Photo of Weiqiang Chen

Weiqiang Chen

Assistant Professor

20062019
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Research Output 2006 2019

2019

Biophysical Phenotyping and Modulation of ALDH+ Inflammatory Breast Cancer Stem-Like Cells

Chen, W., Allen, S. G., Qian, W., Peng, Z., Han, S., Li, X., Sun, Y., Fournier, C., Bao, L., Lam, R. H. W., Merajver, S. D. & Fu, J., Jan 1 2019, (Accepted/In press) In : Small. 1802891.

Research output: Contribution to journalArticle

Inflammatory Breast Neoplasms
Neoplastic Stem Cells
Modulation
Bond strength (materials)
Formability

Cellogram: On-the-Fly Traction Force Microscopy

Lendenmann, T., Schneider, T., Dumas, J., Tarini, M., Giampietro, C., Bajpai, A., Chen, W., Gerber, J., Poulikakos, D., Ferrari, A. & Panozzo, D., Oct 9 2019, In : Nano Letters. 19, 10, p. 6742-6750 9 p.

Research output: Contribution to journalArticle

traction
Microscopic examination
microscopy
Image processing
Cells

Energy-Mediated Machinery Drives Cellular Mechanical Allostasis

Wang, Q., Qian, W., Xu, X., Bajpai, A., Guan, K., Zhang, Z., Chen, R., Flamini, V. & Chen, W., Jan 1 2019, In : Advanced Materials. 1900453.

Research output: Contribution to journalArticle

Machinery
Mechanics
Energy barriers
Stabilization
Aging of materials

Magnet Patterned Superparamagnetic Fe3O4/Au Core–Shell Nanoplasmonic Sensing Array for Label-Free High Throughput Cytokine Immunoassay

Cai, Y., Zhu, J., He, J., Yang, W., Ma, C., Xiong, F., Li, F., Chen, W. & Chen, P., Jan 1 2019, (Accepted/In press) In : Advanced healthcare materials. 1801478.

Research output: Contribution to journalArticle

Magnets
Microarrays
Immunoassay
Labels
Immunologic Monitoring

Probing Single-Cell Mechanical Allostasis Using Ultrasound Tweezers

Qian, W. & Chen, W., Jan 1 2019, In : Cellular and Molecular Bioengineering.

Research output: Contribution to journalArticle

Allostasis
Actomyosin
Ultrasound
Ultrasonics
Medical problems

Special Issue: Bio-Interfaces for Immunoengineering

Chen, W. & Kim, D. H., Feb 21 2019, In : Advanced Healthcare Materials. 8, 4, 1900098.

Research output: Contribution to journalEditorial

The Interplay Between Cell-Cell and Cell-Matrix Forces Regulates Cell Migration Dynamics

Bajpai, A., Tong, J., Qian, W., Peng, Y. & Chen, W., Nov 19 2019, In : Biophysical Journal. 117, 10, p. 1795-1804 10 p.

Research output: Contribution to journalArticle

Cell Movement
Traction
Extracellular Matrix
Wound Healing
Embryonic Development
2018

A fluorescent microbead-based microfluidic immunoassay chip for immune cell cytokine secretion quantification

Cui, X., Liu, Y., Hu, D., Qian, W., Tin, C., Sun, D., Chen, W. & Lam, R. H. W., Jan 1 2018, In : Lab on a Chip. 18, 3, p. 522-531 10 p.

Research output: Contribution to journalArticle

Microfluidics
Microspheres
Immunoassay
Cytokines
Lab-On-A-Chip Devices

An integrated adipose-tissue-on-chip nanoplasmonic biosensing platform for investigating obesity-associated inflammation

Zhu, J., He, J., Verano, M., Brimmo, A. T., Glia, A., Qasaimeh, M., Chen, P., Aleman, J. O. & Chen, W., Dec 7 2018, In : Lab on a Chip. 18, 23, p. 3550-3560 11 p.

Research output: Contribution to journalArticle

Adipose Tissue
Obesity
Tissue
Cytokines
Inflammation

A Photoresponsive Hyaluronan Hydrogel Nanocomposite for Dynamic Macrophage Immunomodulation

Wang, H., Morales, R. T. T., Cui, X., Huang, J., Qian, W., Tong, J. & Chen, W., Jan 1 2018, (Accepted/In press) In : Advanced healthcare materials. 1801234.

Research output: Contribution to journalArticle

Nanocomposites
Immunomodulation
Macrophages
Hydrogel
Hyaluronic Acid

Deconstructing Immune Microenvironments of Lymphoid Tissues for Reverse Engineering

Gunn, I-I., Nasser, R., Garcia-Sabaté, A., Sapudom, J., Ma, C., Chen, W. & Teo, J., Jan 1 2018, (Accepted/In press) In : Advanced healthcare materials. 1801126.

Research output: Contribution to journalReview article

Aptitude
Reverse engineering
Immune system
Lymphoid Tissue
Surface topography

Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis

Cui, X., Morales, R. T. T., Qian, W., Wang, H., Gagner, J. P., Dolgalev, I., Placantonakis, D., Zagzag, D., Cimmino, L., Snuderl, M., Lam, R. H. W. & Chen, W., Apr 1 2018, In : Biomaterials. 161, p. 164-178 15 p.

Research output: Contribution to journalArticle

Macrophages
Glioblastoma
Immunosuppression
Tumors
Immunosuppressive Agents

Nanotopography regulates motor neuron differentiation of human pluripotent stem cells

Chen, W., Han, S., Qian, W., Weng, S., Yang, H., Sun, Y., Villa-Diaz, L. G., Krebsbach, P. H. & Fu, J., Feb 21 2018, In : Nanoscale. 10, 7, p. 3556-3565 10 p.

Research output: Contribution to journalArticle

Stem cells
Neurons
Actomyosin
Cell adhesion
Reactive ion etching
2017

Nanotopographic Regulation of Human Mesenchymal Stem Cell Osteogenesis

Qian, W., Gong, L., Cui, X., Zhang, Z., Bajpai, A., Liu, C., Castillo, A., Teo, J. & Chen, W., Dec 6 2017, In : ACS Applied Materials and Interfaces. 9, 48, p. 41794-41806 13 p.

Research output: Contribution to journalArticle

Stem cells
Dexamethasone
Modulators
Bone
Adhesion
2016

Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis

Weng, S., Shao, Y., Chen, W. & Fu, J., May 30 2016, (Accepted/In press) In : Nature Materials.

Research output: Contribution to journalArticle

homeostasis
adhesion
Adhesion
cells
Integrins

Multiparametric Biomechanical and Biochemical Phenotypic Profiling of Single Cancer Cells Using an Elasticity Microcytometer

Hu, S., Liu, G., Chen, W., Li, X., Lu, W., Lam, R. H. W. & Fu, J., 2016, (Accepted/In press) In : Small.

Research output: Contribution to journalArticle

Elasticity
Cells
Neoplasms
Formability
Microfluidics

Nanoroughened adhesion-based capture of circulating tumor cells with heterogeneous expression and metastatic characteristics

Chen, W., Allen, S. G., Reka, A. K., Qian, W., Han, S., Zhao, J., Bao, L., Keshamouni, V. G., Merajver, S. D. & Fu, J., Aug 8 2016, In : BMC Cancer. 16, 1, 614.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Microfluidics
Glass
Neoplasms
Lung Neoplasms

Osteoblast-derived paracrine factors regulate angiogenesis in response to mechanical stimulation

Liu, C., Cui, X., Ackermann, T. M., Flamini, V., Chen, W. & Castillo, A., Jul 1 2016, In : Integrative Biology (United Kingdom). 8, 7, p. 785-794 10 p.

Research output: Contribution to journalArticle

Angiogenesis Inducing Agents
Osteoblasts
Endothelial cells
Conditioned Culture Medium
Endothelial Cells

Surface micromachining of polydimethylsiloxane for microfluidics applications

Hill, S., Qian, W., Chen, W. & Fu, J., Sep 1 2016, In : Biomicrofluidics. 10, 5, 054114.

Research output: Contribution to journalArticle

Microtechnology
Surface micromachining
Microfluidics
Polydimethylsiloxane
micromachining
2015

Capturing Cancer: Emerging Microfluidic Technologies for the Capture and Characterization of Circulating Tumor Cells

Qian, W., Zhang, Y. & Chen, W., Aug 1 2015, In : Small. 11, 32, p. 3850-3872 23 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Microfluidics
Tumors
Cells
Technology

Engineering Nanoscale Stem Cell Niche: Direct Stem Cell Behavior at Cell-Matrix Interface

Zhang, Y., Gordon, A., Qian, W. & Chen, W., Sep 1 2015, In : Advanced healthcare materials. 4, 13, p. 1900-1914 15 p.

Research output: Contribution to journalArticle

Stem Cell Niche
Stem cells
Stem Cells
Cues
Regenerative Medicine

Nanotopographic Biomaterials for Isolation of Circulating Tumor Cells

Qian, W., Zhang, Y., Gordon, A. & Chen, W., Nov 1 2015, In : Journal of Nanotechnology in Engineering and Medicine. 5, 4, 040802.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Biocompatible Materials
Biomaterials
Tumors
Cells
2014

Continuous-flow microfluidic blood cell sorting for unprocessed whole blood using surface-micromachined microfiltration membranes

Li, X., Chen, W., Liu, G., Lu, W. & Fu, J., 2014, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, p. 1151-1153 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Microfiltration
Sorting
Microfluidics
Blood
Cells

Continuous-flow microfluidic blood cell sorting for unprocessed whole blood using surface-micromachined microfiltration membranes

Li, X., Chen, W., Liu, G., Lu, W. & Fu, J., Jul 21 2014, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 14, 14, p. 2565-2575 11 p.

Research output: Contribution to journalArticle

Microfiltration
Microfluidics
Sorting
Blood Cells
Blood

Emerging microengineered tools for functional analysis and phenotyping of blood cells

Li, X., Chen, W., Li, Z., Li, L., Gu, H. & Fu, J., Nov 1 2014, In : Trends in Biotechnology. 32, 11, p. 586-594 9 p.

Research output: Contribution to journalArticle

Functional analysis
Blood Cells
Blood
Cells
Assays

Global architecture of the F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction

Shao, Y., Mann, J. M., Chen, W. & Fu, J., Mar 2014, In : Integrative Biology (United Kingdom). 6, 3, p. 300-311 12 p.

Research output: Contribution to journalArticle

Cell Shape
Endothelial cells
Actin Cytoskeleton
Actins
Endothelial Cells

Hippo/YAP-mediated rigidity-dependent motor neuron differentiation of human pluripotent stem cells

Sun, Y., Yong, K. M. A., Villa-Diaz, L. G., Zhang, X., Chen, W., Philson, R., Weng, S., Xu, H., Krebsbach, P. H. & Fu, J., 2014, In : Nature Materials. 13, 6, p. 599-604 6 p.

Research output: Contribution to journalArticle

stem cells
Stem cells
neurons
rigidity
Rigidity

Integrated nanoplasmonic sensing for cellular functional immunoanalysis using human blood

Oh, B. R., Huang, N. T., Chen, W., Seo, J. H., Chen, P., Cornell, T. T., Shanley, T. P., Fu, J. & Kurabayashi, K., Mar 25 2014, In : ACS Nano. 8, 3, p. 2667-2676 10 p.

Research output: Contribution to journalArticle

Surface plasmon resonance
blood
Assays
Blood
surface plasmon resonance

Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the bottom

Chen, W., Shao, Y., Li, X., Zhao, G. & Fu, J., Dec 1 2014, In : Nano Today. 9, 6, p. 759-784 26 p.

Research output: Contribution to journalArticle

Biophysics
Stem cells
Stem Cells
Embryonic Development
Cellular Mechanotransduction
2013

Acoustic tweezing cytometry for live-cell subcellular modulation of intracellular cytoskeleton contractility

Fan, Z., Sun, Y., Di Chen, C., Tay, D., Chen, W., Deng, C. X. & Fu, J., 2013, In : Scientific Reports. 3, 2176.

Research output: Contribution to journalArticle

Cytoskeleton
Acoustics
Microbubbles
Actin Cytoskeleton
Ultrasonics

Adhesion strength-based, label-free isolation of human pluripotent stem cells

Singh, A., Suri, S., Lee, T., Chilton, J. M., Cooke, M. T., Chen, W., Fu, J., Stice, S. L., Lu, H., McDevitt, T. C. & García, A. J., May 2013, In : Nature Methods. 10, 5, p. 438-444 7 p.

Research output: Contribution to journalArticle

Pluripotent Stem Cells
Bond strength (materials)
Stem cells
Labels
Microfluidics

Capture circulating tumor cells on glass

Chen, W., Weng, S., Allen, S., Merajver, S. D. & Fu, J., 2013, The 2013 University of Michigan Annual Symposium of the Microfluidics in Biomedical Sciences Training Program, Ann Arbor, MI, May 2013.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Emerging microfluidic tools for functional cellular immunophenotyping: A new potential paradigm for immune status characterization

Chen, W., Huang, N. T., Li, X., Yu, Z. T. F., Kurabayashi, K. & Fu, J., 2013, In : Frontiers in Oncology. 3 APR, Article 00098.

Research output: Contribution to journalArticle

Immunophenotyping
Microfluidics
Information Science
Immunologic Monitoring
Allergy and Immunology

Integrated microfluidic platform for efficient isolation and functional immunophenotyping of subpopulations of immune cells

Chen, W., Huang, N., Oh, B., Kurabayashi, K. & Fu, J., 2013, Proceedings of the ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology (NEMB 2013), Boston, MA, February 2013.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Localized surface plasmon resonance (LSPR) optofluidic biosensor for label-free cellular immunophenotyping

Oh, B. R., Huang, N. T., Chen, W., Seo, J., Fu, J. & Kurabayashi, K., 2013, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society, Vol. 1. p. 92-94 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Surface plasmon resonance
Biosensors
Labels
Cytokines
Microfluidics

Microfabricated nanotopological surfaces for study of adhesion-dependent cell mechanosensitivity

Chen, W., Sun, Y. & Fu, J., Jan 14 2013, In : Small. 9, 1, p. 81-89 9 p.

Research output: Contribution to journalArticle

Cell Adhesion
Adhesion
Glass
Microtechnology
Cellular Microenvironment

Microfluidic immunophenotyping assay platform for immunomonitoring of subpopulations of immune cells

Chen, W., Huang, N., Oh, B., Cornell, T. T., Shanley, T. P., Kurabayashi, K. & Fu, J., 2013, 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013. Chemical and Biological Microsystems Society, Vol. 3. p. 1761-1763 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Microfluidics
Assays
Immune system
Blood

Nanoroughened surfaces for efficient capture of circulating tumor cells without using capture antibodies

Chen, W., Weng, S., Zhang, F., Allen, S., Li, X., Bao, L., Lam, R. H. W., MacOska, J. A., Merajver, S. D. & Fu, J., Jan 22 2013, In : ACS Nano. 7, 1, p. 566-575 10 p.

Research output: Contribution to journalArticle

antibodies
Antibodies
Tumors
tumors
Cells

Nanotopographic surface for efficient capture of circulating tumor cells

Chen, W., Weng, S. & Fu, J., 2013, Proceedings of the ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology (NEMB 2013), Boston, MA, February 2013.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Surface-Micromachined Microfiltration Membranes for Efficient Isolation and Functional Immunophenotyping of Subpopulations of Immune Cells

Chen, W., Huang, N. T., Oh, B., Lam, R. H. W., Fan, R., Cornell, T. T., Shanley, T. P., Kurabayashi, K. & Fu, J., Jul 2013, In : Advanced healthcare materials. 2, 7, p. 965-975 11 p.

Research output: Contribution to journalArticle

Immunophenotyping
Microfiltration
Membranes
Cellular Immunity
Blood Cells
2012

An integrated microfluidic platform for in-situ cellular cytokine secretion immunophenotyping

Huang, N. T., Chen, W., Oh, B. R., Fu, J. & Kurabayashi, K., 2012, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, p. 989-991 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Microfluidics
Assays
Cytokines
Immunosorbents
Chemiluminescence

An integrated microfluidic platform for in-situ cellular cytokine secretion immunophenotyping

Huang, N-T., Chen, W., Oh, B-R., Cornell, T. T., Shanley, T. P., Fu, J. & Kurabayashi, K., 2012, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 12, 20, p. 4093-4101

Research output: Contribution to journalArticle

Elastomeric microposts integrated into microfluidics for flow-mediated endothelial mechanotransduction analysis

Lam, R. H. W., Sun, Y., Chen, W. & Fu, J., Apr 24 2012, In : Lab on a Chip - Miniaturisation for Chemistry and Biology. 12, 10, p. 1865-1873 9 p.

Research output: Contribution to journalArticle

Microfluidics
Cellular Microenvironment
Rigidity
Endothelial cells
Adhesives

In silico experimentation of glioma microenvironment development and anti-tumor therapy

Wu, Y., Lu, Y., Chen, W., Fu, J. & Fan, R., Feb 2012, In : PLoS Computational Biology. 8, 2, e1002355.

Research output: Contribution to journalArticle

tumor
Glioma
Computer Simulation
Experimentation
Therapy

Integrated microfluidic chip for efficient isolation and functional immunophenotyping of subpopulations of immune cells

Chen, W., Huang, N., Oh, B., Cornell, T. T., Shanley, T. P., Kurabayashi, K. & Fu, J., 2012, The 2012 University of Michigan Engineering Graduate Sympousium, Ann Arbor, MI, November 2012.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Investigation of mechanoresponsive behaviors of human embryonic stem cells using microfabricated elastomeric post arrays

Sun, Y., Villa-Diaz, L. G., Lam, R. H. W., Chen, W., Krebsbach, P. H. & Fu, J., 2012, ASME 2012 Summer Bioengineering Conference, SBC 2012. p. 317-318 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Stem cells

Mechanics regulates fate decisions of human embryonic stem cells

Sun, Y., Villa-Diaz, L. G., Lam, R. H. W., Chen, W., Krebsbach, P. H. & Fu, J., May 16 2012, In : PLoS One. 7, 5, e37178.

Research output: Contribution to journalArticle

embryonic stem cells
Stem cells
Mechanics
mechanics
cytoskeleton

Micromechanical elastomeric devices for investigations of mechanobiology in human embryonic stem cells

Sun, Y., Villa-Diaz, L. G., Lam, R. H. W., Chen, W., Krebsbach, P. H. & Fu, J., 2012, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, p. 1714-1716 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Stem cells
elastomeric
Cadherins
Rigidity
Mechanics

Nanotopography-based circular tumor cell capture

Chen, W., Weng, S. & Fu, J., 2012, The 4th Annual Michigan Graduate Academic Conference, East Lansing, MI, May 2012.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nanotopography directs fate of human embryonic stem cells

Chen, W., Villa-Diaz, L. G., Sun, Y., Weng, S., Kim, J. K., Krebsbach, P. H. & Fu, J., 2012, ASME 2012 Summer Bioengineering Conference, SBC 2012. p. 1293-1294 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Stem cells