A cross-sectional study of water arsenic exposure and intellectual function in adolescence in Araihazar, Bangladesh

Gail A. Wasserman, Xinhua Liu, Faruque Parvez, Yu Chen, Pam Factor-Litvak, Nancy J. LoIacono, Diane Levy, Hasan Shahriar, Mohammed Nasir Uddin, Tariqul Islam, Angela Lomax, Roheeni Saxena, Elizabeth A. Gibson, Marianthi Anna Kioumourtzoglou, Olgica Balac, Tiffany Sanchez, Jennie K. Kline, David Santiago, Tyler Ellis, Alexander van GeenJoseph H. Graziano

Research output: Contribution to journalArticle

Abstract

Background: Exposure to inorganic arsenic (As) from drinking water is associated with modest deficits in intellectual function in young children; it is unclear whether deficits occur during adolescence, when key brain functions are more fully developed. Objectives: We sought to determine the degree to which As exposure is associated with adolescent intelligence, and the contributory roles of lead, cadmium, manganese and selenium. Methods: We recruited a cross-section of 726 14–16 year olds (mean age = 14.8 years) whose mothers are participants in the Bangladesh Health Effects of Arsenic Longitudinal Study (HEALS), and whose household well water As levels, which varied widely, were well characterized. Using a culturally modified version of the WISC-IV, we examined raw Full Scale scores, and Verbal Comprehension, Perceptual Reasoning, Working Memory and Processing Speed Indices. Blood levels of As (BAs), Mn, Pb, Cd and Se were assessed at the time of the visit, as was creatinine-adjusted urinary As (UAs/Cr). Results: Linear regression analyses revealed that BAs was significantly negatively associated with all WISC-IV scores except for Perceptual Reasoning. With UAs/Cr as the exposure variable, we observed significantly negative associations for all WISC-IV scores. Except for Se, blood levels of other metals, were also associated with lower WISC-IV scores. Controlling for covariates, doubling BAs, or UAs/Cr, was associated with a mean decrement (95% CI) of 3.3 (1.1, 5.5), or 3.0 (1.2, 4.5) points, respectively, in raw Full scale scores with a sample mean of 177.6 (SD = 36.8). Confirmatory analyses using Bayesian Kernel Machine Regression, which identifies important mixture members, supported these findings; the primary contributor of the mixture was BAs, followed by BCd. Conclusions: Our data indicate that the adverse consequences of As exposure on neurodevelopment observed in other cross-sectional studies of younger children are also apparent during adolescence. They also implicate Cd as a neurotoxic element that deserves more attention.

Original languageEnglish (US)
Pages (from-to)304-313
Number of pages10
JournalEnvironment International
Volume118
DOIs
StatePublished - Sep 1 2018

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adolescence
arsenic
water
blood
exposure
well water
selenium
brain
manganese
cadmium
cross section
drinking water
metal

Keywords

  • Adolescence
  • Arsenic exposure
  • Cognitive test scores
  • Intellectual function
  • Metal mixtures

ASJC Scopus subject areas

  • Environmental Science(all)

Cite this

A cross-sectional study of water arsenic exposure and intellectual function in adolescence in Araihazar, Bangladesh. / Wasserman, Gail A.; Liu, Xinhua; Parvez, Faruque; Chen, Yu; Factor-Litvak, Pam; LoIacono, Nancy J.; Levy, Diane; Shahriar, Hasan; Uddin, Mohammed Nasir; Islam, Tariqul; Lomax, Angela; Saxena, Roheeni; Gibson, Elizabeth A.; Kioumourtzoglou, Marianthi Anna; Balac, Olgica; Sanchez, Tiffany; Kline, Jennie K.; Santiago, David; Ellis, Tyler; van Geen, Alexander; Graziano, Joseph H.

In: Environment International, Vol. 118, 01.09.2018, p. 304-313.

Research output: Contribution to journalArticle

Wasserman, GA, Liu, X, Parvez, F, Chen, Y, Factor-Litvak, P, LoIacono, NJ, Levy, D, Shahriar, H, Uddin, MN, Islam, T, Lomax, A, Saxena, R, Gibson, EA, Kioumourtzoglou, MA, Balac, O, Sanchez, T, Kline, JK, Santiago, D, Ellis, T, van Geen, A & Graziano, JH 2018, 'A cross-sectional study of water arsenic exposure and intellectual function in adolescence in Araihazar, Bangladesh', Environment International, vol. 118, pp. 304-313. https://doi.org/10.1016/j.envint.2018.05.037
Wasserman, Gail A. ; Liu, Xinhua ; Parvez, Faruque ; Chen, Yu ; Factor-Litvak, Pam ; LoIacono, Nancy J. ; Levy, Diane ; Shahriar, Hasan ; Uddin, Mohammed Nasir ; Islam, Tariqul ; Lomax, Angela ; Saxena, Roheeni ; Gibson, Elizabeth A. ; Kioumourtzoglou, Marianthi Anna ; Balac, Olgica ; Sanchez, Tiffany ; Kline, Jennie K. ; Santiago, David ; Ellis, Tyler ; van Geen, Alexander ; Graziano, Joseph H. / A cross-sectional study of water arsenic exposure and intellectual function in adolescence in Araihazar, Bangladesh. In: Environment International. 2018 ; Vol. 118. pp. 304-313.
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abstract = "Background: Exposure to inorganic arsenic (As) from drinking water is associated with modest deficits in intellectual function in young children; it is unclear whether deficits occur during adolescence, when key brain functions are more fully developed. Objectives: We sought to determine the degree to which As exposure is associated with adolescent intelligence, and the contributory roles of lead, cadmium, manganese and selenium. Methods: We recruited a cross-section of 726 14–16 year olds (mean age = 14.8 years) whose mothers are participants in the Bangladesh Health Effects of Arsenic Longitudinal Study (HEALS), and whose household well water As levels, which varied widely, were well characterized. Using a culturally modified version of the WISC-IV, we examined raw Full Scale scores, and Verbal Comprehension, Perceptual Reasoning, Working Memory and Processing Speed Indices. Blood levels of As (BAs), Mn, Pb, Cd and Se were assessed at the time of the visit, as was creatinine-adjusted urinary As (UAs/Cr). Results: Linear regression analyses revealed that BAs was significantly negatively associated with all WISC-IV scores except for Perceptual Reasoning. With UAs/Cr as the exposure variable, we observed significantly negative associations for all WISC-IV scores. Except for Se, blood levels of other metals, were also associated with lower WISC-IV scores. Controlling for covariates, doubling BAs, or UAs/Cr, was associated with a mean decrement (95{\%} CI) of 3.3 (1.1, 5.5), or 3.0 (1.2, 4.5) points, respectively, in raw Full scale scores with a sample mean of 177.6 (SD = 36.8). Confirmatory analyses using Bayesian Kernel Machine Regression, which identifies important mixture members, supported these findings; the primary contributor of the mixture was BAs, followed by BCd. Conclusions: Our data indicate that the adverse consequences of As exposure on neurodevelopment observed in other cross-sectional studies of younger children are also apparent during adolescence. They also implicate Cd as a neurotoxic element that deserves more attention.",
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T1 - A cross-sectional study of water arsenic exposure and intellectual function in adolescence in Araihazar, Bangladesh

AU - Wasserman, Gail A.

AU - Liu, Xinhua

AU - Parvez, Faruque

AU - Chen, Yu

AU - Factor-Litvak, Pam

AU - LoIacono, Nancy J.

AU - Levy, Diane

AU - Shahriar, Hasan

AU - Uddin, Mohammed Nasir

AU - Islam, Tariqul

AU - Lomax, Angela

AU - Saxena, Roheeni

AU - Gibson, Elizabeth A.

AU - Kioumourtzoglou, Marianthi Anna

AU - Balac, Olgica

AU - Sanchez, Tiffany

AU - Kline, Jennie K.

AU - Santiago, David

AU - Ellis, Tyler

AU - van Geen, Alexander

AU - Graziano, Joseph H.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Background: Exposure to inorganic arsenic (As) from drinking water is associated with modest deficits in intellectual function in young children; it is unclear whether deficits occur during adolescence, when key brain functions are more fully developed. Objectives: We sought to determine the degree to which As exposure is associated with adolescent intelligence, and the contributory roles of lead, cadmium, manganese and selenium. Methods: We recruited a cross-section of 726 14–16 year olds (mean age = 14.8 years) whose mothers are participants in the Bangladesh Health Effects of Arsenic Longitudinal Study (HEALS), and whose household well water As levels, which varied widely, were well characterized. Using a culturally modified version of the WISC-IV, we examined raw Full Scale scores, and Verbal Comprehension, Perceptual Reasoning, Working Memory and Processing Speed Indices. Blood levels of As (BAs), Mn, Pb, Cd and Se were assessed at the time of the visit, as was creatinine-adjusted urinary As (UAs/Cr). Results: Linear regression analyses revealed that BAs was significantly negatively associated with all WISC-IV scores except for Perceptual Reasoning. With UAs/Cr as the exposure variable, we observed significantly negative associations for all WISC-IV scores. Except for Se, blood levels of other metals, were also associated with lower WISC-IV scores. Controlling for covariates, doubling BAs, or UAs/Cr, was associated with a mean decrement (95% CI) of 3.3 (1.1, 5.5), or 3.0 (1.2, 4.5) points, respectively, in raw Full scale scores with a sample mean of 177.6 (SD = 36.8). Confirmatory analyses using Bayesian Kernel Machine Regression, which identifies important mixture members, supported these findings; the primary contributor of the mixture was BAs, followed by BCd. Conclusions: Our data indicate that the adverse consequences of As exposure on neurodevelopment observed in other cross-sectional studies of younger children are also apparent during adolescence. They also implicate Cd as a neurotoxic element that deserves more attention.

AB - Background: Exposure to inorganic arsenic (As) from drinking water is associated with modest deficits in intellectual function in young children; it is unclear whether deficits occur during adolescence, when key brain functions are more fully developed. Objectives: We sought to determine the degree to which As exposure is associated with adolescent intelligence, and the contributory roles of lead, cadmium, manganese and selenium. Methods: We recruited a cross-section of 726 14–16 year olds (mean age = 14.8 years) whose mothers are participants in the Bangladesh Health Effects of Arsenic Longitudinal Study (HEALS), and whose household well water As levels, which varied widely, were well characterized. Using a culturally modified version of the WISC-IV, we examined raw Full Scale scores, and Verbal Comprehension, Perceptual Reasoning, Working Memory and Processing Speed Indices. Blood levels of As (BAs), Mn, Pb, Cd and Se were assessed at the time of the visit, as was creatinine-adjusted urinary As (UAs/Cr). Results: Linear regression analyses revealed that BAs was significantly negatively associated with all WISC-IV scores except for Perceptual Reasoning. With UAs/Cr as the exposure variable, we observed significantly negative associations for all WISC-IV scores. Except for Se, blood levels of other metals, were also associated with lower WISC-IV scores. Controlling for covariates, doubling BAs, or UAs/Cr, was associated with a mean decrement (95% CI) of 3.3 (1.1, 5.5), or 3.0 (1.2, 4.5) points, respectively, in raw Full scale scores with a sample mean of 177.6 (SD = 36.8). Confirmatory analyses using Bayesian Kernel Machine Regression, which identifies important mixture members, supported these findings; the primary contributor of the mixture was BAs, followed by BCd. Conclusions: Our data indicate that the adverse consequences of As exposure on neurodevelopment observed in other cross-sectional studies of younger children are also apparent during adolescence. They also implicate Cd as a neurotoxic element that deserves more attention.

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