A histological study of non-ceramic hydroxyapatite as a bone graft substitute material in the vertical bone augmentation of the posterior mandible using an interpositional inlay technique

A split mouth evaluation

Karen Bechara, Alexandre M. Dottore, Paulo Y. Kawakami, Sergio A. Gehrke, Paulo Coelho, Adriano Piattelli, Giovanna Iezzi, Jamil Awad Shibli

Research output: Contribution to journalArticle

Abstract

The aim of this study was to compare the influence of graft material (non-ceramic hydroxyapatite versus autologous bone) on bone behaviour and perform a resonance frequency analysis of implants placed in augmented sites to evaluate stability. For this study, 11 patients with bilateral edentulous areas in the mandibular posterior region were selected. Alveolar augmentation osteotomies were bilaterally (split mouth design) performed. In one hemiarch, the space generated by the osteotomy was grafted with an interpositional intra-oral autologous bone graft (control group). In the other hemiarch, the space generated by the osteotomy was grafted with an interpositional non-ceramic hydroxyapatite (ncHA) (test group). The groups were randomized. After 6 months of healing, a bone sample was retrieved from each side for histological evaluation using a trephine drill that was 2-mm in internal diameter. The implant stability quotient (ISQ) was measured by the resonance frequency immediately following implant placement at baseline and after 6 months of follow-up. Good incorporation of the graft was observed in both groups; however, in the test group, a residual-grafted material was observed. Bone density and marrow spaces were similar between groups. Correlations between the ISQ values and the histometric variables were not observed (. p>. 0.05). The results of this trial suggest that both intra-oral autologous bone and ncHA may be elected as interpositional grafting materials to vertically augment posterior atrophic mandibles.

Original languageEnglish (US)
Article number50972
Pages (from-to)1-7
Number of pages7
JournalAnnals of Anatomy
Volume202
DOIs
StatePublished - Nov 1 2015

Fingerprint

Bone Substitutes
Inlays
Durapatite
Mandible
Mouth
Osteotomy
Transplants
Bone and Bones
Bone Density
Bone Marrow
Control Groups

Keywords

  • Bone graft
  • Inlay bone grafts
  • Non-ceramic hydroxyapatite
  • Posterior mandible graft
  • Resonance frequency analysis

ASJC Scopus subject areas

  • Anatomy
  • Developmental Biology

Cite this

A histological study of non-ceramic hydroxyapatite as a bone graft substitute material in the vertical bone augmentation of the posterior mandible using an interpositional inlay technique : A split mouth evaluation. / Bechara, Karen; Dottore, Alexandre M.; Kawakami, Paulo Y.; Gehrke, Sergio A.; Coelho, Paulo; Piattelli, Adriano; Iezzi, Giovanna; Shibli, Jamil Awad.

In: Annals of Anatomy, Vol. 202, 50972, 01.11.2015, p. 1-7.

Research output: Contribution to journalArticle

Bechara, Karen ; Dottore, Alexandre M. ; Kawakami, Paulo Y. ; Gehrke, Sergio A. ; Coelho, Paulo ; Piattelli, Adriano ; Iezzi, Giovanna ; Shibli, Jamil Awad. / A histological study of non-ceramic hydroxyapatite as a bone graft substitute material in the vertical bone augmentation of the posterior mandible using an interpositional inlay technique : A split mouth evaluation. In: Annals of Anatomy. 2015 ; Vol. 202. pp. 1-7.
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