A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan amazighs

Youssef Idaghdhour, John D. Storey, Sami J. Jadallah, Greg Gibson

Research output: Contribution to journalArticle

Abstract

The different environments that humans experience are likely to impact physiology and disease susceptibility. In order to estimate the magnitude of the impact of environment on transcript abundance, we examined gene expression in peripheral blood leukocyte samples from 46 desert nomadic, mountain agrarian and coastal urban Moroccan Amazigh individuals. Despite great expression heterogeneity in humans, as much as one third of the leukocyte transcriptome was found to be associated with differences among regions. Genome-wide polymorphism analysis indicates that genetic differentiation in the total sample is limited and is unlikely to explain the expression divergence. Methylation profiling of 1,505 CpG sites suggests limited contribution of methylation to the observed differences in gene expression. Genetic network analysis further implies that specific aspects of immune function are strongly affected by regional factors and may influence susceptibility to respiratory and inflammatory disease. Our results show a strong genome-wide gene expression signature of regional population differences that presumably include lifestyle, geography, and biotic factors, implying that these can play at least as great a role as genetic divergence in modulating gene expression variation in humans.

Original languageEnglish (US)
Article numbere1000052
JournalPLoS Genetics
Volume4
Issue number4
DOIs
StatePublished - Apr 1 2008

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Geography
geography
Transcriptome
gene expression
leukocytes
Leukocytes
genome
Genome
Gene Expression
Methylation
methylation
divergence
Disease Susceptibility
genetic variation
Life Style
biotic factor
network analysis
lifestyle
transcriptome
genetic differentiation

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research

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A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan amazighs. / Idaghdhour, Youssef; Storey, John D.; Jadallah, Sami J.; Gibson, Greg.

In: PLoS Genetics, Vol. 4, No. 4, e1000052, 01.04.2008.

Research output: Contribution to journalArticle

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