-3365
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