A CMOS Electrochemical Biochip with 32 × 32 Three-Electrode Voltammetry Pixels

Arun Manickam, Kae Dyi You, Nicholas Wood, Lei Pei, Yang Liu, Rituraj Singh, Nader Gamini, Mark W. McDermott, Davood Shahrjerdi, Robert G. Kuimelis, Arjang Hassibi

Research output: Contribution to journalArticle

Abstract

A CMOS-integrated electrochemical biochip for high-performance molecular testing is presented. The system includes an array of 32 × 32 three-electrode voltammetry pixels and on-chip temperature control between 25 and 95 °C. Each 100 μm × 100 μm pixel includes a CMOS-compatible and chemo-stable amorphous carbon electrode transducer connected to in-pixel ΣΔ current detection circuitry with 280 fA rms input-referred noise (0.1-20 Hz bandwidth) and 93 dB dynamic range (DR). Array-based DNA detection assays are implemented, and successful DNA melt-analysis and real-time label-free DNA hybridization detection are reported.

Original languageEnglish (US)
Article number8869863
Pages (from-to)2980-2990
Number of pages11
JournalIEEE Journal of Solid-State Circuits
Volume54
Issue number11
DOIs
StatePublished - Nov 2019

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Biochips
Voltammetry
DNA
Pixels
Electrodes
Amorphous carbon
Temperature control
Labels
Transducers
Assays
Bandwidth
Testing

Keywords

  • Biochip
  • biosensor
  • DNA sequencing
  • electrochemical
  • lab-on-chip
  • microarrays
  • molecular diagnostics (MDx)
  • nucleic acid
  • voltammetry

ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Manickam, A., You, K. D., Wood, N., Pei, L., Liu, Y., Singh, R., ... Hassibi, A. (2019). A CMOS Electrochemical Biochip with 32 × 32 Three-Electrode Voltammetry Pixels. IEEE Journal of Solid-State Circuits, 54(11), 2980-2990. [8869863]. https://doi.org/10.1109/JSSC.2019.2941020

A CMOS Electrochemical Biochip with 32 × 32 Three-Electrode Voltammetry Pixels. / Manickam, Arun; You, Kae Dyi; Wood, Nicholas; Pei, Lei; Liu, Yang; Singh, Rituraj; Gamini, Nader; McDermott, Mark W.; Shahrjerdi, Davood; Kuimelis, Robert G.; Hassibi, Arjang.

In: IEEE Journal of Solid-State Circuits, Vol. 54, No. 11, 8869863, 11.2019, p. 2980-2990.

Research output: Contribution to journalArticle

Manickam, A, You, KD, Wood, N, Pei, L, Liu, Y, Singh, R, Gamini, N, McDermott, MW, Shahrjerdi, D, Kuimelis, RG & Hassibi, A 2019, 'A CMOS Electrochemical Biochip with 32 × 32 Three-Electrode Voltammetry Pixels', IEEE Journal of Solid-State Circuits, vol. 54, no. 11, 8869863, pp. 2980-2990. https://doi.org/10.1109/JSSC.2019.2941020
Manickam, Arun ; You, Kae Dyi ; Wood, Nicholas ; Pei, Lei ; Liu, Yang ; Singh, Rituraj ; Gamini, Nader ; McDermott, Mark W. ; Shahrjerdi, Davood ; Kuimelis, Robert G. ; Hassibi, Arjang. / A CMOS Electrochemical Biochip with 32 × 32 Three-Electrode Voltammetry Pixels. In: IEEE Journal of Solid-State Circuits. 2019 ; Vol. 54, No. 11. pp. 2980-2990.
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