A double dissociation in the affective modulation of startle in humans: Effects of unilateral temporal lobectomy

E. Sumie Funayama, Christian Grillon, Michael Davis, Elizabeth Phelps

Research output: Contribution to journalArticle

Abstract

In the present study we report a double dissociation between right and left medial temporal lobe damage in the modulation of fear responses to different types of stimuli. We found that right unilateral temporal lobectomy (RTL) patients, in contrast to control subjects and left temporal lobectomy (LTL) patients, failed to show potentiated startle while viewing negative pictures. However, the opposite pattern of impairment was observed during a stimulus that patients had been told signaled the possibility of shock. Control subjects and RTL patients showed potentiated startle while LTL patients failed to show potentiated startle. We hypothesize that the right medial temporal lobe modulates fear responses while viewing emotional pictures, which involves exposure to (emotional) visual information and is consistent with the emotional processing traditionally ascribed to the right hemisphere. In contrast, the left medial temporal lobe modulates fear responses when those responses are the result of a linguistic/cognitive representation acquired through language, which, like other verbally mediated material, generally involves the left hemisphere. Additional evidence from case studies suggests that, within the medial temporal lobe, the amygdala is responsible for this modulation.

Original languageEnglish (US)
Pages (from-to)721-729
Number of pages9
JournalJournal of Cognitive Neuroscience
Volume13
Issue number6
DOIs
StatePublished - Aug 15 2001

Fingerprint

Temporal Lobe
Fear
Linguistics
Amygdala
Shock
Language

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

Cite this

A double dissociation in the affective modulation of startle in humans : Effects of unilateral temporal lobectomy. / Funayama, E. Sumie; Grillon, Christian; Davis, Michael; Phelps, Elizabeth.

In: Journal of Cognitive Neuroscience, Vol. 13, No. 6, 15.08.2001, p. 721-729.

Research output: Contribution to journalArticle

@article{5f11cf5adc864ee6a3462a409febe6c1,
title = "A double dissociation in the affective modulation of startle in humans: Effects of unilateral temporal lobectomy",
abstract = "In the present study we report a double dissociation between right and left medial temporal lobe damage in the modulation of fear responses to different types of stimuli. We found that right unilateral temporal lobectomy (RTL) patients, in contrast to control subjects and left temporal lobectomy (LTL) patients, failed to show potentiated startle while viewing negative pictures. However, the opposite pattern of impairment was observed during a stimulus that patients had been told signaled the possibility of shock. Control subjects and RTL patients showed potentiated startle while LTL patients failed to show potentiated startle. We hypothesize that the right medial temporal lobe modulates fear responses while viewing emotional pictures, which involves exposure to (emotional) visual information and is consistent with the emotional processing traditionally ascribed to the right hemisphere. In contrast, the left medial temporal lobe modulates fear responses when those responses are the result of a linguistic/cognitive representation acquired through language, which, like other verbally mediated material, generally involves the left hemisphere. Additional evidence from case studies suggests that, within the medial temporal lobe, the amygdala is responsible for this modulation.",
author = "Funayama, {E. Sumie} and Christian Grillon and Michael Davis and Elizabeth Phelps",
year = "2001",
month = "8",
day = "15",
doi = "10.1162/08989290152541395",
language = "English (US)",
volume = "13",
pages = "721--729",
journal = "Journal of Cognitive Neuroscience",
issn = "0898-929X",
publisher = "MIT Press Journals",
number = "6",

}

TY - JOUR

T1 - A double dissociation in the affective modulation of startle in humans

T2 - Effects of unilateral temporal lobectomy

AU - Funayama, E. Sumie

AU - Grillon, Christian

AU - Davis, Michael

AU - Phelps, Elizabeth

PY - 2001/8/15

Y1 - 2001/8/15

N2 - In the present study we report a double dissociation between right and left medial temporal lobe damage in the modulation of fear responses to different types of stimuli. We found that right unilateral temporal lobectomy (RTL) patients, in contrast to control subjects and left temporal lobectomy (LTL) patients, failed to show potentiated startle while viewing negative pictures. However, the opposite pattern of impairment was observed during a stimulus that patients had been told signaled the possibility of shock. Control subjects and RTL patients showed potentiated startle while LTL patients failed to show potentiated startle. We hypothesize that the right medial temporal lobe modulates fear responses while viewing emotional pictures, which involves exposure to (emotional) visual information and is consistent with the emotional processing traditionally ascribed to the right hemisphere. In contrast, the left medial temporal lobe modulates fear responses when those responses are the result of a linguistic/cognitive representation acquired through language, which, like other verbally mediated material, generally involves the left hemisphere. Additional evidence from case studies suggests that, within the medial temporal lobe, the amygdala is responsible for this modulation.

AB - In the present study we report a double dissociation between right and left medial temporal lobe damage in the modulation of fear responses to different types of stimuli. We found that right unilateral temporal lobectomy (RTL) patients, in contrast to control subjects and left temporal lobectomy (LTL) patients, failed to show potentiated startle while viewing negative pictures. However, the opposite pattern of impairment was observed during a stimulus that patients had been told signaled the possibility of shock. Control subjects and RTL patients showed potentiated startle while LTL patients failed to show potentiated startle. We hypothesize that the right medial temporal lobe modulates fear responses while viewing emotional pictures, which involves exposure to (emotional) visual information and is consistent with the emotional processing traditionally ascribed to the right hemisphere. In contrast, the left medial temporal lobe modulates fear responses when those responses are the result of a linguistic/cognitive representation acquired through language, which, like other verbally mediated material, generally involves the left hemisphere. Additional evidence from case studies suggests that, within the medial temporal lobe, the amygdala is responsible for this modulation.

UR - http://www.scopus.com/inward/record.url?scp=0035880982&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035880982&partnerID=8YFLogxK

U2 - 10.1162/08989290152541395

DO - 10.1162/08989290152541395

M3 - Article

C2 - 11564317

AN - SCOPUS:0035880982

VL - 13

SP - 721

EP - 729

JO - Journal of Cognitive Neuroscience

JF - Journal of Cognitive Neuroscience

SN - 0898-929X

IS - 6

ER -