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Yingkai Zhang

Professor of Chemistry

1993 …2019
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Fingerprint Weighted list of dominant concepts in the researcher's publications (titles and abstracts).

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Molecular dynamics Chemical Compounds
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Research Output 1993 2019

  • 89 Article
  • 2 Chapter (peer-reviewed)
  • 1 Chapter
  • 1 Comment/debate

Identification and structure-function analyses of an allosteric inhibitor of the tyrosine phosphatase PTPN22

Li, K., Hou, X., Li, R., Bi, W., Yang, F., Chen, X., Xiao, P., Liu, T., Lu, T., Zhou, Y., Tian, Z., Shen, Y., Zhang, Y., Wang, J., Fang, H., Sun, J. & Yu, X., Jan 1 2019, In : Journal of Biological Chemistry. 294, 21, p. 8653-8663 11 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Phosphatases
Phosphoric Monoester Hydrolases
Tyrosine
Allosteric Site

Intrinsic cleavage of RNA polymerase II adopts a nucleobase-independent mechanism assisted by transcript phosphate

Tse, C. K. M., Xu, J., Xu, L., Sheong, F. K., Wang, S., Chow, H. Y., Gao, X., Li, X., Cheung, P. P. H., Wang, D., Zhang, Y. & Huang, X., Mar 1 2019, In : Nature Catalysis. 2, 3, p. 228-235 8 p.

Research output: Contribution to journalArticle

RNA Polymerase II
RNA
Phosphates
Oxygen
Mechanics
field theory (physics)
Tensors
tensors
Neural networks
learning

Two symmetric arginine residues play distinct roles in thermus thermophilus argonaute DNA guide strand-mediated DNA target cleavage

Lei, J., Sheng, G., Cheung, P. P. H., Wang, S., Li, Y., Gao, X., Zhang, Y., Wang, Y. & Huang, X., Jan 15 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 3, p. 845-853 9 p.

Research output: Contribution to journalArticle

R 486
Thermus thermophilus
DNA Cleavage
Arginine
DNA

Computational Strategy for Bound State Structure Prediction in Structure-Based Virtual Screening: A Case Study of Protein Tyrosine Phosphatase Receptor Type O Inhibitors

Hou, X., Rooklin, D., Yang, D., Liang, X., Li, K., Lu, J., Wang, C., Xiao, P., Zhang, Y., Sun, J. P. & Fang, H., Jan 1 2018, (Accepted/In press) In : Journal of Chemical Information and Modeling.

Research output: Contribution to journalArticle

Class 3 Receptor-Like Protein Tyrosine Phosphatases
Phosphatases
Screening
Proteins
Ligands