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Timothy Dore

Associate Professor of Chemistry

    19962019
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    Research Output 1996 2019

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    Article
    2019

    Photorearrangement of Quinoline-Protected Dialkylanilines and the Photorelease of Aniline-Containing Biological Effectors

    Deodato, D., Asad, N. & Dore, T., Jun 7 2019, In : Journal of Organic Chemistry. 84, 11, p. 7342-7353 12 p.

    Research output: Contribution to journalArticle

    Mifepristone
    Mammals
    Gene expression
    Genes
    Switches
    2018

    Bypassing Glutamic Acid Decarboxylase 1 (Gad1) Induced Craniofacial Defects with a Photoactivatable Translation Blocker Morpholino

    Beebe, L. L., Deodato, D., Ball, R. E., Page, A. T., Vanleuven, A. J., Harris, K. T., Park, S., Hariharan, V., Lauderdale, J. D., Dore, T. & O'Connor, M., Jan 1 2018, (Accepted/In press) In : ACS Chemical Neuroscience.

    Research output: Contribution to journalArticle

    Morpholinos
    Glutamate Decarboxylase
    Defects
    Zebrafish
    Genes
    2017

    A spectroscopic study of the excited state proton transfer processes of (8-bromo-7-hydroxyquinolin-2-yl)methyl-protected phenol in aqueous solutions

    Huang, J., Muliawan, A. P., Ma, J., Li, M. D., Chiu, H. K., Lan, X., Deodato, D., Phillips, D. L. & Dore, T., Jan 1 2017, In : Photochemical and Photobiological Sciences. 16, 4, p. 575-584 10 p.

    Research output: Contribution to journalArticle

    Proton transfer
    Phenol
    Excited states
    phenols
    acetonitrile

    Photochemical Activation of Tertiary Amines for Applications in Studying Cell Physiology

    Asad, N., Deodato, D., Lan, X., Widegren, M. B., Phillips, D. L., Du, L. & Dore, T., Jan 1 2017, In : Journal of the American Chemical Society. 139, 36, p. 12591-12600 10 p.

    Research output: Contribution to journalArticle

    Cell Physiological Phenomena
    Physiology
    Amines
    Chemical activation
    Photons

    Targeting type 2 diabetes with c-glucosyl dihydrochalcones as selective sodium glucose co-transporter 2 (sglt2) inhibitors: Synthesis and biological evaluation

    Jesus, A. R., Vila-Viçosa, D., Machuqueiro, M., Marques, A. P., Dore, T. & Rauter, A. P., Jan 26 2017, In : Journal of Medicinal Chemistry. 60, 2, p. 568-579 12 p.

    Research output: Contribution to journalArticle

    Sodium-Glucose Transporter 2
    Symporters
    Sodium-Glucose Transport Proteins
    Type 2 Diabetes Mellitus
    Inhibitory Concentration 50

    Unravelling the early photochemical behavior of (8-substituted-7-hydroxyquinolinyl)methyl acetates through electronic structure theory and ultrafast transient absorption spectroscopy

    Ma, J., Mewes, J. M., Harris, K. T., Dore, T., Phillips, D. L. & Dreuw, A., Jan 1 2017, In : Physical Chemistry Chemical Physics. 19, 2, p. 1089-1096 8 p.

    Research output: Contribution to journalArticle

    Absorption spectroscopy
    Excited states
    Electronic structure
    acetates
    absorption spectroscopy
    2016

    8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells

    Mohammed, I., Hampton, S. E., Ashall, L., Hildebrandt, E. R., Kutlik, R. A., Manandhar, S. P., Floyd, B. J., Smith, H. E., Dozier, J. K., Distefano, M. D., Schmidt, W. K. & Dore, T., Jan 15 2016, In : Bioorganic and Medicinal Chemistry. 24, 2, p. 160-178 19 p.

    Research output: Contribution to journalArticle

    Oxyquinoline
    Peptide Hydrolases
    Cells
    Membranes
    Enzymes
    2015

    Photoactivatable, biologically-relevant phenols with sensitivity toward 2-photon excitation

    McLain, D. E., Rea, A. C., Widegren, M. B. & Dore, T., Jan 1 2015, In : Photochemical and Photobiological Sciences. 14, 12, p. 2151-2158 8 p.

    Research output: Contribution to journalArticle

    Phenols
    phenols
    Estradiol
    Photons
    quantum efficiency
    2014

    Left-right patterning in Xenopus conjoined twin embryos requires serotonin signaling and gap junctions

    Vandenberg, L. N., Blackiston, D. J., Rea, A. C., Dore, T. & Levin, M., Jul 8 2014, In : International Journal of Developmental Biology. 58, 10-12, p. 799-809 11 p.

    Research output: Contribution to journalArticle

    Conjoined Twins
    Gap Junctions
    Xenopus
    Serotonin
    Embryonic Structures
    2013

    Light-activated serotonin for exploring its action in biological systems

    Rea, A. C., Vandenberg, L. N., Ball, R. E., Snouffer, A. A., Hudson, A. G., Zhu, Y., McLain, D. E., Johnston, L. L., Lauderdale, J. D., Levin, M. & Dore, T., Dec 19 2013, In : Chemistry and Biology. 20, 12, p. 1536-1546 11 p.

    Research output: Contribution to journalArticle

    Biological systems
    Serotonin
    Light
    Photons
    Physiological Phenomena
    2012

    Photochemical Modulation of Ras-Mediated Signal Transduction Using Caged Farnesyltransferase Inhibitors: Activation by One- and Two-Photon Excitation

    Abate-Pella, D., Zeliadt, N. A., Ochocki, J. D., Warmka, J. K., Dore, T., Blank, D. A., Wattenberg, E. V. & Distefano, M. D., May 7 2012, In : ChemBioChem. 13, 7, p. 1009-1016 8 p.

    Research output: Contribution to journalArticle

    Farnesyltranstransferase
    Prenylation
    Photochemistry
    ras Proteins
    Signal transduction

    Unraveling the mechanism of the photodeprotection reaction of 8-bromo- and 8-chloro-7-hydroxyquinoline caged acetates

    Ma, J., Rea, A. C., An, H., Ma, C., Guan, X., Li, M. D., Su, T., Yeung, C. S., Harris, K. T., Zhu, Y., Nganga, J. L., Fedoryak, O. D., Dore, T. & Phillips, D. L., May 29 2012, In : Chemistry - A European Journal. 18, 22, p. 6854-6865 12 p.

    Research output: Contribution to journalArticle

    Acetates
    Quantum efficiency
    Excited states
    Photons
    Dehalogenation
    2011

    Comparison of the absorption, emission, and resonance Raman spectra of 7-hydroxyquinoline and 8-bromo-7-hydroxyquinoline caged acetate

    Ma, J., Cheng, S. C., An, H., Li, M. D., Ma, C., Rea, A. C., Zhu, Y., Nganga, J. L., Dore, T. & Phillips, D. L., Oct 27 2011, In : Journal of Physical Chemistry A. 115, 42, p. 11632-11640 9 p.

    Research output: Contribution to journalArticle

    Raman scattering
    acetates
    Acetates
    Raman spectra
    aqueous solutions

    The Ras Converting Enzyme (Rce1p). Orthologs, Enzymology, and Inhibitors.

    Schmidt, W. K. & Dore, T., Nov 21 2011, In : Enzymes. 30, p. 231-258 28 p.

    Research output: Contribution to journalArticle

    Prenylation
    Endopeptidases
    Monomeric GTP-Binding Proteins
    Substrates
    Enzymes
    2010

    Modulation of the inhibitor properties of dipeptidyl (acyloxy)methyl ketones toward the CaaX proteases

    Dechert, A. M. R., MacNamara, J. P., Breevoort, S. R., Hildebrandt, E. R., Hembree, N. W., Rea, A. C., McLain, D. E., Porter, S. B., Schmidt, W. K. & Dore, T., Sep 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 17, p. 6230-6237 8 p.

    Research output: Contribution to journalArticle

    Ketones
    Peptide Hydrolases
    Modulation
    Cysteine Proteases
    Proteolysis

    Resonance Raman characterization of the different forms of ground-state 8-substituted 7-hydroxyquinoline caged acetate compounds in aqueous solutions

    An, H. Y., Ma, C., Li, W., Harris, K. T., Dore, T. & Phillips, D. L., Feb 25 2010, In : Journal of Physical Chemistry A. 114, 7, p. 2498-2505 8 p.

    Research output: Contribution to journalArticle

    Ground state
    acetates
    Acetates
    aqueous solutions
    ground state

    Sensitized two-photon photochemical deprotection

    Pirrung, M. C., Dore, T., Zhu, Y. & Rana, V. S., Jul 23 2010, In : Chemical Communications. 46, 29, p. 5313-5315 3 p.

    Research output: Contribution to journalArticle

    Photons
    Photochemical reactions
    2009

    Resonance raman characterization of different forms of ground-state 8-bromo-7-hydroxyquinoline caged acetate in aqueous solutions

    An, H. Y., Chensheng, M., Nganga, J. L., Zhu, Y., Dore, T. & Phillips, D. L., Mar 26 2009, In : Journal of Physical Chemistry A. 113, 12, p. 2831-2837 7 p.

    Research output: Contribution to journalArticle

    Ground state
    acetates
    Acetates
    aqueous solutions
    ground state

    Substituent effects on the sensitivity of a quinoline photoremovable protecting group to one- And two-photon excitation

    Jarrett Davis, M., Kragor, C. H., Reddie, K. G., Wilson, H. C., Zhu, Y. & Dore, T., Feb 20 2009, In : Journal of Organic Chemistry. 74, 4, p. 1721-1729 9 p.

    Research output: Contribution to journalArticle

    Chromophores
    Photons
    Functional groups
    Bromine
    quinoline
    2007

    Inhibition of the CaaX proteases Rce1p and Ste24p by peptidyl (acyloxy)methyl ketones

    Porter, S. B., Hildebrandt, E. R., Breevoort, S. R., Mokry, D. Z., Dore, T. & Schmidt, W. K., Jun 1 2007, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 6, p. 853-862 10 p.

    Research output: Contribution to journalArticle

    Ketones
    Peptide Hydrolases
    Tosylphenylalanyl Chloromethyl Ketone
    Enzymes
    Metalloproteases
    2006

    8-Bromo-7-hydroxyquinoline as a photoremovable protecting group for physiological use: Mechanism and scope

    Zhu, Y., Pavlos, C. M., Toscano, J. P. & Dore, T., Apr 5 2006, In : Journal of the American Chemical Society. 128, 13, p. 4267-4276 10 p.

    Research output: Contribution to journalArticle

    Tissue
    Infrared radiation
    Tissue culture
    Nucleic acids
    Physiology

    Inhibition of kinesin motor proteins by adociasulfate-2

    Reddie, K. G., Roberts, D. R. & Dore, T., Aug 10 2006, In : Journal of Medicinal Chemistry. 49, 16, p. 4857-4860 4 p.

    Research output: Contribution to journalArticle

    Kinesin
    Biological Products
    Proteins
    Cell Physiological Phenomena
    Transport Vesicles
    2005

    Light-mediated inhibition of protein synthesis

    Goard, M., Aakalu, G., Fedoryak, O. D., Quinonez, C., St. Julien, J., Poteet, S. J., Schuman, E. M. & Dore, T., Jan 1 2005, In : Chemistry and Biology. 12, 6, p. 685-693 9 p.

    Research output: Contribution to journalArticle

    Anisomycin
    Light
    Proteins
    7-hydroxycoumarin
    Biological Phenomena
    2004

    Bhc-cNMPs as either water-soluble or membrane-permeant photoreleasable cyclic nucleotides for both one- and two-photon excitation

    Furuta, T., Takeuchi, H., Isozaki, M., Takahashi, Y., Kanehara, M., Sugimoto, M., Watanabe, T., Noguchi, K., Dore, T., Kurahashi, T., Iwamura, M. & Tsien, R. Y., Aug 6 2004, In : ChemBioChem. 5, 8, p. 1119-1128 10 p.

    Research output: Contribution to journalArticle

    Cyclic Nucleotides
    Photons
    Nucleosides
    Membranes
    Water

    Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators

    Dooley, C. T., Dore, T., Hanson, G. T., Jackson, W. C., Remington, S. J. & Tsien, R. Y., May 21 2004, In : Journal of Biological Chemistry. 279, 21, p. 22284-22293 10 p.

    Research output: Contribution to journalArticle

    Green Fluorescent Proteins
    Oxidation-Reduction
    Cells
    Imaging techniques
    Glutathione Disulfide
    2003

    Bhc-diol as a photolabile protecting group for aldehydes and ketones

    Lu, M., Fedoryak, O. D., Moister, B. R. & Dore, T., Jun 12 2003, In : Organic Letters. 5, 12, p. 2119-2122 4 p.

    Research output: Contribution to journalArticle

    7-hydroxycoumarin
    Ketones
    aldehydes
    Photons
    Aldehydes
    2002

    Brominated hydroxyquinoline as a photolabile protecting group with sensitivity to multiphoton excitation

    Fedoryak, O. D. & Dore, T., Oct 3 2002, In : Organic Letters. 4, 20, p. 3419-3422 4 p.

    Research output: Contribution to journalArticle

    7-hydroxycoumarin
    Hydroxyquinolines
    Photochemistry
    Photolysis
    Photochemical reactions
    1999

    Brominated 7-hydroxycoumarin-4-ylmethyls: Photolabile protecting groups with biologically useful cross-sections for two photon photolysis

    Furuta, T., Wang, S. S. H., Dantzker, J. L., Dore, T., Bybee, W. J., Callaway, E. M., Denk, W. & Tsien, R. Y., Feb 16 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 4, p. 1193-1200 8 p.

    Research output: Contribution to journalArticle

    7-hydroxycoumarin
    Photolysis
    Photons
    Glutamic Acid
    Glutamates
    1998

    A formal synthesis of crinipellin B based on the arene-alkene meta- photocycloaddition reaction

    Wender, P. A. & Dore, T., Nov 19 1998, In : Tetrahedron Letters. 39, 47, p. 8589-8592 4 p.

    Research output: Contribution to journalArticle

    Alkenes
    2-toluic acid
    crinipellin
    1996

    An arene-alkene photocycloaddition-radical cyclization cascade: The first synthesis of cis,cis,cis,trans-[5.5.5.5]-fenestranes

    Wender, P. A., Dore, T. & DeLong, M. A., Oct 21 1996, In : Tetrahedron Letters. 37, 43, p. 7687-7690 4 p.

    Research output: Contribution to journalArticle

    Cyclization
    Alkenes
    lead tetraacetate