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Weiqiang Chen

Assistant Professor

    20062019
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    Research Output 2006 2019

    Ultra-thin ultra-smooth and low-loss silver films on a germanium wetting layer

    Chen, W., Thoreson, M. D., Ishii, S., Kildishev, A. V. & Shalaev, V. M., Mar 1 2010, In : Optics Express. 18, 5, p. 5124-5134 11 p.

    Research output: Contribution to journalArticle

    wetting
    germanium
    silver
    annealing
    surface roughness

    Ultra-thin ultra-smooth and low-loss silver and silver-silica composite films for superlensing applications

    Chen, W., Thoreson, M. D., Kildishev, A. V. & Shalaev, V. M., 2010, Quantum Electronics and Laser Science Conference, QELS 2010.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Composite films
    Silver
    silver
    Silica
    silicon dioxide

    Ultra-thin ultra-smooth and low-loss silver and silverSilica composite films for superlensing applications

    Chen, W., Thoreson, M. D., Kildishev, A. V. & Shalaev, V. M., 2010, Lasers and Electro-Optics/Quantum Electronics and Laser Science Conference: 2010 Laser Science to Photonic Applications, CLEO/QELS 2010. 5500781

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Composite films
    Silver
    silver
    composite materials
    Germanium

    Ultrathin, ultrasmooth, and low-loss silver films via wetting and annealing

    Chen, W., Chen, K. P., Thoreson, M. D., Kildishev, A. V. & Shalaev, V. M., Nov 22 2010, In : Applied Physics Letters. 97, 21, 211107.

    Research output: Contribution to journalArticle

    wetting
    silver
    annealing
    composite materials
    temperature

    Toward superlensing with metal-dielectric composites and multilayers

    Nielsen, R. B., Thoreson, M. D., Chen, W., Kristensen, A., Hvam, J. M., Shalaev, V. M. & Boltasseva, A., Jul 2010, In : Applied Physics B: Lasers and Optics. 100, 1, p. 93-100 8 p.

    Research output: Contribution to journalArticle

    composite materials
    metals
    near fields
    permittivity
    fabrication

    The Interplay Between Cell-Cell and Cell-Matrix Forces Regulates Cell Migration Dynamics

    Bajpai, A., Tong, J., Qian, W., Peng, Y. & Chen, W., Nov 19 2019, In : Biophysical Journal. 117, 10, p. 1795-1804 10 p.

    Research output: Contribution to journalArticle

    Cell Movement
    Traction
    Extracellular Matrix
    Wound Healing
    Embryonic Development

    Surface micromachining of polydimethylsiloxane for microfluidics applications

    Hill, S., Qian, W., Chen, W. & Fu, J., Sep 1 2016, In : Biomicrofluidics. 10, 5, 054114.

    Research output: Contribution to journalArticle

    Microtechnology
    Surface micromachining
    Microfluidics
    Polydimethylsiloxane
    micromachining

    Surface micromachining of polydimethylsiloxane (PDMS) for microfluidic biomedical applications

    Chen, W., Huang, N. T., Kurabayashi, K. & Fu, J., 2012, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, p. 1849-1851 3 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Surface micromachining
    Polydimethylsiloxane
    Microfluidics
    Photolithography
    Microfiltration

    Surface-Micromachined Microfiltration Membranes for Efficient Isolation and Functional Immunophenotyping of Subpopulations of Immune Cells

    Chen, W., Huang, N. T., Oh, B., Lam, R. H. W., Fan, R., Cornell, T. T., Shanley, T. P., Kurabayashi, K. & Fu, J., Jul 2013, In : Advanced healthcare materials. 2, 7, p. 965-975 11 p.

    Research output: Contribution to journalArticle

    Immunophenotyping
    Microfiltration
    Membranes
    Cellular Immunity
    Blood Cells

    Special Issue: Bio-Interfaces for Immunoengineering

    Chen, W. & Kim, D. H., Feb 21 2019, In : Advanced Healthcare Materials. 8, 4, 1900098.

    Research output: Contribution to journalEditorial

    Probing Single-Cell Mechanical Allostasis Using Ultrasound Tweezers

    Qian, W. & Chen, W., Jan 1 2019, In : Cellular and Molecular Bioengineering.

    Research output: Contribution to journalArticle

    Allostasis
    Actomyosin
    Ultrasound
    Ultrasonics
    Medical problems

    Photolithographic surface micromachining of polydimethylsiloxane (PDMS)

    Chen, W., Lam, R. H. W. & Fu, J., Jan 21 2012, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 12, 2, p. 391-395 5 p.

    Research output: Contribution to journalArticle

    Microtechnology
    Surface micromachining
    Polydimethylsiloxane
    Photolithography
    Microfiltration

    Osteoblast-derived paracrine factors regulate angiogenesis in response to mechanical stimulation

    Liu, C., Cui, X., Ackermann, T. M., Flamini, V., Chen, W. & Castillo, A., Jul 1 2016, In : Integrative Biology (United Kingdom). 8, 7, p. 785-794 10 p.

    Research output: Contribution to journalArticle

    Angiogenesis Inducing Agents
    Osteoblasts
    Endothelial cells
    Conditioned Culture Medium
    Endothelial Cells

    Nanotopography regulates motor neuron differentiation of human pluripotent stem cells

    Chen, W., Han, S., Qian, W., Weng, S., Yang, H., Sun, Y., Villa-Diaz, L. G., Krebsbach, P. H. & Fu, J., Feb 21 2018, In : Nanoscale. 10, 7, p. 3556-3565 10 p.

    Research output: Contribution to journalArticle

    Stem cells
    Neurons
    Actomyosin
    Cell adhesion
    Reactive ion etching

    Nanotopography mediate functional responses of human embryonic stem cells

    Chen, W., Villa-Diaz, L. G., Sun, Y., Weng, S., Krebsbach, P. H. & Fu, J., 2012, Biomedical Engineering Society Annual Meeting (BMES 2012), Atlanta, Georgia, October 2012.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Nanotopography influences adhesion, spreading, and self-renewal of Human embryonic stem cells

    Chen, W., Villa-Diaz, L. G., Sun, Y., Weng, S., Kim, J. K., Lam, R. H. W., Han, L., Fan, R., Krebsbach, P. H. & Fu, J., May 22 2012, In : ACS Nano. 6, 5, p. 4094-4103 10 p.

    Research output: Contribution to journalArticle

    stem cells
    Stem cells
    adhesion
    Adhesion
    cells

    Nanotopography directs fate of human embryonic stem cells

    Chen, W., Villa-Diaz, L. G., Sun, Y., Weng, S., Kim, J. K., Krebsbach, P. H. & Fu, J., 2012, ASME 2012 Summer Bioengineering Conference, SBC 2012. p. 1293-1294 2 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Stem cells

    Nanotopography-based circular tumor cell capture

    Chen, W., Weng, S. & Fu, J., 2012, The 4th Annual Michigan Graduate Academic Conference, East Lansing, MI, May 2012.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Nanotopographic surface for efficient capture of circulating tumor cells

    Chen, W., Weng, S. & Fu, J., 2013, Proceedings of the ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology (NEMB 2013), Boston, MA, February 2013.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Nanotopographic Regulation of Human Mesenchymal Stem Cell Osteogenesis

    Qian, W., Gong, L., Cui, X., Zhang, Z., Bajpai, A., Liu, C., Castillo, A., Teo, J. & Chen, W., Dec 6 2017, In : ACS Applied Materials and Interfaces. 9, 48, p. 41794-41806 13 p.

    Research output: Contribution to journalArticle

    Stem cells
    Dexamethasone
    Modulators
    Bone
    Adhesion

    Nanotopographic control of human embryonic stem cell function

    Chen, W., Sun, Y. & Fu, J., 2011, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 1. p. 36-38 3 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Stem cells
    Reactive ion etching
    Photolithography
    Glass
    Substrates

    Nanotopographic Biomaterials for Isolation of Circulating Tumor Cells

    Qian, W., Zhang, Y., Gordon, A. & Chen, W., Nov 1 2015, In : Journal of Nanotechnology in Engineering and Medicine. 5, 4, 040802.

    Research output: Contribution to journalArticle

    Circulating Neoplastic Cells
    Biocompatible Materials
    Biomaterials
    Tumors
    Cells

    Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the bottom

    Chen, W., Shao, Y., Li, X., Zhao, G. & Fu, J., Dec 1 2014, In : Nano Today. 9, 6, p. 759-784 26 p.

    Research output: Contribution to journalArticle

    Biophysics
    Stem cells
    Stem Cells
    Embryonic Development
    Cellular Mechanotransduction

    Nano scale sensitivity at cell-substrate interface

    Chen, W., Sun, Y. & Fu, J., 2011, The 2011 University of Michigan Annual Symposium of the Microfluidics in Biomedical Sciences Training Program, Ann Arbor, MI, May 2011.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Nanoroughened surfaces for efficient capture of circulating tumor cells without using capture antibodies

    Chen, W., Weng, S., Zhang, F., Allen, S., Li, X., Bao, L., Lam, R. H. W., MacOska, J. A., Merajver, S. D. & Fu, J., Jan 22 2013, In : ACS Nano. 7, 1, p. 566-575 10 p.

    Research output: Contribution to journalArticle

    antibodies
    Antibodies
    Tumors
    tumors
    Cells

    Nanoroughened adhesion-based capture of circulating tumor cells with heterogeneous expression and metastatic characteristics

    Chen, W., Allen, S. G., Reka, A. K., Qian, W., Han, S., Zhao, J., Bao, L., Keshamouni, V. G., Merajver, S. D. & Fu, J., Aug 8 2016, In : BMC Cancer. 16, 1, 614.

    Research output: Contribution to journalArticle

    Circulating Neoplastic Cells
    Microfluidics
    Glass
    Neoplasms
    Lung Neoplasms

    Multiparametric Biomechanical and Biochemical Phenotypic Profiling of Single Cancer Cells Using an Elasticity Microcytometer

    Hu, S., Liu, G., Chen, W., Li, X., Lu, W., Lam, R. H. W. & Fu, J., 2016, (Accepted/In press) In : Small.

    Research output: Contribution to journalArticle

    Elasticity
    Cells
    Neoplasms
    Formability
    Microfluidics

    Micromechanical elastomeric devices for investigations of mechanobiology in human embryonic stem cells

    Sun, Y., Villa-Diaz, L. G., Lam, R. H. W., Chen, W., Krebsbach, P. H. & Fu, J., 2012, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, p. 1714-1716 3 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Stem cells
    elastomeric
    Cadherins
    Rigidity
    Mechanics

    Microfluidic immunophenotyping assay platform for immunomonitoring of subpopulations of immune cells

    Chen, W., Huang, N., Oh, B., Cornell, T. T., Shanley, T. P., Kurabayashi, K. & Fu, J., 2013, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society, Vol. 3. p. 1761-1763 3 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Microfluidics
    Assays
    Immune system
    Blood

    Microfabricated nanotopological surfaces for study of adhesion-dependent cell mechanosensitivity

    Chen, W., Sun, Y. & Fu, J., Jan 14 2013, In : Small. 9, 1, p. 81-89 9 p.

    Research output: Contribution to journalArticle

    Cell Adhesion
    Adhesion
    Glass
    Microtechnology
    Cellular Microenvironment

    Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis

    Weng, S., Shao, Y., Chen, W. & Fu, J., May 30 2016, (Accepted/In press) In : Nature Materials.

    Research output: Contribution to journalArticle

    homeostasis
    adhesion
    Adhesion
    cells
    Integrins

    Mechanics regulates fate decisions of human embryonic stem cells

    Sun, Y., Villa-Diaz, L. G., Lam, R. H. W., Chen, W., Krebsbach, P. H. & Fu, J., May 16 2012, In : PLoS One. 7, 5, e37178.

    Research output: Contribution to journalArticle

    embryonic stem cells
    Stem cells
    Mechanics
    mechanics
    cytoskeleton

    Magnet Patterned Superparamagnetic Fe3O4/Au Core–Shell Nanoplasmonic Sensing Array for Label-Free High Throughput Cytokine Immunoassay

    Cai, Y., Zhu, J., He, J., Yang, W., Ma, C., Xiong, F., Li, F., Chen, W. & Chen, P., Jan 1 2019, (Accepted/In press) In : Advanced healthcare materials. 1801478.

    Research output: Contribution to journalArticle

    Magnets
    Microarrays
    Immunoassay
    Labels
    Immunologic Monitoring

    Localized surface plasmon resonance (LSPR) optofluidic biosensor for label-free cellular immunophenotyping

    Oh, B. R., Huang, N. T., Chen, W., Seo, J., Fu, J. & Kurabayashi, K., 2013, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society, Vol. 1. p. 92-94 3 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Surface plasmon resonance
    Biosensors
    Labels
    Cytokines
    Microfluidics

    Investigation of mechanoresponsive behaviors of human embryonic stem cells using microfabricated elastomeric post arrays

    Sun, Y., Villa-Diaz, L. G., Lam, R. H. W., Chen, W., Krebsbach, P. H. & Fu, J., 2012, ASME 2012 Summer Bioengineering Conference, SBC 2012. p. 317-318 2 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Stem cells

    Integrated nanoplasmonic sensing for cellular functional immunoanalysis using human blood

    Oh, B. R., Huang, N. T., Chen, W., Seo, J. H., Chen, P., Cornell, T. T., Shanley, T. P., Fu, J. & Kurabayashi, K., Mar 25 2014, In : ACS Nano. 8, 3, p. 2667-2676 10 p.

    Research output: Contribution to journalArticle

    Surface plasmon resonance
    blood
    Assays
    Blood
    surface plasmon resonance

    Integrated microfluidic platform for efficient isolation and functional immunophenotyping of subpopulations of immune cells

    Chen, W., Huang, N., Oh, B., Kurabayashi, K. & Fu, J., 2013, Proceedings of the ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology (NEMB 2013), Boston, MA, February 2013.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Integrated microfluidic chip for efficient isolation and functional immunophenotyping of subpopulations of immune cells

    Chen, W., Huang, N., Oh, B., Cornell, T. T., Shanley, T. P., Kurabayashi, K. & Fu, J., 2012, The 2012 University of Michigan Engineering Graduate Sympousium, Ann Arbor, MI, November 2012.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    In silico experimentation of glioma microenvironment development and anti-tumor therapy

    Wu, Y., Lu, Y., Chen, W., Fu, J. & Fan, R., Feb 2012, In : PLoS Computational Biology. 8, 2, e1002355.

    Research output: Contribution to journalArticle

    tumor
    Glioma
    Computer Simulation
    Experimentation
    Therapy

    Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells

    Sun, Y., Yong, K. M. A., Villa-Diaz, L. G., Zhang, X., Chen, W., Philson, R., Weng, S., Xu, H., Krebsbach, P. H. & Fu, J., 2014, In : Nature Materials. 13, 6, p. 599-604 6 p.

    Research output: Contribution to journalArticle

    stem cells
    Stem cells
    neurons
    rigidity
    Rigidity

    Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis

    Cui, X., Morales, R. T. T., Qian, W., Wang, H., Gagner, J. P., Dolgalev, I., Placantonakis, D., Zagzag, D., Cimmino, L., Snuderl, M., Lam, R. H. W. & Chen, W., Apr 1 2018, In : Biomaterials. 161, p. 164-178 15 p.

    Research output: Contribution to journalArticle

    Macrophages
    Glioblastoma
    Immunosuppression
    Tumors
    Immunosuppressive Agents

    Global architecture of the F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction

    Shao, Y., Mann, J. M., Chen, W. & Fu, J., Mar 2014, In : Integrative Biology (United Kingdom). 6, 3, p. 300-311 12 p.

    Research output: Contribution to journalArticle

    Cell Shape
    Endothelial cells
    Actin Cytoskeleton
    Actins
    Endothelial Cells

    Fabrication and optical characterizations of smooth silver-silica nanocomposite films

    Chen, W., Thoreson, M. D., Kildishev, A. V. & Shalaev, V. M., 2010, In : Laser Physics Letters. 7, 9, p. 677-684 8 p.

    Research output: Contribution to journalArticle

    Nanocomposite films
    nanocomposites
    Silver
    silver
    Silica

    Engineering Nanoscale Stem Cell Niche: Direct Stem Cell Behavior at Cell-Matrix Interface

    Zhang, Y., Gordon, A., Qian, W. & Chen, W., Sep 1 2015, In : Advanced healthcare materials. 4, 13, p. 1900-1914 15 p.

    Research output: Contribution to journalArticle

    Stem Cell Niche
    Stem cells
    Stem Cells
    Cues
    Regenerative Medicine

    Energy-Mediated Machinery Drives Cellular Mechanical Allostasis

    Wang, Q., Qian, W., Xu, X., Bajpai, A., Guan, K., Zhang, Z., Chen, R., Flamini, V. & Chen, W., Jan 1 2019, In : Advanced Materials. 1900453.

    Research output: Contribution to journalArticle

    Machinery
    Mechanics
    Energy barriers
    Stabilization
    Aging of materials

    Emerging microfluidic tools for functional cellular immunophenotyping: A new potential paradigm for immune status characterization

    Chen, W., Huang, N. T., Li, X., Yu, Z. T. F., Kurabayashi, K. & Fu, J., 2013, In : Frontiers in Oncology. 3 APR, Article 00098.

    Research output: Contribution to journalArticle

    Immunophenotyping
    Microfluidics
    Information Science
    Immunologic Monitoring
    Allergy and Immunology

    Emerging microengineered tools for functional analysis and phenotyping of blood cells

    Li, X., Chen, W., Li, Z., Li, L., Gu, H. & Fu, J., Nov 1 2014, In : Trends in Biotechnology. 32, 11, p. 586-594 9 p.

    Research output: Contribution to journalArticle

    Functional analysis
    Blood Cells
    Blood
    Cells
    Assays

    Elastomeric microposts integrated into microfluidics for flow-mediated endothelial mechanotransduction analysis

    Lam, R. H. W., Sun, Y., Chen, W. & Fu, J., Apr 24 2012, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 12, 10, p. 1865-1873 9 p.

    Research output: Contribution to journalArticle

    Microfluidics
    Cellular Microenvironment
    Rigidity
    Endothelial cells
    Adhesives

    Development of a shock acceleration microswitch with enhanced-contact and low off-axis sensitivity

    Yang, Z. Q., Ding, G. F., Cai, H. G., Wang, H., Chen, W. & Zhao, X. L., 2009, TRANSDUCERS 2009 - 15th International Conference on Solid-State Sensors, Actuators and Microsystems. p. 1940-1943 4 p. 5285669

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Beer
    Hammers
    Point contacts
    Electroplating
    Modal analysis
    Slot antennas
    Antenna feeders
    Antennas
    Microfabrication
    Studios