A distributed network for social cognition enriched for oxytocin receptors

Mariela Mitre, Bianca J. Marlin, Jennifer K. Schiavo, Egzona Morina, Samantha E. Norden, Troy A. Hackett, Chiye Aoki, Moses V. Chao, Robert C. Froemke

Research output: Contribution to journalArticle

Abstract

Oxytocin is a neuropeptide important for social behaviors such as maternal care and parent–infant bonding. It is believed that oxytocin receptor signaling in the brain is critical for these behaviors, but it is unknown precisely when and where oxytocin receptors are expressed or which neural circuits are directly sensitive to oxytocin. To overcome this challenge, we generated specific antibodies to the mouse oxytocin receptor and examined receptor expression throughout the brain. We identified a distributed network of female mouse brain regions for maternal behaviors that are especially enriched for oxytocin receptors, including the piriform cortex, the left auditory cortex, and CA2 of the hippocampus. Electron microscopic analysis of the cerebral cortex revealed that oxytocin receptors were mainly expressed at synapses, as well as on axons and glial processes. Functionally, oxytocin transiently reduced synaptic inhibition in multiple brain regions and enabled long-term synaptic plasticity in the auditory cortex. Thus modulation of inhibition may be a general mechanism by which oxytocin can act throughout the brain to regulate parental behaviors and social cognition.

Original languageEnglish (US)
Pages (from-to)2517-2535
Number of pages19
JournalJournal of Neuroscience
Volume36
Issue number8
DOIs
StatePublished - Feb 24 2016

Fingerprint

Oxytocin Receptors
Social Support
Cognition
Oxytocin
Brain
Auditory Cortex
Maternal Behavior
Neuronal Plasticity
Social Behavior
Neuropeptides
Neuroglia
Cerebral Cortex
Synapses
Axons
Hippocampus
Mothers
Electrons
Antibodies

Keywords

  • Antibody
  • Auditory cortex
  • Development
  • Inhibition
  • Oxytocin
  • Synaptic plasticity

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mitre, M., Marlin, B. J., Schiavo, J. K., Morina, E., Norden, S. E., Hackett, T. A., ... Froemke, R. C. (2016). A distributed network for social cognition enriched for oxytocin receptors. Journal of Neuroscience, 36(8), 2517-2535. https://doi.org/10.1523/JNEUROSCI.2409-15.2016

A distributed network for social cognition enriched for oxytocin receptors. / Mitre, Mariela; Marlin, Bianca J.; Schiavo, Jennifer K.; Morina, Egzona; Norden, Samantha E.; Hackett, Troy A.; Aoki, Chiye; Chao, Moses V.; Froemke, Robert C.

In: Journal of Neuroscience, Vol. 36, No. 8, 24.02.2016, p. 2517-2535.

Research output: Contribution to journalArticle

Mitre, M, Marlin, BJ, Schiavo, JK, Morina, E, Norden, SE, Hackett, TA, Aoki, C, Chao, MV & Froemke, RC 2016, 'A distributed network for social cognition enriched for oxytocin receptors', Journal of Neuroscience, vol. 36, no. 8, pp. 2517-2535. https://doi.org/10.1523/JNEUROSCI.2409-15.2016
Mitre M, Marlin BJ, Schiavo JK, Morina E, Norden SE, Hackett TA et al. A distributed network for social cognition enriched for oxytocin receptors. Journal of Neuroscience. 2016 Feb 24;36(8):2517-2535. https://doi.org/10.1523/JNEUROSCI.2409-15.2016
Mitre, Mariela ; Marlin, Bianca J. ; Schiavo, Jennifer K. ; Morina, Egzona ; Norden, Samantha E. ; Hackett, Troy A. ; Aoki, Chiye ; Chao, Moses V. ; Froemke, Robert C. / A distributed network for social cognition enriched for oxytocin receptors. In: Journal of Neuroscience. 2016 ; Vol. 36, No. 8. pp. 2517-2535.
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