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Weiqiang Chen

Assistant Professor

20062019
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Research Output 2006 2019

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2019

Biophysical Phenotyping and Modulation of ALDH+ Inflammatory Breast Cancer Stem-Like Cells

Chen, W., Allen, S. G., Qian, W., Peng, Z., Han, S., Li, X., Sun, Y., Fournier, C., Bao, L., Lam, R. H. W., Merajver, S. D. & Fu, J., Jan 1 2019, (Accepted/In press) In : Small. 1802891.

Research output: Contribution to journalArticle

Inflammatory Breast Neoplasms
Neoplastic Stem Cells
Modulation
Bond strength (materials)
Formability

Cellogram: On-the-Fly Traction Force Microscopy

Lendenmann, T., Schneider, T., Dumas, J., Tarini, M., Giampietro, C., Bajpai, A., Chen, W., Gerber, J., Poulikakos, D., Ferrari, A. & Panozzo, D., Oct 9 2019, In : Nano Letters. 19, 10, p. 6742-6750 9 p.

Research output: Contribution to journalArticle

traction
Microscopic examination
microscopy
Image processing
Cells

Energy-Mediated Machinery Drives Cellular Mechanical Allostasis

Wang, Q., Qian, W., Xu, X., Bajpai, A., Guan, K., Zhang, Z., Chen, R., Flamini, V. & Chen, W., Jan 1 2019, In : Advanced Materials. 1900453.

Research output: Contribution to journalArticle

Machinery
Mechanics
Energy barriers
Stabilization
Aging of materials

Magnet Patterned Superparamagnetic Fe3O4/Au Core–Shell Nanoplasmonic Sensing Array for Label-Free High Throughput Cytokine Immunoassay

Cai, Y., Zhu, J., He, J., Yang, W., Ma, C., Xiong, F., Li, F., Chen, W. & Chen, P., Jan 1 2019, (Accepted/In press) In : Advanced healthcare materials. 1801478.

Research output: Contribution to journalArticle

Magnets
Microarrays
Immunoassay
Labels
Immunologic Monitoring

Probing Single-Cell Mechanical Allostasis Using Ultrasound Tweezers

Qian, W. & Chen, W., Jan 1 2019, In : Cellular and Molecular Bioengineering.

Research output: Contribution to journalArticle

Allostasis
Actomyosin
Ultrasound
Ultrasonics
Medical problems

The Interplay Between Cell-Cell and Cell-Matrix Forces Regulates Cell Migration Dynamics

Bajpai, A., Tong, J., Qian, W., Peng, Y. & Chen, W., Nov 19 2019, In : Biophysical Journal. 117, 10, p. 1795-1804 10 p.

Research output: Contribution to journalArticle

Cell Movement
Traction
Extracellular Matrix
Wound Healing
Embryonic Development
2018

A fluorescent microbead-based microfluidic immunoassay chip for immune cell cytokine secretion quantification

Cui, X., Liu, Y., Hu, D., Qian, W., Tin, C., Sun, D., Chen, W. & Lam, R. H. W., Jan 1 2018, In : Lab on a Chip. 18, 3, p. 522-531 10 p.

Research output: Contribution to journalArticle

Microfluidics
Microspheres
Immunoassay
Cytokines
Lab-On-A-Chip Devices

An integrated adipose-tissue-on-chip nanoplasmonic biosensing platform for investigating obesity-associated inflammation

Zhu, J., He, J., Verano, M., Brimmo, A. T., Glia, A., Qasaimeh, M., Chen, P., Aleman, J. O. & Chen, W., Dec 7 2018, In : Lab on a Chip. 18, 23, p. 3550-3560 11 p.

Research output: Contribution to journalArticle

Adipose Tissue
Obesity
Tissue
Cytokines
Inflammation

A Photoresponsive Hyaluronan Hydrogel Nanocomposite for Dynamic Macrophage Immunomodulation

Wang, H., Morales, R. T. T., Cui, X., Huang, J., Qian, W., Tong, J. & Chen, W., Jan 1 2018, (Accepted/In press) In : Advanced healthcare materials. 1801234.

Research output: Contribution to journalArticle

Nanocomposites
Immunomodulation
Macrophages
Hydrogel
Hyaluronic Acid

Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis

Cui, X., Morales, R. T. T., Qian, W., Wang, H., Gagner, J. P., Dolgalev, I., Placantonakis, D., Zagzag, D., Cimmino, L., Snuderl, M., Lam, R. H. W. & Chen, W., Apr 1 2018, In : Biomaterials. 161, p. 164-178 15 p.

Research output: Contribution to journalArticle

Macrophages
Glioblastoma
Immunosuppression
Tumors
Immunosuppressive Agents

Nanotopography regulates motor neuron differentiation of human pluripotent stem cells

Chen, W., Han, S., Qian, W., Weng, S., Yang, H., Sun, Y., Villa-Diaz, L. G., Krebsbach, P. H. & Fu, J., Feb 21 2018, In : Nanoscale. 10, 7, p. 3556-3565 10 p.

Research output: Contribution to journalArticle

Stem cells
Neurons
Actomyosin
Cell adhesion
Reactive ion etching
2017

Nanotopographic Regulation of Human Mesenchymal Stem Cell Osteogenesis

Qian, W., Gong, L., Cui, X., Zhang, Z., Bajpai, A., Liu, C., Castillo, A., Teo, J. & Chen, W., Dec 6 2017, In : ACS Applied Materials and Interfaces. 9, 48, p. 41794-41806 13 p.

Research output: Contribution to journalArticle

Stem cells
Dexamethasone
Modulators
Bone
Adhesion
2016

Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis

Weng, S., Shao, Y., Chen, W. & Fu, J., May 30 2016, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalArticle

homeostasis
adhesion
Adhesion
cells
Integrins

Multiparametric Biomechanical and Biochemical Phenotypic Profiling of Single Cancer Cells Using an Elasticity Microcytometer

Hu, S., Liu, G., Chen, W., Li, X., Lu, W., Lam, R. H. W. & Fu, J., 2016, (Accepted/In press) In : Small.

Research output: Contribution to journalArticle

Elasticity
Cells
Neoplasms
Formability
Microfluidics

Nanoroughened adhesion-based capture of circulating tumor cells with heterogeneous expression and metastatic characteristics

Chen, W., Allen, S. G., Reka, A. K., Qian, W., Han, S., Zhao, J., Bao, L., Keshamouni, V. G., Merajver, S. D. & Fu, J., Aug 8 2016, In : BMC Cancer. 16, 1, 614.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Microfluidics
Glass
Neoplasms
Lung Neoplasms

Osteoblast-derived paracrine factors regulate angiogenesis in response to mechanical stimulation

Liu, C., Cui, X., Ackermann, T. M., Flamini, V., Chen, W. & Castillo, A., Jul 1 2016, In : Integrative Biology (United Kingdom). 8, 7, p. 785-794 10 p.

Research output: Contribution to journalArticle

Angiogenesis Inducing Agents
Osteoblasts
Endothelial cells
Conditioned Culture Medium
Endothelial Cells

Surface micromachining of polydimethylsiloxane for microfluidics applications

Hill, S., Qian, W., Chen, W. & Fu, J., Sep 1 2016, In : Biomicrofluidics. 10, 5, 054114.

Research output: Contribution to journalArticle

Microtechnology
Surface micromachining
Microfluidics
Polydimethylsiloxane
micromachining
2015

Capturing Cancer: Emerging Microfluidic Technologies for the Capture and Characterization of Circulating Tumor Cells

Qian, W., Zhang, Y. & Chen, W., Aug 1 2015, In : Small. 11, 32, p. 3850-3872 23 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Microfluidics
Tumors
Cells
Technology

Engineering Nanoscale Stem Cell Niche: Direct Stem Cell Behavior at Cell-Matrix Interface

Zhang, Y., Gordon, A., Qian, W. & Chen, W., Sep 1 2015, In : Advanced healthcare materials. 4, 13, p. 1900-1914 15 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Stem cells
Stem Cells
Cues
Regenerative Medicine

Nanotopographic Biomaterials for Isolation of Circulating Tumor Cells

Qian, W., Zhang, Y., Gordon, A. & Chen, W., Nov 1 2015, In : Journal of Nanotechnology in Engineering and Medicine. 5, 4, 040802.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Biocompatible Materials
Biomaterials
Tumors
Cells
2014

Continuous-flow microfluidic blood cell sorting for unprocessed whole blood using surface-micromachined microfiltration membranes

Li, X., Chen, W., Liu, G., Lu, W. & Fu, J., Jul 21 2014, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 14, 14, p. 2565-2575 11 p.

Research output: Contribution to journalArticle

Microfiltration
Microfluidics
Sorting
Blood Cells
Blood

Emerging microengineered tools for functional analysis and phenotyping of blood cells

Li, X., Chen, W., Li, Z., Li, L., Gu, H. & Fu, J., Nov 1 2014, In : Trends in Biotechnology. 32, 11, p. 586-594 9 p.

Research output: Contribution to journalArticle

Functional analysis
Blood Cells
Blood
Cells
Assays

Global architecture of the F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction

Shao, Y., Mann, J. M., Chen, W. & Fu, J., Mar 2014, In : Integrative Biology (United Kingdom). 6, 3, p. 300-311 12 p.

Research output: Contribution to journalArticle

Cell Shape
Endothelial cells
Actin Cytoskeleton
Actins
Endothelial Cells

Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells

Sun, Y., Yong, K. M. A., Villa-Diaz, L. G., Zhang, X., Chen, W., Philson, R., Weng, S., Xu, H., Krebsbach, P. H. & Fu, J., 2014, In : Nature Materials. 13, 6, p. 599-604 6 p.

Research output: Contribution to journalArticle

stem cells
Stem cells
neurons
rigidity
Rigidity

Integrated nanoplasmonic sensing for cellular functional immunoanalysis using human blood

Oh, B. R., Huang, N. T., Chen, W., Seo, J. H., Chen, P., Cornell, T. T., Shanley, T. P., Fu, J. & Kurabayashi, K., Mar 25 2014, In : ACS Nano. 8, 3, p. 2667-2676 10 p.

Research output: Contribution to journalArticle

Surface plasmon resonance
blood
Assays
Blood
surface plasmon resonance

Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the bottom

Chen, W., Shao, Y., Li, X., Zhao, G. & Fu, J., Dec 1 2014, In : Nano Today. 9, 6, p. 759-784 26 p.

Research output: Contribution to journalArticle

Biophysics
Stem cells
Stem Cells
Embryonic Development
Cellular Mechanotransduction
2013

Acoustic tweezing cytometry for live-cell subcellular modulation of intracellular cytoskeleton contractility

Fan, Z., Sun, Y., Di Chen, C., Tay, D., Chen, W., Deng, C. X. & Fu, J., 2013, In : Scientific Reports. 3, 2176.

Research output: Contribution to journalArticle

Cytoskeleton
Acoustics
Microbubbles
Actin Cytoskeleton
Ultrasonics

Adhesion strength-based, label-free isolation of human pluripotent stem cells

Singh, A., Suri, S., Lee, T., Chilton, J. M., Cooke, M. T., Chen, W., Fu, J., Stice, S. L., Lu, H., McDevitt, T. C. & García, A. J., May 2013, In : Nature Methods. 10, 5, p. 438-444 7 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Bond strength (materials)
Stem cells
Labels
Microfluidics

Emerging microfluidic tools for functional cellular immunophenotyping: A new potential paradigm for immune status characterization

Chen, W., Huang, N. T., Li, X., Yu, Z. T. F., Kurabayashi, K. & Fu, J., 2013, In : Frontiers in Oncology. 3 APR, Article 00098.

Research output: Contribution to journalArticle

Immunophenotyping
Microfluidics
Information Science
Immunologic Monitoring
Allergy and Immunology

Microfabricated nanotopological surfaces for study of adhesion-dependent cell mechanosensitivity

Chen, W., Sun, Y. & Fu, J., Jan 14 2013, In : Small. 9, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Cell Adhesion
Adhesion
Glass
Microtechnology
Cellular Microenvironment

Nanoroughened surfaces for efficient capture of circulating tumor cells without using capture antibodies

Chen, W., Weng, S., Zhang, F., Allen, S., Li, X., Bao, L., Lam, R. H. W., MacOska, J. A., Merajver, S. D. & Fu, J., Jan 22 2013, In : ACS Nano. 7, 1, p. 566-575 10 p.

Research output: Contribution to journalArticle

antibodies
Antibodies
Tumors
tumors
Cells

Surface-Micromachined Microfiltration Membranes for Efficient Isolation and Functional Immunophenotyping of Subpopulations of Immune Cells

Chen, W., Huang, N. T., Oh, B., Lam, R. H. W., Fan, R., Cornell, T. T., Shanley, T. P., Kurabayashi, K. & Fu, J., Jul 2013, In : Advanced healthcare materials. 2, 7, p. 965-975 11 p.

Research output: Contribution to journalArticle

Immunophenotyping
Microfiltration
Membranes
Cellular Immunity
Blood Cells
2012

An integrated microfluidic platform for in-situ cellular cytokine secretion immunophenotyping

Huang, N-T., Chen, W., Oh, B-R., Cornell, T. T., Shanley, T. P., Fu, J. & Kurabayashi, K., 2012, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 12, 20, p. 4093-4101

Research output: Contribution to journalArticle

Elastomeric microposts integrated into microfluidics for flow-mediated endothelial mechanotransduction analysis

Lam, R. H. W., Sun, Y., Chen, W. & Fu, J., Apr 24 2012, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 12, 10, p. 1865-1873 9 p.

Research output: Contribution to journalArticle

Microfluidics
Cellular Microenvironment
Rigidity
Endothelial cells
Adhesives

In silico experimentation of glioma microenvironment development and anti-tumor therapy

Wu, Y., Lu, Y., Chen, W., Fu, J. & Fan, R., Feb 2012, In : PLoS Computational Biology. 8, 2, e1002355.

Research output: Contribution to journalArticle

tumor
Glioma
Computer Simulation
Experimentation
Therapy

Mechanics regulates fate decisions of human embryonic stem cells

Sun, Y., Villa-Diaz, L. G., Lam, R. H. W., Chen, W., Krebsbach, P. H. & Fu, J., May 16 2012, In : PLoS One. 7, 5, e37178.

Research output: Contribution to journalArticle

embryonic stem cells
Stem cells
Mechanics
mechanics
cytoskeleton

Nanotopography influences adhesion, spreading, and self-renewal of Human embryonic stem cells

Chen, W., Villa-Diaz, L. G., Sun, Y., Weng, S., Kim, J. K., Lam, R. H. W., Han, L., Fan, R., Krebsbach, P. H. & Fu, J., May 22 2012, In : ACS Nano. 6, 5, p. 4094-4103 10 p.

Research output: Contribution to journalArticle

stem cells
Stem cells
adhesion
Adhesion
cells

Photolithographic surface micromachining of polydimethylsiloxane (PDMS)

Chen, W., Lam, R. H. W. & Fu, J., Jan 21 2012, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 12, 2, p. 391-395 5 p.

Research output: Contribution to journalArticle

Microtechnology
Surface micromachining
Polydimethylsiloxane
Photolithography
Microfiltration
2010

Fabrication and optical characterizations of smooth silver-silica nanocomposite films

Chen, W., Thoreson, M. D., Kildishev, A. V. & Shalaev, V. M., 2010, In : Laser Physics Letters. 7, 9, p. 677-684 8 p.

Research output: Contribution to journalArticle

Nanocomposite films
nanocomposites
Silver
silver
Silica

Toward superlensing with metal-dielectric composites and multilayers

Nielsen, R. B., Thoreson, M. D., Chen, W., Kristensen, A., Hvam, J. M., Shalaev, V. M. & Boltasseva, A., Jul 2010, In : Applied Physics B: Lasers and Optics. 100, 1, p. 93-100 8 p.

Research output: Contribution to journalArticle

composite materials
metals
near fields
permittivity
fabrication

Ultrathin, ultrasmooth, and low-loss silver films via wetting and annealing

Chen, W., Chen, K. P., Thoreson, M. D., Kildishev, A. V. & Shalaev, V. M., Nov 22 2010, In : Applied Physics Letters. 97, 21, 211107.

Research output: Contribution to journalArticle

wetting
silver
annealing
composite materials
temperature

Ultra-thin ultra-smooth and low-loss silver films on a germanium wetting layer

Chen, W., Thoreson, M. D., Ishii, S., Kildishev, A. V. & Shalaev, V. M., Mar 1 2010, In : Optics Express. 18, 5, p. 5124-5134 11 p.

Research output: Contribution to journalArticle

wetting
germanium
silver
annealing
surface roughness
2009

Broadband circularly polarized CPW-fed slot antenna array for millimeter wave application

Su, Z. J., Ding, G. F., Lu, W. J. & Chen, W., Aug 2009, In : Microelectronics Journal. 40, 8, p. 1192-1195 4 p.

Research output: Contribution to journalArticle

slot antennas
Slot antennas
antenna arrays
Antenna feeders
Antenna arrays
2008

Design and simulation of MEMS-based broadband unidirectional CPW-fed rectangular slot antenna

Chen, W., Ding, G. F., Li, B. H. & Sun, X. F., Mar 2008, In : Microsystem Technologies. 14, 3, p. 343-347 5 p.

Research output: Contribution to journalArticle

slot antennas
Slot antennas
Coplanar waveguides
Antenna feeders
antennas
Slot antennas
Antenna feeders
Antennas
Microfabrication
Studios
2007

A novel MEMS-based CPW-fed slot antenna for broadband circular polarization and unidirectional radiation

Chen, W., Ding, G., Su, Z. & Li, B., Nov 1 2007, In : Journal of Micromechanics and Microengineering. 17, 11, p. 2352-2359 8 p.

Research output: Contribution to journalArticle

slot antennas
Circular polarization
Slot antennas
Antenna feeders
circular polarization

CPW-fed bow-tie slot-coupled millimeter wave patch antenna

Gu, D. H., Ding, G. F., Chen, W., Sun, X. F., Shen, M. Y. & Li, B. H., Oct 2007, In : Dianzi Yu Xinxi Xuebao/Journal of Electronics and Information Technology. 29, 10, p. 2392-2395 4 p.

Research output: Contribution to journalArticle

Antenna feeders
Microstrip antennas
Millimeter waves
Antennas
Bandwidth

Design, simulation and characterization of an inertia micro-switch fabricated by non-silicon surface micromachining

Yang, Z., Ding, G., Chen, W., Fu, S., Sun, X. & Zhao, X., Aug 1 2007, In : Journal of Micromechanics and Microengineering. 17, 8, p. 1598-1604 7 p., 024.

Research output: Contribution to journalArticle

Surface micromachining
micromachining
inertia
switches
Switches