3D of brain shape and volume after cranial vault remodeling surgery for craniosynostosis correction in infants

Beatriz Paniagua, Omri Emodi, Jonathan Hill, James Fishbaugh, Luiz A. Pimenta, Stephen R. Aylward, Enquobahrie Andinet, Guido Gerig, John Gilmore, John A. Van Aalst, Martin Styner

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The skull of young children is made up of bony plates that enable growth. Craniosynostosis is a birth defect that causes one or more sutures on an infant's skull to close prematurely. Corrective surgery focuses on cranial and orbital rim shaping to return the skull to a more normal shape. Functional problems caused by craniosynostosis such as speech and motor delay can improve after surgical correction, but a post-surgical analysis of brain development in comparison with age-matched healthy controls is necessary to assess surgical outcome. Full brain segmentations obtained from pre- and post-operative computed tomography (CT) scans of 8 patients with single suture sagittal (n=5) and metopic (n=3), nonsyndromic craniosynostosis from 41 to 452 days-of-age were included in this study. Age-matched controls obtained via 4D acceleration-based regression of a cohort of 402 full brain segmentations from healthy controls magnetic resonance images (MRI) were also used for comparison (ages 38 to 825 days). 3D point-based models of patient and control cohorts were obtained using SPHARM-PDM shape analysis tool. From a full dataset of regressed shapes, 240 healthy regressed shapes between 30 and 588 days-of-age (time step = 2.34 days) were selected. Volumes and shape metrics were obtained for craniosynostosis and healthy age-matched subjects. Volumes and shape metrics in single suture craniosynostosis patients were larger than age-matched controls for pre- and post-surgery. The use of 3D shape and volumetric measurements show that brain growth is not normal in patients with single suture craniosynostosis.

    Original languageEnglish (US)
    Title of host publicationMedical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging
    Volume8672
    DOIs
    StatePublished - 2013
    EventMedical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging - Lake Buena Vista, FL, United States
    Duration: Feb 10 2013Feb 13 2013

    Other

    OtherMedical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging
    CountryUnited States
    CityLake Buena Vista, FL
    Period2/10/132/13/13

    Fingerprint

    Craniosynostoses
    surgery
    Surgery
    brain
    Brain
    Sutures
    skull
    Skull
    Language Development Disorders
    Magnetic resonance
    Growth Plate
    Pulse width modulation
    Tomography
    pulse duration modulation
    rims
    Magnetic Resonance Spectroscopy
    magnetic resonance
    Defects
    regression analysis
    tomography

    Keywords

    • Pediatric neuroimaging
    • Plastic surgery
    • Shape analysis
    • Shape regression
    • Volumetric analysis

    ASJC Scopus subject areas

    • Atomic and Molecular Physics, and Optics
    • Electronic, Optical and Magnetic Materials
    • Biomaterials
    • Radiology Nuclear Medicine and imaging

    Cite this

    Paniagua, B., Emodi, O., Hill, J., Fishbaugh, J., Pimenta, L. A., Aylward, S. R., ... Styner, M. (2013). 3D of brain shape and volume after cranial vault remodeling surgery for craniosynostosis correction in infants. In Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging (Vol. 8672). [86720V] https://doi.org/10.1117/12.2006524

    3D of brain shape and volume after cranial vault remodeling surgery for craniosynostosis correction in infants. / Paniagua, Beatriz; Emodi, Omri; Hill, Jonathan; Fishbaugh, James; Pimenta, Luiz A.; Aylward, Stephen R.; Andinet, Enquobahrie; Gerig, Guido; Gilmore, John; Van Aalst, John A.; Styner, Martin.

    Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 8672 2013. 86720V.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Paniagua, B, Emodi, O, Hill, J, Fishbaugh, J, Pimenta, LA, Aylward, SR, Andinet, E, Gerig, G, Gilmore, J, Van Aalst, JA & Styner, M 2013, 3D of brain shape and volume after cranial vault remodeling surgery for craniosynostosis correction in infants. in Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging. vol. 8672, 86720V, Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging, Lake Buena Vista, FL, United States, 2/10/13. https://doi.org/10.1117/12.2006524
    Paniagua B, Emodi O, Hill J, Fishbaugh J, Pimenta LA, Aylward SR et al. 3D of brain shape and volume after cranial vault remodeling surgery for craniosynostosis correction in infants. In Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 8672. 2013. 86720V https://doi.org/10.1117/12.2006524
    Paniagua, Beatriz ; Emodi, Omri ; Hill, Jonathan ; Fishbaugh, James ; Pimenta, Luiz A. ; Aylward, Stephen R. ; Andinet, Enquobahrie ; Gerig, Guido ; Gilmore, John ; Van Aalst, John A. ; Styner, Martin. / 3D of brain shape and volume after cranial vault remodeling surgery for craniosynostosis correction in infants. Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 8672 2013.
    @inproceedings{54ff19549d604f7dbbd2f46b06efc12b,
    title = "3D of brain shape and volume after cranial vault remodeling surgery for craniosynostosis correction in infants",
    abstract = "The skull of young children is made up of bony plates that enable growth. Craniosynostosis is a birth defect that causes one or more sutures on an infant's skull to close prematurely. Corrective surgery focuses on cranial and orbital rim shaping to return the skull to a more normal shape. Functional problems caused by craniosynostosis such as speech and motor delay can improve after surgical correction, but a post-surgical analysis of brain development in comparison with age-matched healthy controls is necessary to assess surgical outcome. Full brain segmentations obtained from pre- and post-operative computed tomography (CT) scans of 8 patients with single suture sagittal (n=5) and metopic (n=3), nonsyndromic craniosynostosis from 41 to 452 days-of-age were included in this study. Age-matched controls obtained via 4D acceleration-based regression of a cohort of 402 full brain segmentations from healthy controls magnetic resonance images (MRI) were also used for comparison (ages 38 to 825 days). 3D point-based models of patient and control cohorts were obtained using SPHARM-PDM shape analysis tool. From a full dataset of regressed shapes, 240 healthy regressed shapes between 30 and 588 days-of-age (time step = 2.34 days) were selected. Volumes and shape metrics were obtained for craniosynostosis and healthy age-matched subjects. Volumes and shape metrics in single suture craniosynostosis patients were larger than age-matched controls for pre- and post-surgery. The use of 3D shape and volumetric measurements show that brain growth is not normal in patients with single suture craniosynostosis.",
    keywords = "Pediatric neuroimaging, Plastic surgery, Shape analysis, Shape regression, Volumetric analysis",
    author = "Beatriz Paniagua and Omri Emodi and Jonathan Hill and James Fishbaugh and Pimenta, {Luiz A.} and Aylward, {Stephen R.} and Enquobahrie Andinet and Guido Gerig and John Gilmore and {Van Aalst}, {John A.} and Martin Styner",
    year = "2013",
    doi = "10.1117/12.2006524",
    language = "English (US)",
    isbn = "9780819494467",
    volume = "8672",
    booktitle = "Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging",

    }

    TY - GEN

    T1 - 3D of brain shape and volume after cranial vault remodeling surgery for craniosynostosis correction in infants

    AU - Paniagua, Beatriz

    AU - Emodi, Omri

    AU - Hill, Jonathan

    AU - Fishbaugh, James

    AU - Pimenta, Luiz A.

    AU - Aylward, Stephen R.

    AU - Andinet, Enquobahrie

    AU - Gerig, Guido

    AU - Gilmore, John

    AU - Van Aalst, John A.

    AU - Styner, Martin

    PY - 2013

    Y1 - 2013

    N2 - The skull of young children is made up of bony plates that enable growth. Craniosynostosis is a birth defect that causes one or more sutures on an infant's skull to close prematurely. Corrective surgery focuses on cranial and orbital rim shaping to return the skull to a more normal shape. Functional problems caused by craniosynostosis such as speech and motor delay can improve after surgical correction, but a post-surgical analysis of brain development in comparison with age-matched healthy controls is necessary to assess surgical outcome. Full brain segmentations obtained from pre- and post-operative computed tomography (CT) scans of 8 patients with single suture sagittal (n=5) and metopic (n=3), nonsyndromic craniosynostosis from 41 to 452 days-of-age were included in this study. Age-matched controls obtained via 4D acceleration-based regression of a cohort of 402 full brain segmentations from healthy controls magnetic resonance images (MRI) were also used for comparison (ages 38 to 825 days). 3D point-based models of patient and control cohorts were obtained using SPHARM-PDM shape analysis tool. From a full dataset of regressed shapes, 240 healthy regressed shapes between 30 and 588 days-of-age (time step = 2.34 days) were selected. Volumes and shape metrics were obtained for craniosynostosis and healthy age-matched subjects. Volumes and shape metrics in single suture craniosynostosis patients were larger than age-matched controls for pre- and post-surgery. The use of 3D shape and volumetric measurements show that brain growth is not normal in patients with single suture craniosynostosis.

    AB - The skull of young children is made up of bony plates that enable growth. Craniosynostosis is a birth defect that causes one or more sutures on an infant's skull to close prematurely. Corrective surgery focuses on cranial and orbital rim shaping to return the skull to a more normal shape. Functional problems caused by craniosynostosis such as speech and motor delay can improve after surgical correction, but a post-surgical analysis of brain development in comparison with age-matched healthy controls is necessary to assess surgical outcome. Full brain segmentations obtained from pre- and post-operative computed tomography (CT) scans of 8 patients with single suture sagittal (n=5) and metopic (n=3), nonsyndromic craniosynostosis from 41 to 452 days-of-age were included in this study. Age-matched controls obtained via 4D acceleration-based regression of a cohort of 402 full brain segmentations from healthy controls magnetic resonance images (MRI) were also used for comparison (ages 38 to 825 days). 3D point-based models of patient and control cohorts were obtained using SPHARM-PDM shape analysis tool. From a full dataset of regressed shapes, 240 healthy regressed shapes between 30 and 588 days-of-age (time step = 2.34 days) were selected. Volumes and shape metrics were obtained for craniosynostosis and healthy age-matched subjects. Volumes and shape metrics in single suture craniosynostosis patients were larger than age-matched controls for pre- and post-surgery. The use of 3D shape and volumetric measurements show that brain growth is not normal in patients with single suture craniosynostosis.

    KW - Pediatric neuroimaging

    KW - Plastic surgery

    KW - Shape analysis

    KW - Shape regression

    KW - Volumetric analysis

    UR - http://www.scopus.com/inward/record.url?scp=84878292098&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=84878292098&partnerID=8YFLogxK

    U2 - 10.1117/12.2006524

    DO - 10.1117/12.2006524

    M3 - Conference contribution

    AN - SCOPUS:84878292098

    SN - 9780819494467

    VL - 8672

    BT - Medical Imaging 2013: Biomedical Applications in Molecular, Structural, and Functional Imaging

    ER -