Abstract
The cellular diversity of interneurons in the neocortex is thought to reflect subtype-specific roles of cortical inhibition. Here we ask whether perturbations to two subtypes -parvalbumin-positive (PV+) and somatostatin-positive (SST+) interneurons -can be compensated for with respect to their contributions to cortical development. We use a genetic cell fate switch to delete both PV+ and SST+ interneurons selectively in cortical layers 2-4 without numerically changing the total interneuron population. This manipulation is compensated for at the level of synaptic currents and receptive fields (RFs) in the somatosensory cortex. By contrast, we identify a deficit in inhibitory synchronization in vitro and a large reduction in cortical gamma oscillations in vivo. This reveals that, while the roles of inhibition in establishing cortical inhibitory/excitatory balance and RFs can be subserved by multiple interneuron subtypes, gamma oscillations depend on cellular properties that cannot be compensated for -likely, the fast signalling properties of PV+ interneurons. & copy; 2014 Macmillan Publishers Limited. All rights reserved.
| Original language | English (US) |
|---|---|
| Article number | 5333 |
| Journal | Nature Communications |
| Volume | 5 |
| DOIs | |
| State | Published - Jan 1 2014 |
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ASJC Scopus subject areas
- Chemistry(all)
- Biochemistry, Genetics and Molecular Biology(all)
- Physics and Astronomy(all)
Cite this
A developmental cell-type switch in cortical interneurons leads to a selective defect in cortical oscillations. / Takada, Naoki; Pi, Hyun Jae; Sousa, Vitor H.; Waters, Jack; Fishell, Gordon; Kepecs, Adam; Osten, Pavel.
In: Nature Communications, Vol. 5, 5333, 01.01.2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A developmental cell-type switch in cortical interneurons leads to a selective defect in cortical oscillations
AU - Takada, Naoki
AU - Pi, Hyun Jae
AU - Sousa, Vitor H.
AU - Waters, Jack
AU - Fishell, Gordon
AU - Kepecs, Adam
AU - Osten, Pavel
PY - 2014/1/1
Y1 - 2014/1/1
N2 - The cellular diversity of interneurons in the neocortex is thought to reflect subtype-specific roles of cortical inhibition. Here we ask whether perturbations to two subtypes -parvalbumin-positive (PV+) and somatostatin-positive (SST+) interneurons -can be compensated for with respect to their contributions to cortical development. We use a genetic cell fate switch to delete both PV+ and SST+ interneurons selectively in cortical layers 2-4 without numerically changing the total interneuron population. This manipulation is compensated for at the level of synaptic currents and receptive fields (RFs) in the somatosensory cortex. By contrast, we identify a deficit in inhibitory synchronization in vitro and a large reduction in cortical gamma oscillations in vivo. This reveals that, while the roles of inhibition in establishing cortical inhibitory/excitatory balance and RFs can be subserved by multiple interneuron subtypes, gamma oscillations depend on cellular properties that cannot be compensated for -likely, the fast signalling properties of PV+ interneurons. & copy; 2014 Macmillan Publishers Limited. All rights reserved.
AB - The cellular diversity of interneurons in the neocortex is thought to reflect subtype-specific roles of cortical inhibition. Here we ask whether perturbations to two subtypes -parvalbumin-positive (PV+) and somatostatin-positive (SST+) interneurons -can be compensated for with respect to their contributions to cortical development. We use a genetic cell fate switch to delete both PV+ and SST+ interneurons selectively in cortical layers 2-4 without numerically changing the total interneuron population. This manipulation is compensated for at the level of synaptic currents and receptive fields (RFs) in the somatosensory cortex. By contrast, we identify a deficit in inhibitory synchronization in vitro and a large reduction in cortical gamma oscillations in vivo. This reveals that, while the roles of inhibition in establishing cortical inhibitory/excitatory balance and RFs can be subserved by multiple interneuron subtypes, gamma oscillations depend on cellular properties that cannot be compensated for -likely, the fast signalling properties of PV+ interneurons. & copy; 2014 Macmillan Publishers Limited. All rights reserved.
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U2 - 10.1038/ncomms6333
DO - 10.1038/ncomms6333
M3 - Article
C2 - 25354876
AN - SCOPUS:84923320685
VL - 5
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 5333
ER -