A disinhibitory circuit mediates motor integration in the somatosensory cortex

Soohyun Lee, Illya Kruglikov, Z. Josh Huang, Gordon Fishell, Bernardo Rudy

Research output: Contribution to journalArticle

Abstract

The influence of motor activity on sensory processing is crucial for perception and motor execution. However, the underlying circuits are not known. To unravel the circuit by which activity in the primary vibrissal motor cortex (vM1) modulates sensory processing in the primary somatosensory barrel cortex (S1), we used optogenetics to examine the long-range inputs from vM1 to the various neuronal elements in S1. We found that S1-projecting vM1 pyramidal neurons strongly recruited vasointestinal peptide (VIP)-expressing GABAergic interneurons, a subset of serotonin receptor-expressing interneurons. These VIP interneurons preferentially inhibited somatostatin-expressing interneurons, neurons that target the distal dendrites of pyramidal cells. Consistent with this vM1-mediated disinhibitory circuit, the activity of VIP interneurons in vivo increased and that of somatostatin interneurons decreased during whisking. These changes in firing rates during whisking depended on vM1 activity. Our results suggest previously unknown circuitry by which inputs from motor cortex influence sensory processing in sensory cortex.

Original languageEnglish (US)
Pages (from-to)1662-1670
Number of pages9
JournalNature Neuroscience
Volume16
Issue number11
DOIs
StatePublished - Nov 1 2013

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Somatosensory Cortex
Interneurons
Vasoactive Intestinal Peptide
Pyramidal Cells
Somatostatin
Optogenetics
Serotonin Receptors
Motor Cortex
Dendrites
Motor Activity
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

A disinhibitory circuit mediates motor integration in the somatosensory cortex. / Lee, Soohyun; Kruglikov, Illya; Huang, Z. Josh; Fishell, Gordon; Rudy, Bernardo.

In: Nature Neuroscience, Vol. 16, No. 11, 01.11.2013, p. 1662-1670.

Research output: Contribution to journalArticle

Lee, Soohyun ; Kruglikov, Illya ; Huang, Z. Josh ; Fishell, Gordon ; Rudy, Bernardo. / A disinhibitory circuit mediates motor integration in the somatosensory cortex. In: Nature Neuroscience. 2013 ; Vol. 16, No. 11. pp. 1662-1670.
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