Photo of Weiqiang Chen

Weiqiang Chen

Assistant Professor

    20062019
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    Research Output 2006 2019

    Article

    Acoustic tweezing cytometry for live-cell subcellular modulation of intracellular cytoskeleton contractility

    Fan, Z., Sun, Y., Di Chen, C., Tay, D., Chen, W., Deng, C. X. & Fu, J., 2013, In : Scientific Reports. 3, 2176.

    Research output: Contribution to journalArticle

    Cytoskeleton
    Acoustics
    Microbubbles
    Actin Cytoskeleton
    Ultrasonics

    Adhesion strength-based, label-free isolation of human pluripotent stem cells

    Singh, A., Suri, S., Lee, T., Chilton, J. M., Cooke, M. T., Chen, W., Fu, J., Stice, S. L., Lu, H., McDevitt, T. C. & García, A. J., May 2013, In : Nature Methods. 10, 5, p. 438-444 7 p.

    Research output: Contribution to journalArticle

    Pluripotent Stem Cells
    Bond strength (materials)
    Stem cells
    Labels
    Microfluidics

    A fluorescent microbead-based microfluidic immunoassay chip for immune cell cytokine secretion quantification

    Cui, X., Liu, Y., Hu, D., Qian, W., Tin, C., Sun, D., Chen, W. & Lam, R. H. W., Jan 1 2018, In : Lab on a Chip. 18, 3, p. 522-531 10 p.

    Research output: Contribution to journalArticle

    Microfluidics
    Microspheres
    Immunoassay
    Cytokines
    Lab-On-A-Chip Devices

    An integrated adipose-tissue-on-chip nanoplasmonic biosensing platform for investigating obesity-associated inflammation

    Zhu, J., He, J., Verano, M., Brimmo, A. T., Glia, A., Qasaimeh, M., Chen, P., Aleman, J. O. & Chen, W., Dec 7 2018, In : Lab on a Chip. 18, 23, p. 3550-3560 11 p.

    Research output: Contribution to journalArticle

    Adipose Tissue
    Obesity
    Tissue
    Cytokines
    Inflammation

    An integrated microfluidic platform for in-situ cellular cytokine secretion immunophenotyping

    Huang, N-T., Chen, W., Oh, B-R., Cornell, T. T., Shanley, T. P., Fu, J. & Kurabayashi, K., 2012, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 12, 20, p. 4093-4101

    Research output: Contribution to journalArticle

    A novel MEMS-based CPW-fed slot antenna for broadband circular polarization and unidirectional radiation

    Chen, W., Ding, G., Su, Z. & Li, B., Nov 1 2007, In : Journal of Micromechanics and Microengineering. 17, 11, p. 2352-2359 8 p.

    Research output: Contribution to journalArticle

    slot antennas
    Circular polarization
    Slot antennas
    Antenna feeders
    circular polarization

    A Photoresponsive Hyaluronan Hydrogel Nanocomposite for Dynamic Macrophage Immunomodulation

    Wang, H., Morales, R. T. T., Cui, X., Huang, J., Qian, W., Tong, J. & Chen, W., Jan 1 2018, (Accepted/In press) In : Advanced healthcare materials. 1801234.

    Research output: Contribution to journalArticle

    Nanocomposites
    Immunomodulation
    Macrophages
    Hydrogel
    Hyaluronic Acid

    Biophysical Phenotyping and Modulation of ALDH+ Inflammatory Breast Cancer Stem-Like Cells

    Chen, W., Allen, S. G., Qian, W., Peng, Z., Han, S., Li, X., Sun, Y., Fournier, C., Bao, L., Lam, R. H. W., Merajver, S. D. & Fu, J., Jan 1 2019, (Accepted/In press) In : Small. 1802891.

    Research output: Contribution to journalArticle

    Inflammatory Breast Neoplasms
    Neoplastic Stem Cells
    Modulation
    Bond strength (materials)
    Formability

    Broadband circularly polarized CPW-fed slot antenna array for millimeter wave application

    Su, Z. J., Ding, G. F., Lu, W. J. & Chen, W., Aug 2009, In : Microelectronics Journal. 40, 8, p. 1192-1195 4 p.

    Research output: Contribution to journalArticle

    slot antennas
    Slot antennas
    antenna arrays
    Antenna feeders
    Antenna arrays

    Capturing Cancer: Emerging Microfluidic Technologies for the Capture and Characterization of Circulating Tumor Cells

    Qian, W., Zhang, Y. & Chen, W., Aug 1 2015, In : Small. 11, 32, p. 3850-3872 23 p.

    Research output: Contribution to journalArticle

    Circulating Neoplastic Cells
    Microfluidics
    Tumors
    Cells
    Technology

    Cellogram: On-the-Fly Traction Force Microscopy

    Lendenmann, T., Schneider, T., Dumas, J., Tarini, M., Giampietro, C., Bajpai, A., Chen, W., Gerber, J., Poulikakos, D., Ferrari, A. & Panozzo, D., Oct 9 2019, In : Nano Letters. 19, 10, p. 6742-6750 9 p.

    Research output: Contribution to journalArticle

    traction
    Microscopic examination
    microscopy
    Image processing
    Cells

    Continuous-flow microfluidic blood cell sorting for unprocessed whole blood using surface-micromachined microfiltration membranes

    Li, X., Chen, W., Liu, G., Lu, W. & Fu, J., Jul 21 2014, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 14, 14, p. 2565-2575 11 p.

    Research output: Contribution to journalArticle

    Microfiltration
    Microfluidics
    Sorting
    Blood Cells
    Blood

    CPW-fed bow-tie slot-coupled millimeter wave patch antenna

    Gu, D. H., Ding, G. F., Chen, W., Sun, X. F., Shen, M. Y. & Li, B. H., Oct 2007, In : Dianzi Yu Xinxi Xuebao/Journal of Electronics and Information Technology. 29, 10, p. 2392-2395 4 p.

    Research output: Contribution to journalArticle

    Antenna feeders
    Microstrip antennas
    Millimeter waves
    Antennas
    Bandwidth

    Design, simulation and characterization of an inertia micro-switch fabricated by non-silicon surface micromachining

    Yang, Z., Ding, G., Chen, W., Fu, S., Sun, X. & Zhao, X., Aug 1 2007, In : Journal of Micromechanics and Microengineering. 17, 8, p. 1598-1604 7 p., 024.

    Research output: Contribution to journalArticle

    Surface micromachining
    micromachining
    inertia
    switches
    Switches

    Design and simulation of MEMS-based broadband unidirectional CPW-fed rectangular slot antenna

    Chen, W., Ding, G. F., Li, B. H. & Sun, X. F., Mar 2008, In : Microsystem Technologies. 14, 3, p. 343-347 5 p.

    Research output: Contribution to journalArticle

    slot antennas
    Slot antennas
    Coplanar waveguides
    Antenna feeders
    antennas
    Slot antennas
    Antenna feeders
    Antennas
    Microfabrication
    Studios

    Elastomeric microposts integrated into microfluidics for flow-mediated endothelial mechanotransduction analysis

    Lam, R. H. W., Sun, Y., Chen, W. & Fu, J., Apr 24 2012, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 12, 10, p. 1865-1873 9 p.

    Research output: Contribution to journalArticle

    Microfluidics
    Cellular Microenvironment
    Rigidity
    Endothelial cells
    Adhesives

    Emerging microengineered tools for functional analysis and phenotyping of blood cells

    Li, X., Chen, W., Li, Z., Li, L., Gu, H. & Fu, J., Nov 1 2014, In : Trends in Biotechnology. 32, 11, p. 586-594 9 p.

    Research output: Contribution to journalArticle

    Functional analysis
    Blood Cells
    Blood
    Cells
    Assays

    Emerging microfluidic tools for functional cellular immunophenotyping: A new potential paradigm for immune status characterization

    Chen, W., Huang, N. T., Li, X., Yu, Z. T. F., Kurabayashi, K. & Fu, J., 2013, In : Frontiers in Oncology. 3 APR, Article 00098.

    Research output: Contribution to journalArticle

    Immunophenotyping
    Microfluidics
    Information Science
    Immunologic Monitoring
    Allergy and Immunology

    Energy-Mediated Machinery Drives Cellular Mechanical Allostasis

    Wang, Q., Qian, W., Xu, X., Bajpai, A., Guan, K., Zhang, Z., Chen, R., Flamini, V. & Chen, W., Jan 1 2019, In : Advanced Materials. 1900453.

    Research output: Contribution to journalArticle

    Machinery
    Mechanics
    Energy barriers
    Stabilization
    Aging of materials

    Engineering Nanoscale Stem Cell Niche: Direct Stem Cell Behavior at Cell-Matrix Interface

    Zhang, Y., Gordon, A., Qian, W. & Chen, W., Sep 1 2015, In : Advanced healthcare materials. 4, 13, p. 1900-1914 15 p.

    Research output: Contribution to journalArticle

    Stem Cell Niche
    Stem cells
    Stem Cells
    Cues
    Regenerative Medicine

    Fabrication and optical characterizations of smooth silver-silica nanocomposite films

    Chen, W., Thoreson, M. D., Kildishev, A. V. & Shalaev, V. M., 2010, In : Laser Physics Letters. 7, 9, p. 677-684 8 p.

    Research output: Contribution to journalArticle

    Nanocomposite films
    nanocomposites
    Silver
    silver
    Silica

    Global architecture of the F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction

    Shao, Y., Mann, J. M., Chen, W. & Fu, J., Mar 2014, In : Integrative Biology (United Kingdom). 6, 3, p. 300-311 12 p.

    Research output: Contribution to journalArticle

    Cell Shape
    Endothelial cells
    Actin Cytoskeleton
    Actins
    Endothelial Cells

    Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis

    Cui, X., Morales, R. T. T., Qian, W., Wang, H., Gagner, J. P., Dolgalev, I., Placantonakis, D., Zagzag, D., Cimmino, L., Snuderl, M., Lam, R. H. W. & Chen, W., Apr 1 2018, In : Biomaterials. 161, p. 164-178 15 p.

    Research output: Contribution to journalArticle

    Macrophages
    Glioblastoma
    Immunosuppression
    Tumors
    Immunosuppressive Agents

    Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells

    Sun, Y., Yong, K. M. A., Villa-Diaz, L. G., Zhang, X., Chen, W., Philson, R., Weng, S., Xu, H., Krebsbach, P. H. & Fu, J., 2014, In : Nature Materials. 13, 6, p. 599-604 6 p.

    Research output: Contribution to journalArticle

    stem cells
    Stem cells
    neurons
    rigidity
    Rigidity

    In silico experimentation of glioma microenvironment development and anti-tumor therapy

    Wu, Y., Lu, Y., Chen, W., Fu, J. & Fan, R., Feb 2012, In : PLoS Computational Biology. 8, 2, e1002355.

    Research output: Contribution to journalArticle

    tumor
    Glioma
    Computer Simulation
    Experimentation
    Therapy

    Integrated nanoplasmonic sensing for cellular functional immunoanalysis using human blood

    Oh, B. R., Huang, N. T., Chen, W., Seo, J. H., Chen, P., Cornell, T. T., Shanley, T. P., Fu, J. & Kurabayashi, K., Mar 25 2014, In : ACS Nano. 8, 3, p. 2667-2676 10 p.

    Research output: Contribution to journalArticle

    Surface plasmon resonance
    blood
    Assays
    Blood
    surface plasmon resonance

    Magnet Patterned Superparamagnetic Fe3O4/Au Core–Shell Nanoplasmonic Sensing Array for Label-Free High Throughput Cytokine Immunoassay

    Cai, Y., Zhu, J., He, J., Yang, W., Ma, C., Xiong, F., Li, F., Chen, W. & Chen, P., Jan 1 2019, (Accepted/In press) In : Advanced healthcare materials. 1801478.

    Research output: Contribution to journalArticle

    Magnets
    Microarrays
    Immunoassay
    Labels
    Immunologic Monitoring

    Mechanics regulates fate decisions of human embryonic stem cells

    Sun, Y., Villa-Diaz, L. G., Lam, R. H. W., Chen, W., Krebsbach, P. H. & Fu, J., May 16 2012, In : PLoS One. 7, 5, e37178.

    Research output: Contribution to journalArticle

    embryonic stem cells
    Stem cells
    Mechanics
    mechanics
    cytoskeleton

    Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis

    Weng, S., Shao, Y., Chen, W. & Fu, J., May 30 2016, (Accepted/In press) In : Nature Materials.

    Research output: Contribution to journalArticle

    homeostasis
    adhesion
    Adhesion
    cells
    Integrins

    Microfabricated nanotopological surfaces for study of adhesion-dependent cell mechanosensitivity

    Chen, W., Sun, Y. & Fu, J., Jan 14 2013, In : Small. 9, 1, p. 81-89 9 p.

    Research output: Contribution to journalArticle

    Cell Adhesion
    Adhesion
    Glass
    Microtechnology
    Cellular Microenvironment

    Multiparametric Biomechanical and Biochemical Phenotypic Profiling of Single Cancer Cells Using an Elasticity Microcytometer

    Hu, S., Liu, G., Chen, W., Li, X., Lu, W., Lam, R. H. W. & Fu, J., 2016, (Accepted/In press) In : Small.

    Research output: Contribution to journalArticle

    Elasticity
    Cells
    Neoplasms
    Formability
    Microfluidics

    Nanoroughened adhesion-based capture of circulating tumor cells with heterogeneous expression and metastatic characteristics

    Chen, W., Allen, S. G., Reka, A. K., Qian, W., Han, S., Zhao, J., Bao, L., Keshamouni, V. G., Merajver, S. D. & Fu, J., Aug 8 2016, In : BMC Cancer. 16, 1, 614.

    Research output: Contribution to journalArticle

    Circulating Neoplastic Cells
    Microfluidics
    Glass
    Neoplasms
    Lung Neoplasms

    Nanoroughened surfaces for efficient capture of circulating tumor cells without using capture antibodies

    Chen, W., Weng, S., Zhang, F., Allen, S., Li, X., Bao, L., Lam, R. H. W., MacOska, J. A., Merajver, S. D. & Fu, J., Jan 22 2013, In : ACS Nano. 7, 1, p. 566-575 10 p.

    Research output: Contribution to journalArticle

    antibodies
    Antibodies
    Tumors
    tumors
    Cells

    Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the bottom

    Chen, W., Shao, Y., Li, X., Zhao, G. & Fu, J., Dec 1 2014, In : Nano Today. 9, 6, p. 759-784 26 p.

    Research output: Contribution to journalArticle

    Biophysics
    Stem cells
    Stem Cells
    Embryonic Development
    Cellular Mechanotransduction

    Nanotopographic Biomaterials for Isolation of Circulating Tumor Cells

    Qian, W., Zhang, Y., Gordon, A. & Chen, W., Nov 1 2015, In : Journal of Nanotechnology in Engineering and Medicine. 5, 4, 040802.

    Research output: Contribution to journalArticle

    Circulating Neoplastic Cells
    Biocompatible Materials
    Biomaterials
    Tumors
    Cells

    Nanotopographic Regulation of Human Mesenchymal Stem Cell Osteogenesis

    Qian, W., Gong, L., Cui, X., Zhang, Z., Bajpai, A., Liu, C., Castillo, A., Teo, J. & Chen, W., Dec 6 2017, In : ACS Applied Materials and Interfaces. 9, 48, p. 41794-41806 13 p.

    Research output: Contribution to journalArticle

    Stem cells
    Dexamethasone
    Modulators
    Bone
    Adhesion

    Nanotopography influences adhesion, spreading, and self-renewal of Human embryonic stem cells

    Chen, W., Villa-Diaz, L. G., Sun, Y., Weng, S., Kim, J. K., Lam, R. H. W., Han, L., Fan, R., Krebsbach, P. H. & Fu, J., May 22 2012, In : ACS Nano. 6, 5, p. 4094-4103 10 p.

    Research output: Contribution to journalArticle

    stem cells
    Stem cells
    adhesion
    Adhesion
    cells

    Nanotopography regulates motor neuron differentiation of human pluripotent stem cells

    Chen, W., Han, S., Qian, W., Weng, S., Yang, H., Sun, Y., Villa-Diaz, L. G., Krebsbach, P. H. & Fu, J., Feb 21 2018, In : Nanoscale. 10, 7, p. 3556-3565 10 p.

    Research output: Contribution to journalArticle

    Stem cells
    Neurons
    Actomyosin
    Cell adhesion
    Reactive ion etching

    Osteoblast-derived paracrine factors regulate angiogenesis in response to mechanical stimulation

    Liu, C., Cui, X., Ackermann, T. M., Flamini, V., Chen, W. & Castillo, A., Jul 1 2016, In : Integrative Biology (United Kingdom). 8, 7, p. 785-794 10 p.

    Research output: Contribution to journalArticle

    Angiogenesis Inducing Agents
    Osteoblasts
    Endothelial cells
    Conditioned Culture Medium
    Endothelial Cells

    Photolithographic surface micromachining of polydimethylsiloxane (PDMS)

    Chen, W., Lam, R. H. W. & Fu, J., Jan 21 2012, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 12, 2, p. 391-395 5 p.

    Research output: Contribution to journalArticle

    Microtechnology
    Surface micromachining
    Polydimethylsiloxane
    Photolithography
    Microfiltration

    Probing Single-Cell Mechanical Allostasis Using Ultrasound Tweezers

    Qian, W. & Chen, W., Jan 1 2019, In : Cellular and Molecular Bioengineering.

    Research output: Contribution to journalArticle

    Allostasis
    Actomyosin
    Ultrasound
    Ultrasonics
    Medical problems

    Surface-Micromachined Microfiltration Membranes for Efficient Isolation and Functional Immunophenotyping of Subpopulations of Immune Cells

    Chen, W., Huang, N. T., Oh, B., Lam, R. H. W., Fan, R., Cornell, T. T., Shanley, T. P., Kurabayashi, K. & Fu, J., Jul 2013, In : Advanced healthcare materials. 2, 7, p. 965-975 11 p.

    Research output: Contribution to journalArticle

    Immunophenotyping
    Microfiltration
    Membranes
    Cellular Immunity
    Blood Cells

    Surface micromachining of polydimethylsiloxane for microfluidics applications

    Hill, S., Qian, W., Chen, W. & Fu, J., Sep 1 2016, In : Biomicrofluidics. 10, 5, 054114.

    Research output: Contribution to journalArticle

    Microtechnology
    Surface micromachining
    Microfluidics
    Polydimethylsiloxane
    micromachining

    The Interplay Between Cell-Cell and Cell-Matrix Forces Regulates Cell Migration Dynamics

    Bajpai, A., Tong, J., Qian, W., Peng, Y. & Chen, W., Nov 19 2019, In : Biophysical Journal. 117, 10, p. 1795-1804 10 p.

    Research output: Contribution to journalArticle

    Cell Movement
    Traction
    Extracellular Matrix
    Wound Healing
    Embryonic Development

    Toward superlensing with metal-dielectric composites and multilayers

    Nielsen, R. B., Thoreson, M. D., Chen, W., Kristensen, A., Hvam, J. M., Shalaev, V. M. & Boltasseva, A., Jul 2010, In : Applied Physics B: Lasers and Optics. 100, 1, p. 93-100 8 p.

    Research output: Contribution to journalArticle

    composite materials
    metals
    near fields
    permittivity
    fabrication

    Ultrathin, ultrasmooth, and low-loss silver films via wetting and annealing

    Chen, W., Chen, K. P., Thoreson, M. D., Kildishev, A. V. & Shalaev, V. M., Nov 22 2010, In : Applied Physics Letters. 97, 21, 211107.

    Research output: Contribution to journalArticle

    wetting
    silver
    annealing
    composite materials
    temperature

    Ultra-thin ultra-smooth and low-loss silver films on a germanium wetting layer

    Chen, W., Thoreson, M. D., Ishii, S., Kildishev, A. V. & Shalaev, V. M., Mar 1 2010, In : Optics Express. 18, 5, p. 5124-5134 11 p.

    Research output: Contribution to journalArticle

    wetting
    germanium
    silver
    annealing
    surface roughness
    Conference contribution

    An integrated microfluidic platform for in-situ cellular cytokine secretion immunophenotyping

    Huang, N. T., Chen, W., Oh, B. R., Fu, J. & Kurabayashi, K., 2012, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, p. 989-991 3 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Microfluidics
    Assays
    Cytokines
    Immunosorbents
    Chemiluminescence

    Capture circulating tumor cells on glass

    Chen, W., Weng, S., Allen, S., Merajver, S. D. & Fu, J., 2013, The 2013 University of Michigan Annual Symposium of the Microfluidics in Biomedical Sciences Training Program, Ann Arbor, MI, May 2013.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution