A Large-Scale Circuit Mechanism for Hierarchical Dynamical Processing in the Primate Cortex

Rishidev Chaudhuri, Kenneth Knoblauch, Marie Alice Gariel, Henry Kennedy, Xiao-Jing Wang

Research output: Contribution to journalArticle

Abstract

We developed a large-scale dynamical model of the macaque neocortex, which is based on recently acquired directed- and weighted-connectivity data from tract-tracing experiments, and which incorporates heterogeneity across areas. A hierarchy of timescales naturally emerges from this system: sensory areas show brief, transient responses to input (appropriate for sensory processing), whereas association areas integrate inputs over time and exhibit persistent activity (suitable for decision-making and working memory). The model displays multiple temporal hierarchies, as evidenced by contrasting responses to visual versus somatosensory stimulation. Moreover, slower prefrontal and temporal areas have a disproportionate impact on global brain dynamics. These findings establish a circuit mechanism for "temporal receptive windows" that are progressively enlarged along the cortical hierarchy, suggest an extension of time integration in decision making from local to large circuits, and should prompt a re-evaluation of the analysis of functional connectivity (measured by fMRI or electroencephalography/magnetoencephalography) by taking into account inter-areal heterogeneity. Chaudhuri et al. report a large-scale model of the macaque cortex incorporating quantitative anatomical data and inter-areal heterogeneity. This model gives rise to a hierarchy of timescales and suggests a revision of functional connectivity analysis of global brain dynamics.

Original languageEnglish (US)
Pages (from-to)419-431
Number of pages13
JournalNeuron
Volume88
Issue number2
DOIs
StatePublished - Oct 21 2015

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Primates
Macaca
Decision Making
Magnetoencephalography
Neocortex
Brain
Short-Term Memory
Electroencephalography
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A Large-Scale Circuit Mechanism for Hierarchical Dynamical Processing in the Primate Cortex. / Chaudhuri, Rishidev; Knoblauch, Kenneth; Gariel, Marie Alice; Kennedy, Henry; Wang, Xiao-Jing.

In: Neuron, Vol. 88, No. 2, 21.10.2015, p. 419-431.

Research output: Contribution to journalArticle

Chaudhuri, Rishidev ; Knoblauch, Kenneth ; Gariel, Marie Alice ; Kennedy, Henry ; Wang, Xiao-Jing. / A Large-Scale Circuit Mechanism for Hierarchical Dynamical Processing in the Primate Cortex. In: Neuron. 2015 ; Vol. 88, No. 2. pp. 419-431.
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