A diversity of localized timescales in network activity

Rishidev Chaudhuri, Alberto Bernacchia, Xiao Jing Wang

Research output: Contribution to journalArticle

Abstract

Neurons show diverse timescales, so that different parts of a network respond with disparate temporal dynamics. Such diversity is observed both when comparing timescales across brain areas and among cells within local populations; the underlying circuit mechanism remains unknown. We examine conditions under which spatially local connectivity can produce such diverse temporal behavior. In a linear network, timescales are segregated if the eigenvectors of the connectivity matrix are localized to different parts of the network. We develop a framework to predict the shapes of localized eigenvectors. Notably, local connectivity alone is insufficient for separate timescales. However, localization of timescales can be realized by heterogeneity in the connectivity profile, and we demonstrate two classes of network architecture that allow such localization. Our results suggest a framework to relate structural heterogeneity to functional diversity and, beyond neural dynamics, are generally applicable to the relationship between structure and dynamics in biological networks. DOI: http://dx.doi.org/10.7554/eLife.01239.001.

Original languageEnglish (US)
Pages (from-to)e01239
JournaleLife
Volume3
DOIs
StatePublished - 2014

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Eigenvalues and eigenfunctions
Linear networks
Network architecture
Neurons
Brain
Population
Networks (circuits)

Keywords

  • network dynamics
  • neural networks
  • timescales

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A diversity of localized timescales in network activity. / Chaudhuri, Rishidev; Bernacchia, Alberto; Wang, Xiao Jing.

In: eLife, Vol. 3, 2014, p. e01239.

Research output: Contribution to journalArticle

Chaudhuri, Rishidev ; Bernacchia, Alberto ; Wang, Xiao Jing. / A diversity of localized timescales in network activity. In: eLife. 2014 ; Vol. 3. pp. e01239.
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