A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan amazighs

Youssef Idaghdhour, John D. Storey, Sami J. Jadallah, Greg Gibson

    Research output: Contribution to journalArticle

    Abstract

    The different environments that humans experience are likely to impact physiology and disease susceptibility. In order to estimate the magnitude of the impact of environment on transcript abundance, we examined gene expression in peripheral blood leukocyte samples from 46 desert nomadic, mountain agrarian and coastal urban Moroccan Amazigh individuals. Despite great expression heterogeneity in humans, as much as one third of the leukocyte transcriptome was found to be associated with differences among regions. Genome-wide polymorphism analysis indicates that genetic differentiation in the total sample is limited and is unlikely to explain the expression divergence. Methylation profiling of 1,505 CpG sites suggests limited contribution of methylation to the observed differences in gene expression. Genetic network analysis further implies that specific aspects of immune function are strongly affected by regional factors and may influence susceptibility to respiratory and inflammatory disease. Our results show a strong genome-wide gene expression signature of regional population differences that presumably include lifestyle, geography, and biotic factors, implying that these can play at least as great a role as genetic divergence in modulating gene expression variation in humans.

    Original languageEnglish (US)
    Article numbere1000052
    JournalPLoS Genetics
    Volume4
    Issue number4
    DOIs
    StatePublished - Apr 1 2008

    Fingerprint

    Geography
    geography
    Transcriptome
    gene expression
    leukocytes
    Leukocytes
    genome
    Genome
    Gene Expression
    Methylation
    methylation
    divergence
    Disease Susceptibility
    genetic variation
    Life Style
    biotic factor
    network analysis
    lifestyle
    transcriptome
    genetic differentiation

    ASJC Scopus subject areas

    • Ecology, Evolution, Behavior and Systematics
    • Molecular Biology
    • Genetics
    • Genetics(clinical)
    • Cancer Research

    Cite this

    A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan amazighs. / Idaghdhour, Youssef; Storey, John D.; Jadallah, Sami J.; Gibson, Greg.

    In: PLoS Genetics, Vol. 4, No. 4, e1000052, 01.04.2008.

    Research output: Contribution to journalArticle

    Idaghdhour, Youssef ; Storey, John D. ; Jadallah, Sami J. ; Gibson, Greg. / A genome-wide gene expression signature of environmental geography in leukocytes of Moroccan amazighs. In: PLoS Genetics. 2008 ; Vol. 4, No. 4.
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