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Xin Li

Associate Professor

    20002019
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    Research Output 2000 2019

    2019

    Circulating IGF-1 promotes prostate adenocarcinoma via FOXO3A/BIM signaling in a double-transgenic mouse model

    Wang, S., Wang, N., Yu, B., Cao, M., Wang, Y., Guo, Y., Zhang, Y., Zhang, P., Yu, X., Wang, S., Zeng, L., Liang, B., Li, X. & Wu, Y., Sep 5 2019, In : Oncogene. 38, 36, p. 6338-6353 16 p.

    Research output: Contribution to journalArticle

    Somatomedins
    Transgenic Mice
    Prostate
    Adenocarcinoma
    Prostatic Neoplasms

    Inhibition of Karyopherin beta 1 suppresses prostate cancer growth

    Yang, J., Guo, Y., Lu, C., Zhang, R., Wang, Y., Luo, L., Zhang, Y., Chu, C. H., Wang, K. J., Obbad, S., Yan, W. & Li, X., Jan 1 2019, In : Oncogene.

    Research output: Contribution to journalArticle

    beta Karyopherins
    Prostatic Neoplasms
    Growth
    Cell Cycle
    Karyopherins

    Loss of Adipose Growth Hormone Receptor in Mice Enhances Local Fatty Acid Trapping and Impairs Brown Adipose Tissue Thermogenesis

    Ran, L., Wang, X., Mi, A., Liu, Y., Wu, J., Wang, H., Guo, M., Sun, J., Liu, B., Li, Y., Wang, D., Jiang, R., Wang, N., Gao, W., Zeng, L., Huang, L., Chen, X., LeRoith, D., Liang, B., Li, X. & 1 others, Wu, Y., Jun 28 2019, In : iScience. 16, p. 106-121 16 p.

    Research output: Contribution to journalArticle

    Open Access
    Somatotropin Receptors
    Brown Adipose Tissue
    Thermogenesis
    Fatty Acids
    Endocrinology

    Targeting cellular metabolism to reduce head and neck cancer growth

    Yang, J., Guo, Y., Seo, W., Zhang, R., Lu, C., Wang, Y., Luo, L., Paul, B., Yan, W., Saxena, D. & Li, X., Dec 1 2019, In : Scientific Reports. 9, 1, 4995.

    Research output: Contribution to journalArticle

    Open Access
    Glutaminase
    Head and Neck Neoplasms
    Metformin
    Growth
    Glutamine
    2017

    Inhibition of KPNA4 attenuates prostate cancer metastasis

    Yang, J., Lu, C., Wei, J., Guo, Y., Liu, W., Luo, L., Fisch, G. & Li, X., May 18 2017, In : Oncogene. 36, 20, p. 2868-2878 11 p.

    Research output: Contribution to journalArticle

    Prostatic Neoplasms
    Neoplasm Metastasis
    Tumor Necrosis Factor-alpha
    Biomarkers
    Karyopherins

    Metformin inhibits SUV39H1-mediated migration of prostate cancer cells

    Yu, T., Wang, C., Yang, J., Guo, Y., Wu, Y. & Li, X., Jan 1 2017, In : Oncogenesis. 6, 5, e324.

    Research output: Contribution to journalArticle

    Metformin
    Prostatic Neoplasms
    Cell Movement
    Focal Adhesion Protein-Tyrosine Kinases
    Neoplasms

    Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis

    Guo, Y., Xie, C., Li, X., Yang, J., Yu, T., Zhang, R., Zhang, T., Saxena, D., Snyder, M., Wu, Y. & Li, X., May 31 2017, In : Nature Communications. 8, 15621.

    Research output: Contribution to journalArticle

    diabetes mellitus
    Succinic Acid
    G-Protein-Coupled Receptors
    Mesenchymal Stromal Cells
    Osteogenesis
    2016

    Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation

    Daniels, G., Zhang, X., Zhong, X., Santiago, L., Wang, L. H., Wu, X., Zhang, J. Y., Liang, F., Li, X., Neubert, T. A., Steinke, L., Shen, Y., Basch, R., Schneider, R., Levy, D. E. & Lee, P., 2016, In : Oncotarget. 7, 26, p. 39556-39571 16 p.

    Research output: Contribution to journalArticle

    Androgens
    Prostatic Neoplasms
    Apoptosis
    Prostate
    Nuclear Export Signals

    Nuclear TBLR1 as an ER corepressor promotes cell proliferation, migration and invasion in breast and ovarian cancer

    Wu, X., Zhan, Y., Li, X., Wei, J., Santiago, L., Daniels, G., Deng, F., Zhong, X., Chiriboga, L., Basch, R., Xiong, S., Dong, Y., Zhang, X. & Lee, P., 2016, In : American Journal of Cancer Research. 6, 10, p. 2351-2360 10 p.

    Research output: Contribution to journalArticle

    Co-Repressor Proteins
    Estrogen Receptors
    Ovarian Neoplasms
    Cell Movement
    Cell Proliferation
    2015

    BRONJ: The perfect storm (invited review)

    Alzaki, A., Fleisher, K. E., Glickman, R., Li, X. & Saxena, D., 2015, In : Oral Diseases.

    Research output: Contribution to journalLiterature review

    LEF1 targeting EMT in prostate cancer invasion is mediated by miR-181a

    Liang, J., Li, X., Li, Y., Wei, J., Daniels, G., Zhong, X., Wang, J., Sfanos, K., Melamed, J., Zhao, J. & Lee, P., 2015, In : American Journal of Cancer Research. 5, 3, p. 1124-1132

    Research output: Contribution to journalArticle

    LEF1 targeting EMT in prostate cancer invasion is regulated by miR-34a

    Liang, J., Li, Y., Daniels, G., Sfanos, K., De Marzo, A., Wei, J., Li, X., Chen, W., Wang, J., Zhong, X., Melamed, J., Zhao, J. & Lee, P., Apr 1 2015, In : Molecular Cancer Research. 13, 4, p. 681-688 8 p.

    Research output: Contribution to journalArticle

    Lymphoid Enhancer-Binding Factor 1
    Epithelial-Mesenchymal Transition
    MicroRNAs
    Prostatic Neoplasms
    Down-Regulation

    Metformin improves diabetic bone health by re-balancing catabolism and nitrogen disposal

    Li, X., Guo, Y., Yan, W., Snyder, M. P. & Li, X., Dec 1 2015, In : PLoS One. 10, 12, e0146152.

    Research output: Contribution to journalArticle

    metformin
    Metformin
    Bone
    Nitrogen
    bones

    Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer

    Yang, J., Wei, J., Wu, Y., Wang, Z., Guo, Y., Lee, P. & Li, X., 2015, In : Oncogenesis. 4, p. e158

    Research output: Contribution to journalArticle

    Metformin inhibits salivary adenocarcinoma growth through cell cycle arrest and apoptosis

    Guo, Y., Yu, T., Yang, J., Zhang, T., Zhou, Y., He, F., Kurago, Z., Myssiorek, D., Wu, Y., Lee, P. & Li, X., 2015, In : American Journal of Cancer Research. 5, 12, p. 3600-3611 12 p.

    Research output: Contribution to journalArticle

    Metformin
    Cell Cycle Checkpoints
    Adenocarcinoma
    Apoptosis
    Growth
    2014

    Induced expression of nucleolin phosphorylation-deficient mutant confers dominant-negative effect on cell proliferation

    Xiao, S., Caglar, E., Maldonado, P., Das, D., Nadeem, Z., Chi, A., Trinité, B., Li, X. & Saxena, A., Oct 14 2014, In : PLoS One. 9, 10, e109858.

    Research output: Contribution to journalArticle

    Phosphorylation
    Cell proliferation
    cell proliferation
    phosphorylation
    Cell Proliferation

    Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw

    Pushalkar, S., Li, X., Kurago, Z., Ramanathapuram, L. V., Matsumura, S., Fleisher, K. E., Glickman, R., Yan, W., Li, Y. & Saxena, D., Dec 11 2014, In : International journal of oral science. 6, 4, p. 219-226 8 p.

    Research output: Contribution to journalArticle

    Bisphosphonate-Associated Osteonecrosis of the Jaw
    Microbiota
    Diphosphonates
    Innate Immunity
    Periodontal Diseases
    2013

    Impact of diabetes and its treatments on skeletal diseases

    Yan, W. & Li, X., 2013, In : Frontiers of Medicine in China. 7, 1, p. 81-90 10 p.

    Research output: Contribution to journalArticle

    Type 2 Diabetes Mellitus
    Type 1 Diabetes Mellitus
    Hyperglycemia
    Bone Density
    Anabolic Agents

    Metformin targets c-MYC oncogene to prevent prostate cancer

    Akinyeke, T., Matsumura, S., Wang, X., Wu, Y., Schalfer, E. D., Saxena, A., Yan, W., Logan, S. K. & Li, X., Dec 2013, In : Carcinogenesis. 34, 12, p. 2823-2832 10 p.

    Research output: Contribution to journalArticle

    Metformin
    Oncogenes
    Prostatic Neoplasms
    Prostate
    Proto-Oncogene Proteins c-myc

    The effects of zoledronic acid in the bone and vasculature support of hematopoietic stem cell niches

    Soki, F. N., Li, X., Berry, J., Koh, A., Sinder, B. P., Qian, X., Kozloff, K. M., Taichman, R. S. & McCauley, L. K., Jan 2013, In : Journal of Cellular Biochemistry. 114, 1, p. 67-78 12 p.

    Research output: Contribution to journalArticle

    zoledronic acid
    Stem Cell Niche
    Hematopoietic Stem Cells
    Stem cells
    Bone
    2012

    Comparison of oral microbiota in tumor and non-tumor tissues of patients with oral squamous cell carcinoma.

    Pushalkar, S., Ji, X., Li, Y., Estilo, C., Yegnanarayana, R., Singh, B., Li, X. & Saxena, D., 2012, In : BMC Microbiology. 12, 144.

    Research output: Contribution to journalArticle

    Microbiota
    Squamous Cell Carcinoma
    Neoplasms
    Gemella
    Denaturing Gradient Gel Electrophoresis

    Cyclophosphamide creates a receptive microenvironment for prostate cancer skeletal metastasis

    Park, S. I., Liao, J., Berry, J. E., Li, X., Koh, A. J., Michalski, M. E., Eber, M. R., Soki, F. N., Sadler, D., Sud, H., Tisdelle, S., Daignault, S. D., Nemeth, J. A., Snyder, L. A., Wronski, T. J., Pienta, K. J. & McCauley, L. K., May 15 2012, In : Cancer Research. 72, 10, p. 2522-2532 11 p.

    Research output: Contribution to journalArticle

    Cyclophosphamide
    Prostatic Neoplasms
    Bone Marrow
    Neoplasm Metastasis
    Bone and Bones
    2011

    An irradiation-altered bone marrow microenvironment impacts anabolic actions of PTH

    Koh, A. J., Novince, C. M., Li, X., Wang, T., Taichman, R. S. & McCauley, L. K., Dec 2011, In : Endocrinology. 152, 12, p. 4525-4536 12 p.

    Research output: Contribution to journalArticle

    Bone Marrow
    Osteoclasts
    Osteoblasts
    Osteogenesis
    Nestin

    Drugs which inhibit osteoclast function suppress tumor growth through calcium reduction in bone

    Li, X., Liao, J., Park, S. I., Koh, A. J., Sadler, W. D., Pienta, K. J., Rosol, T. J. & McCauley, L. K., Jun 1 2011, In : Bone. 48, 6, p. 1354-1361 8 p.

    Research output: Contribution to journalArticle

    zoledronic acid
    Osteoclasts
    Calcium
    Bone and Bones
    Bone Resorption

    Inhibitory effects of megakaryocytic cells in prostate cancer skeletal metastasis

    Li, X., Koh, A. J., Wang, Z., Soki, F. N., Park, S. I., Pienta, K. J. & McCauley, L. K., Jan 2011, In : Journal of Bone and Mineral Research. 26, 1, p. 125-134 10 p.

    Research output: Contribution to journalArticle

    Prostatic Neoplasms
    Neoplasm Metastasis
    Megakaryocytes
    Prostate
    K562 Cells
    2009

    A destructive cascade mediated by CCL2 facilitates prostate cancer growth in bone

    Li, X., Loberg, R., Liao, J., Ying, C., Snyder, L. A., Pienta, K. J. & McCauley, L. K., Feb 15 2009, In : Cancer Research. 69, 4, p. 1685-1692 8 p.

    Research output: Contribution to journalArticle

    Parathyroid Hormone-Related Protein
    Bone Development
    Prostatic Neoplasms
    Endothelial Cells
    Conditioned Culture Medium
    2008

    In vivo parathyroid hormone treatments and RNA isolation and analysis

    Li, X., Ling, Q. & Nicola, C. P., 2008, Osteoporosis: Methods and Protocols. Humana Press, Vol. 455. p. 79-87 9 p. (Methods in Molecular Biology; vol. 455).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Parathyroid Hormone
    RNA
    Bone and Bones
    Therapeutics
    Gene Expression

    Osteonecrosis of the jaw: Meeting report from skeletal complications of malignancy V

    Li, X. & McCauley, L. K., 2008, In : IBMS BoneKEy. 5, 8, p. 289-293

    Research output: Contribution to journalArticle

    Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions

    Liao, J., Li, X., Koh, A. J., Berry, J. E., Thudi, N., Rosol, T. J., Pienta, K. J. & McCauley, L. K., Nov 15 2008, In : International Journal of Cancer. 123, 10, p. 2267-2278 12 p.

    Research output: Contribution to journalArticle

    Parathyroid Hormone-Related Protein
    Prostatic Neoplasms
    Neoplasms
    Parathyroid Neoplasms
    Mesenchymal Stromal Cells
    2007

    Distinguishing features of the oral cavity and its predisposition to osteonecrosis.

    McCauley, L. K. & Li, X., Oct 2007, In : Journal of musculoskeletal & neuronal interactions. 7, 4, p. 356-357 2 p.

    Research output: Contribution to journalArticle

    Mandibular Diseases
    Jaw Diseases
    Bone Regeneration
    Osteonecrosis
    Dental Care
    2002

    Progresses in molecular biology of polydnaviruses

    Li, X., Qin, Q. L. & Ding, C., 2002, In : Entomological Knowledge. 39, 1

    Research output: Contribution to journalArticle

    2001

    Characterization of microplitis mediator polydnavirus

    Li, X., Qin, Q. L., Ding, C. & Liu, H. H., 2001, In : Virologica Sinica. 16, 4, p. 373-376

    Research output: Contribution to journalArticle

    2000