A developmental cell-type switch in cortical interneurons leads to a selective defect in cortical oscillations

Naoki Takada, Hyun Jae Pi, Vitor H. Sousa, Jack Waters, Gordon Fishell, Adam Kepecs, Pavel Osten

Research output: Contribution to journalArticle

Abstract

The cellular diversity of interneurons in the neocortex is thought to reflect subtype-specific roles of cortical inhibition. Here we ask whether perturbations to two subtypes -parvalbumin-positive (PV+) and somatostatin-positive (SST+) interneurons -can be compensated for with respect to their contributions to cortical development. We use a genetic cell fate switch to delete both PV+ and SST+ interneurons selectively in cortical layers 2-4 without numerically changing the total interneuron population. This manipulation is compensated for at the level of synaptic currents and receptive fields (RFs) in the somatosensory cortex. By contrast, we identify a deficit in inhibitory synchronization in vitro and a large reduction in cortical gamma oscillations in vivo. This reveals that, while the roles of inhibition in establishing cortical inhibitory/excitatory balance and RFs can be subserved by multiple interneuron subtypes, gamma oscillations depend on cellular properties that cannot be compensated for -likely, the fast signalling properties of PV+ interneurons. & copy; 2014 Macmillan Publishers Limited. All rights reserved.

Original languageEnglish (US)
Article number5333
JournalNature Communications
Volume5
DOIs
StatePublished - Jan 1 2014

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Parvalbumins
Interneurons
Somatostatin
Synchronization
switches
Switches
Defects
oscillations
cortexes
defects
cells
manipulators
synchronism
perturbation
Somatosensory Cortex
Neocortex
Population

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

A developmental cell-type switch in cortical interneurons leads to a selective defect in cortical oscillations. / Takada, Naoki; Pi, Hyun Jae; Sousa, Vitor H.; Waters, Jack; Fishell, Gordon; Kepecs, Adam; Osten, Pavel.

In: Nature Communications, Vol. 5, 5333, 01.01.2014.

Research output: Contribution to journalArticle

Takada, Naoki ; Pi, Hyun Jae ; Sousa, Vitor H. ; Waters, Jack ; Fishell, Gordon ; Kepecs, Adam ; Osten, Pavel. / A developmental cell-type switch in cortical interneurons leads to a selective defect in cortical oscillations. In: Nature Communications. 2014 ; Vol. 5.
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