A few disconnected notes related to Levinthal paradox

A. Grosberg

    Research output: Contribution to journalArticle

    Abstract

    We estimate that the longest protein chain capable of exhaustive sampling of all its conformations within a millisecond is shorter than 15 residues. This reinforces the understanding of Levinthal paradox which emerged in the last decade, namely, that cooperative (all-or-none) character of folding and unfolding transition is indicative of the sequences selected, such that reliable folding does not require exhaustive conformation sampling. The opinion is formulated that the discussions of Levinthal paradox should now fly to the new spheres.

    Original languageEnglish (US)
    Pages (from-to)317-321
    Number of pages5
    JournalJournal of Biomolecular Structure and Dynamics
    Volume20
    Issue number3
    StatePublished - Dec 2002

    Fingerprint

    Proteins

    ASJC Scopus subject areas

    • Molecular Biology
    • Structural Biology

    Cite this

    A few disconnected notes related to Levinthal paradox. / Grosberg, A.

    In: Journal of Biomolecular Structure and Dynamics, Vol. 20, No. 3, 12.2002, p. 317-321.

    Research output: Contribution to journalArticle

    @article{cf5b129aab1b4027993cb0f291b3889a,
    title = "A few disconnected notes related to Levinthal paradox",
    abstract = "We estimate that the longest protein chain capable of exhaustive sampling of all its conformations within a millisecond is shorter than 15 residues. This reinforces the understanding of Levinthal paradox which emerged in the last decade, namely, that cooperative (all-or-none) character of folding and unfolding transition is indicative of the sequences selected, such that reliable folding does not require exhaustive conformation sampling. The opinion is formulated that the discussions of Levinthal paradox should now fly to the new spheres.",
    author = "A. Grosberg",
    year = "2002",
    month = "12",
    language = "English (US)",
    volume = "20",
    pages = "317--321",
    journal = "Journal of Biomolecular Structure and Dynamics",
    issn = "0739-1102",
    publisher = "Adenine Press",
    number = "3",

    }

    TY - JOUR

    T1 - A few disconnected notes related to Levinthal paradox

    AU - Grosberg, A.

    PY - 2002/12

    Y1 - 2002/12

    N2 - We estimate that the longest protein chain capable of exhaustive sampling of all its conformations within a millisecond is shorter than 15 residues. This reinforces the understanding of Levinthal paradox which emerged in the last decade, namely, that cooperative (all-or-none) character of folding and unfolding transition is indicative of the sequences selected, such that reliable folding does not require exhaustive conformation sampling. The opinion is formulated that the discussions of Levinthal paradox should now fly to the new spheres.

    AB - We estimate that the longest protein chain capable of exhaustive sampling of all its conformations within a millisecond is shorter than 15 residues. This reinforces the understanding of Levinthal paradox which emerged in the last decade, namely, that cooperative (all-or-none) character of folding and unfolding transition is indicative of the sequences selected, such that reliable folding does not require exhaustive conformation sampling. The opinion is formulated that the discussions of Levinthal paradox should now fly to the new spheres.

    UR - http://www.scopus.com/inward/record.url?scp=0036918484&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0036918484&partnerID=8YFLogxK

    M3 - Article

    VL - 20

    SP - 317

    EP - 321

    JO - Journal of Biomolecular Structure and Dynamics

    JF - Journal of Biomolecular Structure and Dynamics

    SN - 0739-1102

    IS - 3

    ER -